Patent US5217427A successfully refreshed from Google Patents.
US5217427A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Centrifuge assembly
Assignee: Baxter International Inc
•
Filing: 1991-10-04
•
Granted: 1993-06-08
•
Expires: 2011-10-04
Abstract
Abstract A blood component separating device comprises a centrifuge bowl adapted for rotation about its axis in a centrifuge. The bowl defines an outer arcuate wall plus an inner circumferential wall, spaced from the outer wall, to define a arcuate slot adapted for receiving blood components. Access tubing is adapted for communication with the slot. Preferably, an elongated, flexible, collapsible inner liner is provided in the slot. Individual access tubing also may communicate with an elongated container interior between the ends of the elongated, collapsible container. Furthermore, a portion of the slot may define the shape of an outwardly extending spiral, to provide an increasing gravitational field upon fluids therein as the fluid moves along the slot.
Inventors
- 👤 Herbert M. Cullis
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 19:10
CPC Classifications
C; C07; C07K; C07K16/00; C07K16/06; B; B04; B04B; B04B1/00; B04B5/00; B04B5/04; B04B5/0407; B04B5/0428; B04B5/0442; C07K16/18; C07K16/28; C07K16/30; F; F04; F04B; F04B43/00; F04B43/08; F04B43/10; F04B9/00; F04B9/02; B04B2005/045; B04B2005/0464
Claims Analysis
Total Claims: 56
Claim 1
Independent Claim
75 words
A centrifuge assembly comprising: rotor; means defining a generally annularly extending multi-portion processing channel in said rotor for processing a suspension including at least one cell component; said processing channel including one portion for performing a separation function and another portion for performing another separation function; said other portion of said channel being generally spiral-like relative to the true center of said rotor; and said processing channel having a total arc not greater than 360°.
Claim 2
Dependent Claim
75 words
A centrifuge assembly comprising: rotor; means defining a generally annularly extending multi-portion processing channel in said rotor for processing a suspension including at least one cell component; said processing channel including one portion for performing a separation function and another portion for performing another separation function; said other portion of said channel being generally spiral-like relative to the true center of said rotor; and said processing channel having a total arc not greater than 360°.
Claim 3
Dependent Claim
17 words
The centrifuge assembly of claim 1 wherein said one portion of said processing channel is generally arcuate.
Claim 4
Dependent Claim
17 words
The centrifuge assembly of claim 2 wherein said one portion of said processing channel is generally circular.
Claim 5
Dependent Claim
37 words
The centrifuge assembly of claim 1 wherein said processing channel is defined by a pair of spaced-apart rigid vertical walls, said channel having a height substantially greater than its width along a substantial length of said channel.
Claim 6
Dependent Claim
36 words
The centrifuge assembly of claim 1 wherein said channel includes radially inner and outer wall surfaces, and a suspension component receiving pocket is defined by said outer wall surface at a selected location in said channel.
Claim 7
Dependent Claim
20 words
The centrifuge assembly of claim 5 wherein said pocket is defined in said one of said portions of said channel.
Claim 8
Dependent Claim
77 words
The centrifuge assembly of claim 1 wherein said channel includes radially inner and outer wall surfaces, said outer wall surface of said channel including a transition portion of decreasing radius relative to said true center of said rotor, said transition portion being located between said one and said other portions of said channel and defining a generally inwardly extending surface within said channel to restrict the flow of a suspension component between said one and other portions.
Claim 9
Dependent Claim
33 words
The centrifuge assembly of claim 1 wherein the suspension comprises blood, and said channel contains a quantity of blood which is relatively small compared to the volume of blood in a human donor.
Claim 10
Dependent Claim
157 words
A centrifuge assembly comprising: a rotor; means defining a generally annularly extending multi-portion processing channel in said rotor for processing a suspension including at least one cell component; said channel including one portion for performing a separation function and another portion for performing another separation function; said other portion of said channel being generally spiral-like relative to the true center of said rotor; and fluid connection means at separated locations of said channel for introducing the suspension into and for extracting at least one suspension component from said channel, said fluid connection means including: a first fluid connection means; (a) communicating with said other, spiral-like portion of said channel, (b) being adapted for extracting a suspension component from said other, spiral-like portion of said channel, and (c) being located at a greater radial distance from the true center of the rotor than the radial distance where the suspension component enters said other, spiral-like portion of said channel.
Claim 11
Dependent Claim
157 words
A centrifuge assembly comprising: a rotor; means defining a generally annularly extending multi-portion processing channel in said rotor for processing a suspension including at least one cell component; said channel including one portion for performing a separation function and another portion for performing another separation function; said other portion of said channel being generally spiral-like relative to the true center of said rotor; and fluid connection means at separated locations of said channel for introducing the suspension into and for extracting at least one suspension component from said channel, said fluid connection means including: a first fluid connection means; (a) communicating with said other, spiral-like portion of said channel, (b) being adapted for extracting a suspension component from said other, spiral-like portion of said channel, and (c) being located at a greater radial distance from the true center of the rotor than the radial distance where the suspension component enters said other, spiral-like portion of said channel.
Claim 12
Dependent Claim
82 words
The centrifuge assembly of claim 9 wherein said fluid connection means further comprises a second fluid connection means communicating with said channel at a location spaced from the true center of rotation of said rotor for introducing the suspension into said channel, a third fluid connection means communicating with said one portion of said channel for removing a second suspension component and a fourth fluid connection means communicating with said channel at a selected location for removing another portion of said suspension.
Claim 13
Dependent Claim
17 words
The centrifuge assembly of claim 9 wherein said one portion of said processing channel is generally arcuate.
Claim 14
Dependent Claim
33 words
The centrifuge assembly of claim 9 wherein said channel is defined by a pair of spaced-apart rigid vertical walls, a substantial part of said channel having a height substantially greater than its width.
Claim 15
Dependent Claim
36 words
The centrifuge assembly of claim 9 wherein said channel includes radially inner and outer wall surfaces, and a suspension component receiving pocket is defined by said outer wall surface at a selected location in said channel.
Claim 16
Dependent Claim
20 words
The centrifuge assembly of claim 13 wherein said pocket is defined in said one of said portions of said channel.
Claim 17
Dependent Claim
76 words
The centrifuge assembly of claim 9 wherein said channel includes radially inner and outer wall surfaces, said outer wall surface of said channel including a transition portion of decreasing radius relative to said true center of said rotor, said transition portion being located between said one and other portions of said channel and defining a generally inwardly extending surface within said channel to restrict the flow of a suspension component between said one and other portions.
Claim 18
Dependent Claim
33 words
The centrifuge assembly of claim 9 wherein the suspension comprises blood, and said channel contains a quantity of blood which is relatively small compared to the volume of blood in a human donor.
Claim 19
Dependent Claim
134 words
A centrifuge assembly comprising: a rotor; means providing a generally annularly extending multi-portion processing channel in said rotor for processing a suspension including at least one cell component; said channel including one portion for performing a separation function and another portion for performing another separation function; said other portion of said channel being generally spiral-like relative to the true center of said rotor; said multi-portion processing channel having a total arc not greater than 360°; fluid connection means at separated locations along said channel for introducing the suspension and for extracting at least one suspension component from said channel; one of said fluid connection means for extracting a suspension component (a) communicating with said other, spiral-like portion of the channel and (b) being adapted for extracting a suspension component from the other, spiral-like portion.
Claim 20
Dependent Claim
134 words
A centrifuge assembly comprising: a rotor; means providing a generally annularly extending multi-portion processing channel in said rotor for processing a suspension including at least one cell component; said channel including one portion for performing a separation function and another portion for performing another separation function; said other portion of said channel being generally spiral-like relative to the true center of said rotor; said multi-portion processing channel having a total arc not greater than 360°; fluid connection means at separated locations along said channel for introducing the suspension and for extracting at least one suspension component from said channel; one of said fluid connection means for extracting a suspension component (a) communicating with said other, spiral-like portion of the channel and (b) being adapted for extracting a suspension component from the other, spiral-like portion.
Claim 21
Dependent Claim
17 words
The centrifuge assembly of claim 17 wherein said one portion of said processing channel is generally arcuate.
Claim 22
Dependent Claim
17 words
The centrifuge assembly of claim 18 wherein said one portion of said processing channel is generally circular.
Claim 23
Dependent Claim
37 words
The centrifuge assembly of claim 17 wherein said processing channel is defined by a pair of spaced-apart rigid vertical walls, said channel having a height substantially greater than its width along a substantial length of said channel.
Claim 24
Dependent Claim
82 words
The centrifuge assembly of claim 17 wherein said fluid connection means further comprises a second fluid connection means communicating with said channel at a location spaced from the true center of rotation of said rotor for introducing the suspension into said channel, a third fluid connection means communicating with said one portion of said channel for removing a second suspension component and a fourth fluid connection means communicating with said channel at a selected location for removing another portion of said suspension.
Claim 25
Dependent Claim
40 words
The centrifuge assembly of claim 17 wherein said channel includes radially inner and outer wall surfaces, and said one of said fluid connection means communicates with a suspension component receiving pocket defined by said outer wall in said one portion.
Claim 26
Dependent Claim
41 words
The centrifuge assembly of claim 17 wherein said one fluid connection means is located at a greater radial distance from the true center of the rotor than the radial distance where said suspension component enters said spiral-like portion of said channel.
Claim 27
Dependent Claim
33 words
The centrifuge assembly of claim 17 wherein the suspension comprises blood, and said channel contains a quantity of blood which is relatively small compared to the volume of blood in a human donor.
Claim 28
Dependent Claim
124 words
A centrifuge assembly comprising: a rotor; a generally annularly extending multi-portion processing channel defined in said rotor for processing a suspension including at least one cell component, said processing channel being defined by a pair of spaced-apart rigid vertical walls, said channel having a height substantially greater than its width along a substantial length of said channel; said processing channel including, a first arcuate portion, a second portion which is generally spiral-like, and a transition portion of decreasing radius relative to said true center of said rotor, said transition portion being located between said first and second portions and defining a generally inwardly extending surface within said channel to restrict the passage of at least one suspension component between said first and second portions.
Claim 29
Dependent Claim
124 words
A centrifuge assembly comprising: a rotor; a generally annularly extending multi-portion processing channel defined in said rotor for processing a suspension including at least one cell component, said processing channel being defined by a pair of spaced-apart rigid vertical walls, said channel having a height substantially greater than its width along a substantial length of said channel; said processing channel including, a first arcuate portion, a second portion which is generally spiral-like, and a transition portion of decreasing radius relative to said true center of said rotor, said transition portion being located between said first and second portions and defining a generally inwardly extending surface within said channel to restrict the passage of at least one suspension component between said first and second portions.
Claim 30
Dependent Claim
21 words
The centrifuge assembly of claim 25 further comprising a suspension component receiving pocket defined in at least one of said portions.
Claim 31
Dependent Claim
17 words
The centrifuge assembly of claim 25 wherein said first portion of said processing channel is generally circular.
Claim 32
Dependent Claim
97 words
The centrifuge assembly of claim 25 further comprising fluid connection means at separated locations of said channel for introducing the suspension into and for extracting at least one suspension component from said channel, said fluid connection means including: a first fluid connection means; (a) communicating with said spiral-like portion of said channel, (b) being adapted for extracting a suspension component from said spiral-like portion of said channel, and (c) being located at a greater radial distance from the true center of the rotor than the radial distance the suspension component enters the spiral-like portion of said channel.
Claim 33
Dependent Claim
18 words
The centrifuge assembly of claim 25 wherein said processing channel has a total arc not greater than 360°.
Claim 34
Dependent Claim
33 words
The centrifuge assembly of claim 25 wherein the suspension comprises blood, and said channel contains a quantity of blood which is relatively small compared to the volume of blood in a human donor.
Claim 35
Dependent Claim
50 words
A centrifuge assembly comprising: a rotor; means providing a generally annularly extending multi-portion processing channel in said rotor for processing a suspension including at least one cell component; extracting a portion of said suspension from said channel at a third location which is spaced from said first and second locations.
Claim 36
Dependent Claim
50 words
A centrifuge assembly comprising: a rotor; means providing a generally annularly extending multi-portion processing channel in said rotor for processing a suspension including at least one cell component; extracting a portion of said suspension from said channel at a third location which is spaced from said first and second locations.
Claim 37
Dependent Claim
163 words
A process for separating a suspension component from a suspension containing a cell component comprising: providing a centrifuge assembly comprising a rotor having a generally annularly extending multi-portion processing channel defined therein, said channel having one portion for performing a separation function and another portion which is generally spiral-like relative to the true center of the rotor for performing another separation function; introducing said suspension into the processing channel at a first location and passing the suspension or component thereof through at least a part of said one and said other portions of said channel; rotating the centrifuge assembly to separate a first suspension component in the suspension; and extracting said first suspension component from said other, spiral-like portion of said channel at a second location that is at a greater radial distance from the true center of said rotor than the radial distance where said first suspension component enters said spiral-like portion of said channel and is spaced from said first location.
Claim 38
Dependent Claim
163 words
A process for separating a suspension component from a suspension containing a cell component comprising: providing a centrifuge assembly comprising a rotor having a generally annularly extending multi-portion processing channel defined therein, said channel having one portion for performing a separation function and another portion which is generally spiral-like relative to the true center of the rotor for performing another separation function; introducing said suspension into the processing channel at a first location and passing the suspension or component thereof through at least a part of said one and said other portions of said channel; rotating the centrifuge assembly to separate a first suspension component in the suspension; and extracting said first suspension component from said other, spiral-like portion of said channel at a second location that is at a greater radial distance from the true center of said rotor than the radial distance where said first suspension component enters said spiral-like portion of said channel and is spaced from said first location.
Claim 39
Dependent Claim
45 words
The process of claim 32 further including: restricting passage of a suspension component between said one and other portions of said channel; and extracting a portion of said suspension from said channel at a third location which is spaced from said first and second locations.
Claim 40
Dependent Claim
14 words
The process of claim 33 wherein said portion of said suspension substantially comprises plasma.
Claim 41
Dependent Claim
26 words
The process of claim 33 wherein said first suspension component includes a first cell component and said portion of said suspension comprises a second cell component.
Claim 42
Dependent Claim
50 words
The process of claim 33 wherein the step of introducing the suspension comprises introducing blood directly into said other, spiral-like portion; said restricted suspension component being said first suspension component and substantially comprising red blood cells; and said portion of said suspension extracted at said third location substantially comprising plasma.
Claim 43
Dependent Claim
59 words
The process of claim 33 wherein the suspension comprises blood, the first suspension component substantially comprises a first blood cell, the restricted suspension component substantially comprises red blood cells, said portion of said suspension extracted at said third location substantially comprises plasma, and said process includes extracting a second blood cell component from said one portion of said channel.
Claim 44
Dependent Claim
19 words
The process of claim 37 further comprising the step of concentrating platelets in a selected area of said channel.
Claim 45
Dependent Claim
16 words
The centrifuge assembly of claim 37 wherein said first blood cell substantially comprises red blood cells.
Claim 46
Dependent Claim
18 words
The process of claim 32 wherein the total arc of said processing channel is not greater than 360°.
Claim 47
Dependent Claim
20 words
The process of claim 32 further comprising collecting said first suspension component in a pocket defined in said one portion.
Claim 48
Dependent Claim
14 words
The process of claim 32 wherein said one portion of said channel is arcuate.
Claim 49
Dependent Claim
15 words
The process of claim 42 wherein said one portion of said channel is generally circular.
Claim 50
Dependent Claim
17 words
The process of claim 32 wherein said processing channel has a total arc of less than 180°.
Claim 51
Dependent Claim
20 words
The centrifuge assembly of claims 1, 9, 17, 25, or 31 wherein the suspension comprises at least one blood cell.
Claim 52
Dependent Claim
12 words
The centrifuge assembly of claim 45 wherein the suspension comprises whoel blood.
Claim 53
Dependent Claim
31 words
The centrifuge assembly of claim 5, 13, 25, 26 wherein the suspension comprises at least one blood cell, and said suspension receiving pocket is adapted to collect said one blood cell.
Claim 54
Dependent Claim
45 words
The centrifuge assembly of claim 13 or 26 wherein the suspension comprises at least one blood cell, said suspension receiving pocket is adapted to collect said one blood cell, further comprising fluid collection means communicating with said pocket for removal of said one blood cell.
Claim 55
Dependent Claim
37 words
The centrifuge assembly of claim 41, 12, 20 or 28 wherein the suspension comprises blood, and said channel contains a quantity of blood which is relatively small compared to the volume of blood in a human donor.
Claim 56
Dependent Claim
23 words
The centrifuge assembly of claims 1, 9, 17, 25, or 31 wherein said processing channel has a total arc of less than 180°.
References Cited (Backward Citations)
DE43693C
Cited
US3127342A
Cited
US1472085A
Cited
US1512469A
Cited
GB373493A
Cited
US1954676A
Cited
US2083899A
Cited
US2261394A
Cited
US2269716A
Cited
US2321144A
Cited
US2662687A
Cited
US2719668A
Cited
GB729169A
Cited
US2730299A
Cited
US2885145A
Cited
GB812115A
Cited
GB873494A
Cited
US3090549A
Cited
US3096282A
Cited
US2952258A
Cited
US3129175A
Cited
US3672564A
Cited
US3655123A
Cited
US3708110A
Cited
US3703984A
Cited
US3724747A
Cited
US3858796A
Cited
US3698626A
Cited
GB1336965A
Cited
US3737096A
Cited
US3748101A
Cited
US3862715A
Cited
US3724727A
Cited
GB1471204A
Cited
US3825175A
Cited
GB1451859A
Cited
US3987961A
Cited
US4113173A
Cited
US4056224A
Cited
US3955755A
Cited
US3957197A
Cited
GB1509667A
Cited
US4007871A
Cited
GB1511819A
Cited
US4010894A
Cited
US4425112A
Cited
US4734089A
Cited
US4086924A
Cited
US4069968A
Cited
US4091989A
Cited
US4430072A
Cited
US4120448A
Cited
US4109854A
Cited
US4094461A
Cited
US4419089A
Cited
US4356958A
Cited
US4230263A
Cited
US4387848A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-06-07 | 1996-12-07 | 1997-06-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-06-07 | 2000-12-07 | 2001-06-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-06-07 | 2004-12-07 | 2005-06-08 | $7700.00 | Window Closed / Lapsed |