US5217426A — Combination disposable plastic blood receiving co…

Claim 1

Independent Claim 198 words

The combination of a disposable container and a centrifuge, said combination comprising, a rotor; means defining a generally annularly extending multiportion processing channel in said rotor for processing a suspension including at least one cell component; said channel including one portion for performing a separation function; said channel including another portion for performing another separation function, said other portion being generally spiral-like relative to the true center of said rotor; a disposable plastic suspension-receiving container disposed within said one and other portions of said channel; and fluid connection means at separated locations of said container for introducing the suspension into and extracting at least one suspension component from said container, said fluid connection means including: a first fluid connection means; (a) communicating with the part of said container disposed in said other portion of said channel, (b) being adapted for extracting a first suspension component from the part of said container disposed in said other portion of said channel, and (c) being located at a greater radial distance from the true center of the rotor than the radial distance where the first suspension component enters the part of said container disposed in said other portion of said channel.

Claim 2

Dependent Claim 198 words

The combination of a disposable container and a centrifuge, said combination comprising, a rotor; means defining a generally annularly extending multiportion processing channel in said rotor for processing a suspension including at least one cell component; said channel including one portion for performing a separation function; said channel including another portion for performing another separation function, said other portion being generally spiral-like relative to the true center of said rotor; a disposable plastic suspension-receiving container disposed within said one and other portions of said channel; and fluid connection means at separated locations of said container for introducing the suspension into and extracting at least one suspension component from said container, said fluid connection means including: a first fluid connection means; (a) communicating with the part of said container disposed in said other portion of said channel, (b) being adapted for extracting a first suspension component from the part of said container disposed in said other portion of said channel, and (c) being located at a greater radial distance from the true center of the rotor than the radial distance where the first suspension component enters the part of said container disposed in said other portion of said channel.

Claim 3

Dependent Claim 96 words

The combination of claim 1 wherein said fluid connection means further comprises a second fluid connection means communicating with said container at a location spaced from the true center of rotation of said rotor, for introducing the cell-containing suspension into said container, a third fluid connection means communicating with the part of said container disposed in said one portion of said channel for removing a second suspension component from said container, and a fourth fluid connection means communicating with said container at a selected location for removing a third component of the suspension from said container.

Claim 4

Dependent Claim 23 words

The combination of claim 1 wherein said container is sufficiently flexible to permit insertion into said one and other portions of said channel.

Claim 5

Dependent Claim 15 words

The combination of claim 1 wherein said one portion of said channel is generally circular.

Claim 6

Dependent Claim 14 words

The combination of claim 1 wherein said one portion of said channel is arcuate.

Claim 7

Dependent Claim 35 words

The combination of claim 1 wherein said channel includes radially inner and outer wall surfaces, and a suspension component receiving pocket is defined by said outer wall surface at a selected location in said channel.

Claim 8

Dependent Claim 19 words

The combination of claim 6 wherein said pocket is defined in said one of said portions of said channel.

Claim 9

Dependent Claim 36 words

The combination of claim 7 wherein at least one of said fluid connection means communicates with the interior of said container adjacent said pocket for removing from said container the suspension component collected in said pocket.

Claim 10

Dependent Claim 76 words

The combination of claim 1 wherein said channel includes radially inner and outer wall surfaces, said outer wall surface of said channel including a transition portion of decreasing radius relative to said true center of said rotor, said transition portion being located between said one and said other portions of said channel and defining a generally inwardly extending surface within said channel to restrict the flow of a suspension component between said one and other portions.

Claim 11

Dependent Claim 125 words

The combination of a disposable container and a centrifuge, said combination comprising: a rotor; means providing a generally annularly extending multiportion processing channel in said rotor for processing a suspension including at least one cell component; said channel including one portion for performing a separation function; said channel including another portion for performing another separation function, said other portion being generally spiral-like relative to the true center of said rotor; said multi-portion processing channel having a total arc that is no greater than 360°; a disposable plastic suspension-receiving container disposed within said one and said other portions of said channel; and fluid connection means at separated locations of said container for introducing the suspension into and extracting at least one suspension component from said container.

Claim 12

Dependent Claim 125 words

The combination of a disposable container and a centrifuge, said combination comprising: a rotor; means providing a generally annularly extending multiportion processing channel in said rotor for processing a suspension including at least one cell component; said channel including one portion for performing a separation function; said channel including another portion for performing another separation function, said other portion being generally spiral-like relative to the true center of said rotor; said multi-portion processing channel having a total arc that is no greater than 360°; a disposable plastic suspension-receiving container disposed within said one and said other portions of said channel; and fluid connection means at separated locations of said container for introducing the suspension into and extracting at least one suspension component from said container.

Claim 13

Dependent Claim 124 words

The combination of claim 10 wherein said fluid connection means includes a first fluid connection means communicating with the part of said container disposed within said other portion of said channel for removing a first suspension component from said container, a second fluid connection means communicating with said container at a location spaced from the true center of rotation of said rotor, for introducing the cell-containing suspension into said container, a third fluid connection means communicating with the part of said container disposed in said one portion of said channel for removing a second suspension component from said container, and a fourth fluid connection means communicating with said container at a selected location for removing a third component of the suspension from said container.

Claim 14

Dependent Claim 24 words

The combination of claim 10 wherein said container is sufficiently flexible to permit insertion into said one and said other portions of said channel.

Claim 15

Dependent Claim 15 words

The combination of claim 10 wherein said one portion of said channel is generally circular.

Claim 16

Dependent Claim 14 words

The combination of claim 10 wherein said one portion of said channel is arcuate.

Claim 17

Dependent Claim 35 words

The combination of claim 10 wherein said channel includes radially inner and outer wall surfaces, and a suspension component receiving pocket is defined by said outer wall surface at a selected location in said channel.

Claim 18

Dependent Claim 19 words

The combination of claim 15 wherein said pocket is defined in said one of said portions of said channel.

Claim 19

Dependent Claim 36 words

The combination of claim 16 wherein at least one of said fluid connection means communicates with the interior of said container adjacent said pocket for removing from said container the suspension component collected in said pocket.

Claim 20

Dependent Claim 76 words

The combination of claim 10 wherein said channel includes radially inner and outer wall surfaces, said outer wall surface of said channel including a transition portion of decreasing radius relative to said true center of said rotor, said transition portion being located between said one and said other portions of said channel and defining a generally inwardly extending surface within said channel to restrict the flow of a suspension component between said one and other portions.

Claim 21

Dependent Claim 246 words

The combination of a disposable container and a centrifuge, said combination comprising: a rotor; means providing a generally annularly extending multiportion processing channel in said rotor for processing a suspension including at least one cell component; said channel including one portion for performing a separation function; said channel including another portion for performing another separation function, said other portion being generally spiral-like relative to the true center of said rotor; said multi-portion processing channel having a total arc that is no greater than 360°; a disposable plastic suspension-receiving container disposed within said one and other portions of said channel; fluid connection means at separated locations of said container for introducing the suspension and extracting components of the suspension from said container; said fluid connection means comprising a first fluid connection for introducing the suspension, a second fluid connection for extracting a first suspension component, a third fluid connection for extracting a second suspension component and a fourth fluid connection means for extracting a third component of the suspension; one of said fluid connection means for extracting a suspension component (a) communicating with the part of said container disposed in said other, spiral-like portion of the channel (b) being adapted for extracting a suspension component from said container, and (c) being located at a greater radial distance from the true center of the rotor than the radial distance where the suspension component enters the part of said container disposed in said other, spiral-like portion of said channel.

Claim 22

Dependent Claim 246 words

The combination of a disposable container and a centrifuge, said combination comprising: a rotor; means providing a generally annularly extending multiportion processing channel in said rotor for processing a suspension including at least one cell component; said channel including one portion for performing a separation function; said channel including another portion for performing another separation function, said other portion being generally spiral-like relative to the true center of said rotor; said multi-portion processing channel having a total arc that is no greater than 360°; a disposable plastic suspension-receiving container disposed within said one and other portions of said channel; fluid connection means at separated locations of said container for introducing the suspension and extracting components of the suspension from said container; said fluid connection means comprising a first fluid connection for introducing the suspension, a second fluid connection for extracting a first suspension component, a third fluid connection for extracting a second suspension component and a fourth fluid connection means for extracting a third component of the suspension; one of said fluid connection means for extracting a suspension component (a) communicating with the part of said container disposed in said other, spiral-like portion of the channel (b) being adapted for extracting a suspension component from said container, and (c) being located at a greater radial distance from the true center of the rotor than the radial distance where the suspension component enters the part of said container disposed in said other, spiral-like portion of said channel.

Claim 23

Dependent Claim 23 words

The combination of claim 19 wherein said container is sufficiently flexible to permit insertion into said arcuate and spiral-like portions of said channel.

Claim 24

Dependent Claim 15 words

The combination of claim 19 wherein said one portion of said channel is generally circular.

Claim 25

Dependent Claim 14 words

The combination of claim 19 wherein said one portion of said channel is arcuate.

Claim 26

Dependent Claim 31 words

The combination of claim 19 wherein said channel includes radially inner and outer wall surfaces, and a suspension component receiving pocket is defined by said outer wall surface of said channel.

Claim 27

Dependent Claim 17 words

The combination of claim 23 wherein said pocket is defined in said one portion of said channel.

Claim 28

Dependent Claim 36 words

The combination of claim 24 wherein at least one of said fluid connection means communicates with the interior of said container adjacent said pocket for removing from said container the suspension component collected in said pocket.

Claim 29

Dependent Claim 76 words

The combination of claim 19 wherein said channel includes radially inner and outer wall surfaces, said outer wall surface of said channel including a transition portion of decreasing radius relative to said true center of said rotor, said transition portion being located between said one and said other portions of said channel and defining a generally inwardly extending surface within said channel to restrict the flow of a suspension component between said one and other portions.

Claim 30

Dependent Claim 21 words

The combination of claims 1 or 10 wherein said container comprises two plies of thin-wall flexible material defining a flattened tube.

Claim 31

Dependent Claim 49 words

The combination of claim 27 wherein said two plies are sealed together to define at least two container segments and a flow path communicating between said segments, said plies being heat sealable at said flow path to permit sealing of said flow path and separation of said container segments.

Claim 32

Dependent Claim 27 words

The combination of claim 28 wherein said channel includes a pair of radially inwardly directed walls and said flow path is disposed between said inwardly directed walls.

Claim 33

Dependent Claim 26 words

The combination of claim 27 wherein said two plies are sealed together to define a continuously tapered height along at least a portion of said container.

Claim 34

Dependent Claim 26 words

The combination of claims 1 or 10 wherein said container includes means defining at least two container segments and a flow path communicating between said segments.

Claim 35

Dependent Claim 29 words

The combination of claim 31 wherein said container comprises a plurality of separate spaced apart container segments and a tubing extending between and providing fluid communication between said segments.

Claim 36

Dependent Claim 20 words

The combination of claims 1 or 10 wherein said container has a tapered height along at least a portion thereof.

Claim 37

Dependent Claim 46 words

The combination of claims 1 or 10 wherein at least one of said fluid communication means comprises: means defining an aperture in said container; means defining a filter covering said aperture; and a fluid conduit communicating with the interior of said container through said filter means.

Claim 38

Dependent Claim 39 words

The combination of claim 34 wherein said filter means comprises a filter screen and said fluid conduit comprises a tube attached to said container and having a plurality of perforations therein disposed in direct communication with said filter screen.

Claim 39

Dependent Claim 28 words

The combination of claim 34 wherein said fluid conduit comprises a tube extending from opposite sides of said aperture and looping together to provide a single connect tube.

Claim 40

Dependent Claim 42 words

The combination of claims 1, 11 or 19 wherein the fluid connection means for removing a suspension component from the part of said container disposed in said other portion of said channel is adapted to remove a cell component of the suspension.

Claim 41

Dependent Claim 18 words

The combination of claim 37 wherein the suspension comprises blood and said cell component comprises a blood cell.

Claim 42

Dependent Claim 30 words

The combination of claims 2 or 11 wherein said first suspension component substantially comprises a first cell component and wherein said second suspension component substantially comprises a second cell component.

Claim 43

Dependent Claim 20 words

The combination of claim 39 wherein the suspension comprises blood and the first and second cell components are blood cells.

Claim 44

Dependent Claim 13 words

The combination of claim 40 wherein the third suspension component substantially comprises plasma.

Claim 45

Dependent Claim 18 words

The combination of claims 1, 11 and 19 wherein the suspension includes at least one blood cell component.

Claim 46

Dependent Claim 35 words

The combination of claims 1, 11 or 19 wherein the suspension comprises blood and said container contains a quantity of blood which is relatively small compared to the volume of blood in a human donor.

Claim 47

Dependent Claim 64 words

The combination of claim 1, 10 or 19 wherein said channel is defined by a pair of spaced apart rigid vertical walls, a substantial part of said channel having a height substantially greater than its width along a substantial length of said channel, said channel containing a quantity of blood which is relatively small compared to the volume of blood in a human donor.

Claim 48

Dependent Claim 21 words

The centrifuge assembly of claim 1, 10 or 19 wherein said processing channel has a total arc of less than 180°.

Annuity Stage	Window Opens	Payment Deadline	Surcharge Period Until	Estimated Fee	Status
3.5 Years (Year 4)	1996-06-07	1996-12-07	1997-06-08	$2000.00	Window Closed / Lapsed
7.5 Years (Year 8)	2000-06-07	2000-12-07	2001-06-08	$3760.00	Window Closed / Lapsed
11.5 Years (Year 12)	2004-06-07	2004-12-07	2005-06-08	$7700.00	Window Closed / Lapsed

Combination disposable plastic blood receiving container and blood component centrifuge

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