US5209776A — Tissue bonding and sealing composition and method…

Claim 1

Independent Claim 80 words

A composition for bonding separated tissues together or for coating tissues or prosthetic materials comprising: (a) at least one first component in an amount of at least 4.2% by weight based on the total weight of the composition, said first component being selected from the group consisting of naturally occurring peptides, synthetic peptides, and mixtures thereof; and (b) At least one second component adapted to support the first component to form a matrix, sol or gel with the first component.

Claim 2

Dependent Claim 80 words

A composition for bonding separated tissues together or for coating tissues or prosthetic materials comprising: (a) at least one first component in an amount of at least 4.2% by weight based on the total weight of the composition, said first component being selected from the group consisting of naturally occurring peptides, synthetic peptides, and mixtures thereof; and (b) At least one second component adapted to support the first component to form a matrix, sol or gel with the first component.

Claim 3

Dependent Claim 19 words

The composition of claim 1 wherein the peptides are selected from structural proteins and serum proteins and mixtures thereof.

Claim 4

Dependent Claim 22 words

The composition of claim 1 wherein the amount of the peptide is in the range of from 4.2% to 70% by weight.

Claim 5

Dependent Claim 18 words

The composition of claim 3 wherein the amount of peptide is from about 8 to 35% by weight.

Claim 6

Dependent Claim 18 words

The composition of claim 1 wherein the second component is selected from proteoglycans, saccharides, polyalcohols and mixtures thereof.

Claim 7

Dependent Claim 14 words

The composition of claim 5 wherein the second component is at least one glycosaminoglycan.

Claim 8

Dependent Claim 24 words

The composition of claim 6 wherein the glycosaminoglycans are selected from natural or synthetic non-cellular body matrix materials found in the interstices between cells.

Claim 9

Dependent Claim 28 words

The composition of claim 7 wherein said body matrix materials are selected from hyaluronic acid, salts of hyaluronic acid, chondroitin sulfate, dermatin sulfate, keratin sulfate and heparin sulfate.

Claim 10

Dependent Claim 16 words

The composition of claim 5 wherein the saccharides are selected from fructose, hydroxypropylmethylcellulose, dextrans and agarose.

Claim 11

Dependent Claim 10 words

The composition of claim 5 wherein the polyalcohol is glycerine.

Claim 12

Dependent Claim 22 words

The composition of claim 6 wherein the amount of the glycosaminoglycans is in the range of about 0.1 to 20% by weight.

Claim 13

Dependent Claim 22 words

The composition of claim 5 wherein the amount of the saccharides is in the range of from 0.1 to 70% by weight.

Claim 14

Dependent Claim 23 words

The composition of claim 5 wherein the amount of the polyalcohol is in the range of from about 10 to 90% by weight.

Claim 15

Dependent Claim 19 words

The composition of claim 1 further comprising at least one additive selected from a viscosity modifier and bonding enhancer

Claim 16

Dependent Claim 21 words

The composition of claim 14 wherein the additive is present in an amount of no more than about 65% by weight.

Claim 17

Dependent Claim 29 words

The composition of claim 1 wherein the composition is adapted to bond separated tissues together and has a viscosity in the range of from about 1,000 to 1,000,000 centipoise.

Claim 18

Dependent Claim 31 words

The composition of claim 1 wherein the composition is adapted to coat said tissues or prosthetic materials and has a viscosity in the range of from about 100 to 1,000 centipoise.

Claim 19

Dependent Claim 80 words

A composition for bonding separated tissues together or for coating tissues or prosthetic materials comprising: (a) at least one first component selected from the group consisting of albumin, α-globulins, β-globulins, γ-globulins, transthyretin, collagen, elastin, fibronectin, fibrinogen, fibrin, and thrombin in an amount of at least 4.2% by weight based on the total weight of the composition; and (b) at least one second component adapted to support the first component to form a matrix, sol or gel with the first component.

Claim 20

Dependent Claim 80 words

A composition for bonding separated tissues together or for coating tissues or prosthetic materials comprising: (a) at least one first component selected from the group consisting of albumin, α-globulins, β-globulins, γ-globulins, transthyretin, collagen, elastin, fibronectin, fibrinogen, fibrin, and thrombin in an amount of at least 4.2% by weight based on the total weight of the composition; and (b) at least one second component adapted to support the first component to form a matrix, sol or gel with the first component.

Claim 21

Dependent Claim 88 words

A composition for bonding separated tissues together or for coating tissues or prosthetic materials comprising: (a) at least one first component in an amount of at least about 1.0% by weight based on the total weight of the composition, said first component being selected from the group consisting of naturally occurring peptides, synthetic peptides and mixtures thereof; (b) at least one second component adapted to support the first component to form a matrix, sol or gel with the first component; and (c) at lest one energy absorbing compound.

Claim 22

Dependent Claim 88 words

A composition for bonding separated tissues together or for coating tissues or prosthetic materials comprising: (a) at least one first component in an amount of at least about 1.0% by weight based on the total weight of the composition, said first component being selected from the group consisting of naturally occurring peptides, synthetic peptides and mixtures thereof; (b) at least one second component adapted to support the first component to form a matrix, sol or gel with the first component; and (c) at lest one energy absorbing compound.

Claim 23

Dependent Claim 16 words

The composition of claim 19 wherein the energy absorbing compound is selected from indocyanine and fluorescein.

Claim 24

Dependent Claim 23 words

The composition of claim 19 wherein the energy absorbing compound is present in an amount of from about 0.1 to 50% by weight.

Claim 25

Dependent Claim 80 words

A composition for bonding separated tissues together or for coating tissues or prosthetic materials comprising: (a) albumin, fibrin, fibrinogen or collagen in an amount of 8-35% by weight; (b) hyaluronic acid, sodium salts thereof, or chondroitin sulfate in an amount of 0.1-20% by weight, said composition having a viscosity in the range of from about 1,000 to 200,000 centipoise; and (c) an energy absorption altering compound selected from indocyanine and fluorescein in an amount of from about 0.01-10% by weight.

Claim 26

Dependent Claim 80 words

A composition for bonding separated tissues together or for coating tissues or prosthetic materials comprising: (a) albumin, fibrin, fibrinogen or collagen in an amount of 8-35% by weight; (b) hyaluronic acid, sodium salts thereof, or chondroitin sulfate in an amount of 0.1-20% by weight, said composition having a viscosity in the range of from about 1,000 to 200,000 centipoise; and (c) an energy absorption altering compound selected from indocyanine and fluorescein in an amount of from about 0.01-10% by weight.

Annuity Stage	Window Opens	Payment Deadline	Surcharge Period Until	Estimated Fee	Status
3.5 Years (Year 4)	1996-05-10	1996-11-09	1997-05-11	$2000.00	Window Closed / Lapsed
7.5 Years (Year 8)	2000-05-10	2000-11-09	2001-05-11	$3760.00	Window Closed / Lapsed
11.5 Years (Year 12)	2004-05-10	2004-11-09	2005-05-11	$7700.00	Window Closed / Lapsed

Tissue bonding and sealing composition and method of using the same

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