N-(acylaminomethyl)glutaryl amino acids and use

Claim 2

A compound having the structural formula ##STR41## wherein: R 1 and R 3 are independently selected from the group consisting of hydroxy, lower alkoxy, aryllower alkoxy, amino, lower alkylamino and di-(lower alkyl)amino; R 2 is H or hydroxy; R 4 is aryl, substituted aryl, heteroaryl or substituted heteroaryl; R 6 is H or R 7 --(CH 2 ) 3 --, wherein R 7 is amino or (aryllower alkoxy)carbonylamino; Q is --C(O)-- or --SO 2 --; Y is lower alkyl, lower alkoxy, aryllower alkoxy, amino, lower alkylamino, di-(lower alkyl)amino, or a group of the formula ##STR42## wherein A is a bond, --N(R 5 )--, or --O--; p and r are independently 2 or 3; and wherein R 5 is H or lower alkyl; B is H or Z--(CH 2 ) m -- Z is amino, lower alkylamino, di-(lower alkyl)amino, (aryllower alkoxy)carbonylamino, (lower alkoxy)carbonylamino ##STR43## m=1,2,3,4 or 5; and n=1,2 or 3; or or a pharmaceutically acceptable addition salt thereof.

Claim 3

A compound of claim 1 wherein R 1 and R 3 are hydroxy, R 2 is H, and R 4 is aryl or substituted aryl.

Claim 4

A compound of claim 2 wherein n=2 and R 4 is 4-hydroxyphenyl.

Claim 5

A compound of claim 3 having the structural formula ##STR44## wherein B, Y, Q and R 6 are as defined in claim 1.

Claim 6

A compound of claim 4 wherein B is Z--(CH 2 ) m --, and Z is amino or (aryllower alkoxy)carbonylamino.

Claim 7

A compound of claim 5 wherein R 6 is H, and Y is lower alkoxy, di-(lower alkyl)amino or a group of the formula ##STR45##

Claim 8

A compound of claim 4 wherein B is H, Q is --SO 2 --, and R 6 is R 7 --(CH 2 ) 3 --.

Claim 9

A compound of claim 7 wherein Y is lower alkyl.

Claim 10

A compound of claim 1 having the structural formula __________________________________________________________________________ ##STR46## wherein Compound B R.sup.6 Q Y __________________________________________________________________________ 1 CbzNH(CH.sub.2).sub.4 H C(O) CH.sub.3 O 2 NH.sub.2 (CH.sub.2).sub.4 H C(O) CH.sub.3 O 1A CbzNH(CH.sub.2).sub.4 H C(O) (CH.sub.3).sub.2 NH 2A NH.sub.2 (CH.sub.2).sub.4 H C(O) (CH.sub.3).sub.2 NH 1B CbzNH(CH.sub.2).sub.4 H C(O) ##STR47## 2B NH.sub.2 (CH.sub.2).sub.4 H C(O) ##STR48## 1C CbzNH(CH.sub.2).sub.4 H SO.sub.2 (CH.sub.3).sub.2 NH 2C NH.sub.2 (CH.sub.2).sub.4 H SO.sub.2 (CH.sub.3).sub.2 NH 1D H NH.sub.2 (CH.sub.2).sub.3 SO.sub.2 CH.sub.3 2D H CbzNH(CH.sub.2).sub.3 SO.sub.2 CH.sub.3 __________________________________________________________________________

Claim 11

A pharmaceutical composition useful for treating hypertension, congestive heart failure or renal insufficiency comprising an effective amount of a compound of claim 1 in a pharmaceutically acceptable carrier.

Claim 12

A method of treating hypertension, congestive heart failure or renal insufficiency comprising administering to a mammal in need of such treatment a pharmaceutical composition of claim 10.