EP0474553A1
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Actinonin derivatives
Assignee: Microbial Chemistry Research Foundation
•
Filing: 1991-09-04
•
Granted: —
•
Expires: 2011-09-04
Abstract
Abstract A novel actinonin derivative and a salt thereof are provided, which are useful as enzyme inhibitors and particularly have strong inhibitory activities against enkephalinase and angiotensin-converting enzymes. This actinonin derivative is represented by general formula (I): wherein R¹ is sulfoxymethyl or carboxyl or a substituted carboxyl group selected from carboxamide, hydroxyamino-carbonyl and alkoxycarbonyl groups; and R² is hydroxyl, alkoxy, hydroxyamino or sulfoxyamino group.
Inventors
- 👤 Seiji Pharmaceutical Research Center Shibahara
- 👤 Yoshiyuki Pharmaceutical Research Center Koyama
- 👤 Shigeharu Pharmaceutical Research Center Inoue
- 👤 Mitsugu Pharmaceutical Research Center Hachisu
- 👤 Shinichi Kondo
- 👤 Takaaki Aokagi
- 👤 Tomio Takeuchi
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-05 21:31
CPC Classifications
C; C07; C07D; C07D207/00; C07D207/02; C07D207/04; C07D207/08; A; A61; A61P; A61P43/00; A61P9/00; A61P9/12; C07D207/10; C07D207/16
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
45 words
An actinonin derivative represented by general formula (I): wherein R¹ denotes sulfoxymethyl group or carboxyl group or a substituted carboxyl group selected from carboxamide, hydroxyaminocarbonyl and alkoxycarbonyl groups, and R² denotes hydroxyl group, an alkoxy group, hydroxyamino group or sulfoxyamino group, and a salt thereof.
Claim 2
Dependent Claim
34 words
An actinonin derivative according to Claim 1 and having general formula (I) where R¹ is sulfoxymethyl group -CH₂OSO₃H and R² is sulfoxyamino group -NHOSO₃H, namely said actinonin derivative being (2R)-2-(sulfoxyaminocarbonylmethyl)heptanoyl-L-valyl-(2S)-2-(sulfoxymethyl)pyrrolidine, and a salt thereof.
Claim 3
Dependent Claim
34 words
An actinonin derivative according to Claim 1 and having general formula (I) where R¹ is carboxyl group -COOH and R² is hydroxyamino group -NHOH, namely said actinonin derivative being (2R)-2-(hydroxyaminocarbonyl-methyl)heptanoyl-L-valyl-L-proline, and a salt thereof.
Claim 4
Dependent Claim
36 words
An actinonin derivative according to Claim 1 and having general formula (I) where R¹ is methoxycarbonyl group -COOCH₃ and R² is hydroxyamino group -NHOH, namely said actinonin derivative being (2R)-2-(hydroxyamino-carbonylmethyl)heptanoyl-L-valyl-L-proline methyl ester, and a salt thereof.
Claim 5
Dependent Claim
34 words
An actinonin derivative according to Claim 1 and having general formula (I) where R¹ is hydroxyaminocarbonyl group -CONHOH and R² is hydroxyamino group -NHOH, namely said actinonin derivative being (2R)-2-(hydroxyaminocarbonylmethyl)heptanoyl-L-valyl-L-proline·hydroxamide, and a salt thereof.
Claim 6
Dependent Claim
35 words
An actinonin derivative according to Claim 1 and having general formula (I) where R¹ is hydroxyaminocarbonyl group -CONHOH and R² is methoxy group -OCH₃, namely said actinonin derivative being (2R)-2-(methoxycarbonylmethyl) heptanoyl-L-valyl-L-proline·hydroxamide, and a salt thereof.
Claim 7
Dependent Claim
34 words
An actinonin derivative according to Claim 1 and having general formula (I) where R¹ is hydroxyaminocarbonyl group -CONHOH and R² is hydroxyl group -OH, namely said actinonin derivative being (2R)-2-(carboxymethyl)heptanoyl-L-valyl-L-proline·hydroxamide, and a salt thereof.
Claim 8
Dependent Claim
34 words
An actinonin derivative according to Claim 1 and having general formula where R¹ is sulfoxymethyl group -CH₂OSO₃H and R² is hydroxyamino group -NHOH, namely said actinonin derivative being (2R)-2-(hydroxyamino-carbonylmethyl)heptanoyl-L-valyl-(2S)-2-(sulfoxymethyl) pyrrolidine, and a salt thereof.
References Cited (Backward Citations)
EP0238319A1
Cited
EP0296040A1
Cited
USPTO Annuity & Maintenance Windows
Maintenance schedule is calculated for granted US utility patents.