Patent US5206018A successfully refreshed from Google Patents.
US5206018A
Expired / Lapsed
US
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Use of rapamycin in treatment of tumors
Assignee: Wyeth Canada Inc
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Filing: 1991-10-29
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Granted: 1993-04-27
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Expires: 2011-10-29
Abstract
Abstract This invention provides a method of treating, inhibiting the proliferation of, reducing the size of, or eradicating malignant neoplasms in a mammal in need thereof which comprises administering an antineoplastic amount of rapamycin to said mammal. In particular, rapamycin is useful in treating, inhibiting the proliferation of, reducing the size of, or eradicating malignant mammary and skin carcinomas, and central nervous system neoplasms.
Inventors
- 👤 Surendra N. Sehgal
- 👤 Claude Vezina
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 07:05
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/435; A61K31/44; A61K31/445; A61K31/74; A61K31/765
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
59 words
A method of treating a malignant neoplasm selected from the group consisting of a mammary carcinoma, a skin carcinoma, and a central nervous system neoplasm in a mammal in need thereof which comprises administering an antineoplastic amount of rapamycin to said mammal orally or parenterally with the proviso that said malignant neoplasm has not been transplanted into said mammal.
Claim 2
Independent Claim
59 words
A method of treating a malignant neoplasm selected from the group consisting of a mammary carcinoma, a skin carcinoma, and a central nervous system neoplasm in a mammal in need thereof which comprises administering an antineoplastic amount of rapamycin to said mammal orally or parenterally with the proviso that said malignant neoplasm has not been transplanted into said mammal.
Claim 3
Dependent Claim
26 words
The method of claim 1 wherein the skin carcinoma is selected from the group consisting of a basal cell carcinoma, squamous cell carcinomas, and malignant melanoma.
Claim 4
Dependent Claim
32 words
The method of claim 1 wherein the central nervous system neoplasm is an intracranial neoplasm selected from the group consisting of a meningioma, sarcoma, glioma, astrocytoma, medulloblastoma, schwannoma, ependymoma, meningioma, and germinoma.
Claim 5
Independent Claim
61 words
A method of inhibiting the proliferation of malignant cells selected from the group consisting of a mammary carcinoma, a skin carcinoma, and a central nervous system neoplasm in a mammal in need thereof which comprises administering an antineoplastic amount of rapamycin to said mammal orally or parenterally with the proviso that said malignant cells have not been transplanted into said mammal.
Claim 6
Independent Claim
61 words
A method of inhibiting the proliferation of malignant cells selected from the group consisting of a mammary carcinoma, a skin carcinoma, and a central nervous system neoplasm in a mammal in need thereof which comprises administering an antineoplastic amount of rapamycin to said mammal orally or parenterally with the proviso that said malignant cells have not been transplanted into said mammal.
Claim 7
Dependent Claim
26 words
The method of claim 4 wherein the skin carcinoma is selected from the group consisting of a basal cell carcinoma, squameous cell carcinomas, and malignant melanoma.
Claim 8
Dependent Claim
32 words
The method of claim 4 wherein the central nervous system neoplasm is an intracranial neoplasm selected from the group consisting of a meningioma, sarcoma, glioma, astrocytoma, medulloblastoma, schwannoma, ependymoma, meningioma, and germinoma.
Claim 9
Independent Claim
62 words
A method of reducing the size of a malignant neoplasm selected from the group consisting of a mammary carcinoma, a skin carcinoma, and a central nervous system neoplasm in a mammal in need thereof which comprises administering an antineoplastic amount of rapamycin to said mammal orally or parenterally with the proviso that said malignant neoplasm has not been transplanted into said mammal.
Claim 10
Independent Claim
62 words
A method of reducing the size of a malignant neoplasm selected from the group consisting of a mammary carcinoma, a skin carcinoma, and a central nervous system neoplasm in a mammal in need thereof which comprises administering an antineoplastic amount of rapamycin to said mammal orally or parenterally with the proviso that said malignant neoplasm has not been transplanted into said mammal.
Claim 11
Dependent Claim
26 words
The method of claim 7 wherein the skin carcinoma is selected from the group consisting of a basal cell carcinoma, squameous cell carcinomas, and malignant melanoma.
Claim 12
Dependent Claim
32 words
The method of claim 7 wherein the central nervous system neoplasm is an intracranial neoplasm selected from the group consisting of a meningioma, sarcoma, glioma, astrocytoma, medulloblastoma, schwannoma, ependymoma, meningioma, and germinoma.
Claim 13
Independent Claim
59 words
A method of eradicating a malignant neoplasm selected from the group consisting of a mammary carcinoma, a skin carcinoma, and a central nervous system neoplasm in a mammal in need thereof which comprises administering an antineoplastic amount of rapamycin to said mammal orally or parenterally with the proviso that said malignant neoplasm has not been transplanted into said mammal.
Claim 14
Independent Claim
59 words
A method of eradicating a malignant neoplasm selected from the group consisting of a mammary carcinoma, a skin carcinoma, and a central nervous system neoplasm in a mammal in need thereof which comprises administering an antineoplastic amount of rapamycin to said mammal orally or parenterally with the proviso that said malignant neoplasm has not been transplanted into said mammal.
Claim 15
Dependent Claim
26 words
The method of claim 10 wherein the skin carcinoma is selected from the group consisting of a basal cell carcinoma, squameous cell carcinomas, and malignant melanoma.
Claim 16
Dependent Claim
32 words
The method of claim 10 wherein the central nervous system neoplasm is an intracranial neoplasm selected from the group consisting of a meningioma, sarcoma, glioma, astrocytoma, medulloblastoma, schwannoma, ependymoma, meningioma, and germinoma.
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