Abstract The present invention provides digoxigenin derivatives of the formula: ##STR1## wherein n is a whole number of from 1 to 4 and Z is a carboxyl group or a functional derivative derived therefrom. The present invention also provides digoxigenin conjugates of the general formula: ##STR2## wherein the carrier is an immunogenic carrier material, a nucleic acid or a labelled immunocomponent of a labelled digoxigenin immunoconjugate for use in an immunoassay, m is a number from 1 to the number of coupling positions available on the carrier and Y is the group formed by the reaction of the carboxyl function Z of the digoxigenin derivative of general formula (I) with the reacting position of the carrier material. Also described are uses of these conjugates as nucleic acid probes, immunogens, and in immunoassay.
Digoxigenin derivative of formula: ##STR9## wherein n is a whole number from 1 to 4, and Z is --CN, --COOC 2 H 5 , ##STR10##
Claim 2
Dependent Claim
25 words
Digoxigenin derivative of formula: ##STR9## wherein n is a whole number from 1 to 4, and Z is --CN, --COOC 2 H 5 , ##STR10##
Claim 3
Dependent Claim
9 words
Digoxigenin derivative of claim 1, wherein n is 1.
Claim 4
Dependent Claim
48 words
Digoxigenin conjugate of the formula: ##STR11## wherein said carrier is an immunogenic protein or polypeptide, a nucleic acid or a labelled immunocomponent of a labelled digoxigenin immunoconjugate, m is a whole number from 1 to the number of coupling positions available on said carrier, and Y is ##STR12##
Claim 5
Dependent Claim
48 words
Digoxigenin conjugate of the formula: ##STR11## wherein said carrier is an immunogenic protein or polypeptide, a nucleic acid or a labelled immunocomponent of a labelled digoxigenin immunoconjugate, m is a whole number from 1 to the number of coupling positions available on said carrier, and Y is ##STR12##
Claim 6
Dependent Claim
14 words
Digoxigenin conjugate of claim 3, wherein said carrier is an immunogenic protein or polypeptide.
Claim 7
Dependent Claim
12 words
Digoxigenin conjugate of claim 3, wherein said carrier is a nucleic acid.
Claim 8
Dependent Claim
12 words
Digoxigenin conjugate of claim 3, wherein said carrier is a labelled immunocomponent.