US3855208A
Expired / Lapsed
US
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Derivatives of digoxigenin
Assignee: Becton Dickinson and Co
•
Filing: 1971-05-24
•
Granted: 1974-12-17
•
Expires: 1991-05-24
Abstract
Abstract Derivatives of digoxigenin which are either unlabeled or radioiodinated having the following structural formula: WHEREIN R'' is hydroxyl or acetoxy; B is succinyl, phthaloyl, maleyl or fumaryl, preferably succinyl, and X is hydroxyl or alkali metal salt thereof; a protein conjugate; a peptide conjugate; or an amino acid or amino acid ester radical. The radiolabeled compounds are used in the radioimmunological assay of digoxin. The preferred compound is radioiodinated 3succinyl digoxigenin-L-tyrosine.
Inventors
- 👤 H Rutner
- 👤 R Rapun
- 👤 N Lewin
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 23:16
CPC Classifications
C; C07; C07J; C07J19/00; C07J21/00
Claims Analysis
Total Claims: 39
Claim 1
Independent Claim
12 words
A COMPOSITION OF MATTER COMPRISING A COMPOUND HAVING THE FOLLOWING STRUCTURAL FORMULA:
Claim 2
Dependent Claim
12 words
A COMPOSITION OF MATTER COMPRISING A COMPOUND HAVING THE FOLLOWING STRUCTURAL FORMULA:
Claim 3
Dependent Claim
24 words
The composition of matter as defined in claim 1 wherein X is an unlabeled amino acid radical as defined in (e) of claim 1.
Claim 4
Dependent Claim
24 words
The composition of matter as defined in claim 1 wherein X is a radioiodinated amino acid radical as defined in (e) of claim 1.
Claim 5
Dependent Claim
12 words
A composition of matter comprising a compound having the following structural formula:
Claim 6
Dependent Claim
12 words
A composition of matter comprising a compound having the following structural formula:
Claim 7
Dependent Claim
13 words
The composition of matter as defined in claim 4 wherein R'' is -OCOCH3.
Claim 8
Dependent Claim
17 words
The composition of matter as defined in claim 5 wherein X is an unlabeled amino acid radical.
Claim 9
Dependent Claim
13 words
The composition of matter as defined in claim 6 wherein R2 is hydrogen.
Claim 10
Dependent Claim
17 words
The composition of matter as defined in claim 5 wherein X is a radioiodinated amino acid radical.
Claim 11
Dependent Claim
13 words
The composition of matter as defined in claim 8 wherein R2 is hydrogen.
Claim 12
Dependent Claim
13 words
The composition of matter as defined in claim 4 wherein R'' is -OH.
Claim 13
Dependent Claim
17 words
The composition of matter as defined in claim 10 wherein X is an unlabeled amino acid radical.
Claim 14
Dependent Claim
13 words
The composition of matter as defined in claim 11 wherein R2 is hydrogen.
Claim 15
Dependent Claim
17 words
The composition of matter as defined in claim 10 wherein X is a radioiodinated amino acid radical.
Claim 16
Dependent Claim
13 words
The composition of matter as defined in claim 13 wherein R2 is hydrogen.
Claim 17
Dependent Claim
16 words
The composition of matter as defined in claim 4 wherein the compound is radioiodinated 3-succinyl digoxigenin-L-tyrosine.
Claim 18
Dependent Claim
19 words
The composition of matter as defined in claim 4 wherein the compound is radioiodinated 3-succinyl digoxigenin-L-tyrosine lower alkyl ester.
Claim 19
Dependent Claim
16 words
The composition of matter as defined in claim 4 wherein the compound is radioiodinated 3-succinyl digoxigenin-histidine.
Claim 20
Dependent Claim
19 words
The composition of matter as defined in claim 4 wherein the compound is radioiodinated 3-succinyl digoxigenin-histidine lower alkyl ester.
Claim 21
Dependent Claim
16 words
The composition of matter as defined in claim 4 wherein the compound is radioiodinated 3-succinyl digoxigenin-4-hydroxyphenylglycine.
Claim 22
Dependent Claim
19 words
The composition of matter as defined in claim 4 wherein the compound is radioiodinated 3-succinyl digoxigenin-4-hydroxyphenylglycine lOwer alkyl ester.
Claim 23
Dependent Claim
16 words
The composition of matter as defined in claim 4 wherein the compound is 3-succinyl digoxigenin tyrosine.
Claim 24
Dependent Claim
19 words
The composition of matter as defined in claim 4 wherein the compound is 3-succinyl digoxigenin tyrosine lower alkyl ester.
Claim 25
Dependent Claim
14 words
The composition of matter as defined in claim 4 wherein the compound is 3-succinyl-digoxigenin-histidine.
Claim 26
Dependent Claim
17 words
The composition of matter as defined in claim 4 wherein the compound is 3-succinyl-digoxigenin-histidine lower alkyl ester.
Claim 27
Dependent Claim
14 words
The composition of matter as defined in claim 4 wherein the compound is 3-succinyl-digoxigenin-4-hydroxyphenyl-glycine.
Claim 28
Dependent Claim
18 words
The composition of matter as defined in claim 4 wherein the compound is 3-succinyl digoxigenin-4-hydroxyphenyl-glycine lower alkyl ester.
Claim 29
Dependent Claim
11 words
A process for producing a compound having the following structural formula:
Claim 30
Dependent Claim
11 words
A process for producing a compound having the following structural formula:
Claim 31
Dependent Claim
9 words
The process of claim 27 wherein B is succinyl.
Claim 32
Dependent Claim
33 words
The process of claim 28 wherein R2 in the starting compound and product is lower alkyl and the base is selected from the group consisting of sodium hydrogen carbonate and potassium hydrogen carbonate.
Claim 33
Dependent Claim
14 words
The process of claim 29 wherein the solvent is a C1 to C5 alkanol.
Claim 34
Dependent Claim
14 words
The process of claim 29 wherein the temperature is from 20* to 25* C.
Claim 35
Dependent Claim
13 words
The process of claim 30 wherein the product is 3-succinyl digoxigenin-L-tyrosine methyl ester.
Claim 36
Dependent Claim
27 words
The process of claim 28 wherein R2 in the product is hydrogen and the base is selected from the group consisting of sodium carbonate and potassium carbonate.
Claim 37
Dependent Claim
14 words
The process of claim 33 wherein the temperature is from 20* to 25* C.
Claim 38
Dependent Claim
14 words
The process of claim 33 wherein the solvent is a C1 to C5 alkanol.
Claim 39
Dependent Claim
11 words
The process of claim 35 wherein the product is 3-succinyl digoxigenin-L-tyrosine.
References Cited (Backward Citations)
US3068229A
Cited
US3655643A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1977-12-16 | 1978-06-17 | 1978-12-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1981-12-16 | 1982-06-17 | 1982-12-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1985-12-16 | 1986-06-17 | 1986-12-17 | $7700.00 | Window Closed / Lapsed |