US4082747A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Chemical process
Assignee: Mallinckrodt Chemical Inc
•
Filing: 1975-10-01
•
Granted: 1978-04-04
•
Expires: 1995-10-01
Abstract
Abstract An improved process for coupling an amino acid or derivative thereof to a cardiotonic glycoside derivative.
Inventors
- 👤 Jong C. Chen
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 23:27
CPC Classifications
C; C07; C07J; C07J19/00; C07J19/005; C07J41/00; C07J41/0033; C07J41/0055
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
35 words
In a process for coupling tyrosine or tyrosine methyl ester to 3-carbodigoxigenin glycine, 3-hemiadipyl digoxigenin or digoxigenin-12-acetate-3-hemisuccinate in an inert solvent utilizing an agnet to affect coupling, the improvement comprising utilizing as the agent dicyclohexylcarbodiimide.
Claim 2
Dependent Claim
35 words
In a process for coupling tyrosine or tyrosine methyl ester to 3-carbodigoxigenin glycine, 3-hemiadipyl digoxigenin or digoxigenin-12-acetate-3-hemisuccinate in an inert solvent utilizing an agnet to affect coupling, the improvement comprising utilizing as the agent dicyclohexylcarbodiimide.
Claim 3
Dependent Claim
25 words
A process according to claim 1 wherein said dicyclohexylcarbodiimide is used in an amount from about 1 to 2 moles per mole of digoxigenin derivative.
Claim 4
Dependent Claim
18 words
A process according to claim 2 wherein the reaction temperature is from about 10° to about 40° C.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-04-03 | 1981-10-03 | 1982-04-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-04-03 | 1985-10-03 | 1986-04-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-04-03 | 1989-10-03 | 1990-04-04 | $7700.00 | Window Closed / Lapsed |