US4013688A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Radioimmunoassay agents
Assignee: Pharmacia and Upjohn Co
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Filing: 1972-12-20
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Granted: 1977-03-22
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Expires: 1992-12-20
Abstract
Abstract Novel steroid derivatives containing a tyrosine ester amide group linked to an 11-hydroxysteroid alkylene dicarboxylic hemi-ester are described, suitable for iodination with radioactive iodine, useful in radioimmunoassay.
Inventors
- 👤 John C. Babcock
- 👤 J. Allan Campbell
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 18:52
CPC Classifications
C; C07; C07J; C07J41/00; C07J41/0033; C07J41/0094; C07J1/00; C07J1/0003; C07J1/0011; C07J1/0018; C07J1/0022; C07J1/0033; C07J1/0037; C07J1/0051; C07J1/0059; C07J1/0066; C07J1/007; C07J41/005; C07J41/0072; C07J5/00; C07J5/0007; C07J5/0015; C07J53/00; C07J7/00; C07J7/0005; C07J7/001; C07J7/0015; C07J7/002; C07J7/004; C07J7/0045; C07J7/0065; C07J7/007
Claims Analysis
Total Claims: 2
Claim 1
Independent Claim
69 words
A compound having the following structural formula ##STR15## wherein St is a steroid moiety linked through the 11-carbon atom and selected from the group consisting of those moieties corresponding to 2α -hydroxypregn-4-en-3-one 20β-hydroxypregn-4-en-3-one 17α-hydroxypregn-4-ene-3,20-dione 21-hydroxypregn-4-ene-3,20-dione 17α,21-dihydroxypregn-4-ene-3,20-dione 17β-hydroxyandrost-4-en-3-one (testosterone) 17β-hydroxy-5α-androstan-3-one 17β-hydroxy-5β-androstan-3-one 5α-androstane-3β,17β-diol 17β-hydroxyestr-4-en-3-one (19-nortestosterone) estrone estradiol estriol estr-5-ene-3β,17β-diol androst-5-ene-3β,17β-diol dehydroepiandrosterone pregnenolone 21-hydroxypregnenolone 17α-hydroxypregnenolone 17,21-dihydroxypregnenolone 17β,17α-dimethyl-17-hydroxyandrost-4-en-3-one, and R is a lower alkyl group containing from 1 to 6 carbon atoms inclusive.
Claim 2
Dependent Claim
69 words
A compound having the following structural formula ##STR15## wherein St is a steroid moiety linked through the 11-carbon atom and selected from the group consisting of those moieties corresponding to 2α -hydroxypregn-4-en-3-one 20β-hydroxypregn-4-en-3-one 17α-hydroxypregn-4-ene-3,20-dione 21-hydroxypregn-4-ene-3,20-dione 17α,21-dihydroxypregn-4-ene-3,20-dione 17β-hydroxyandrost-4-en-3-one (testosterone) 17β-hydroxy-5α-androstan-3-one 17β-hydroxy-5β-androstan-3-one 5α-androstane-3β,17β-diol 17β-hydroxyestr-4-en-3-one (19-nortestosterone) estrone estradiol estriol estr-5-ene-3β,17β-diol androst-5-ene-3β,17β-diol dehydroepiandrosterone pregnenolone 21-hydroxypregnenolone 17α-hydroxypregnenolone 17,21-dihydroxypregnenolone 17β,17α-dimethyl-17-hydroxyandrost-4-en-3-one, and R is a lower alkyl group containing from 1 to 6 carbon atoms inclusive.
References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-03-21 | 1980-09-20 | 1981-03-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-03-21 | 1984-09-20 | 1985-03-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-03-21 | 1988-09-20 | 1989-03-22 | $7700.00 | Window Closed / Lapsed |