US5162303A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Pharmaceutical compositions containing prolactin and methods for the use thereof
Assignee: Amiad Research and Development
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Filing: 1990-10-04
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Granted: 1992-11-10
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Expires: 2010-10-04
Abstract
Abstract The invention provides a pharmaceutical composition for increasing the tensile strength of connective tissue while modifying the amount of cross-linked collagen therein comprising prolactin in an amount effective to increase the tensile strength of connective tissue as active ingredient therein in combination with a pharmacologically acceptable carrier.
Inventors
- 👤 Geoffrey Goodman
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 15:35
CPC Classifications
A; A61; A61K; A61K38/00; A61K38/16; A61K38/17; A61K38/22; A61K38/2257; A61K31/00; A61K31/33; A61K31/335; A61K31/365; A61K31/375
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
42 words
A pharmaceutical composition comprising an effective amount of prolactin; ascorbic acid or an ascorbate; and a pharmacologically acceptable carrier; wherein the amounts of prolactin and ascorbic acid or ascorbate are effective to modify the amount of Type III collagen in connective tissue.
Claim 2
Dependent Claim
42 words
A pharmaceutical composition comprising an effective amount of prolactin; ascorbic acid or an ascorbate; and a pharmacologically acceptable carrier; wherein the amounts of prolactin and ascorbic acid or ascorbate are effective to modify the amount of Type III collagen in connective tissue.
Claim 3
Dependent Claim
14 words
A pharmaceutical composition according to claim 3 wherein the composition is in topical form.
Claim 4
Dependent Claim
18 words
A pharmaceutical composition according to claim 3 wherein said active ingredient and carrier are formulated for internal administration.
Claim 5
Dependent Claim
18 words
A pharmaceutical composition according to claim 3 wherein said connective tissue is connective tissue of the skeletal system.
Claim 6
Dependent Claim
15 words
A pharmaceutical composition according to claim 3 wherein said connective tissue is cardiovascular connective tissue.
Claim 7
Dependent Claim
18 words
A pharmaceutical composition according to claim 3 wherein said connective tissue is connective tissue of the gastrointestinal tract.
Claim 8
Dependent Claim
37 words
A pharmaceutical composition comprising an effective amount of prolactin; ascorbic acid or an ascorbate; and a pharmacologically acceptable carrier; wherein the amounts of prolactin and ascorbic acid or ascorbate are effective for promoting wound and tissue healing.
Claim 9
Dependent Claim
37 words
A pharmaceutical composition comprising an effective amount of prolactin; ascorbic acid or an ascorbate; and a pharmacologically acceptable carrier; wherein the amounts of prolactin and ascorbic acid or ascorbate are effective for promoting wound and tissue healing.
Claim 10
Dependent Claim
18 words
A pharmaceutical composition according to claim 7 wherein said active ingredient and carrier are formulated for internal administration.
Claim 11
Dependent Claim
18 words
A pharmaceutical composition according to claim 7 wherein said connective tissue is connective tissue of the gastrointestinal tract.
Claim 12
Dependent Claim
50 words
A pharmaceutical composition comprising an effective amount of a combination of prolactin and ascorbic acid or prolactin and an ascorbate as active ingredients therein, together with a pharmacologically acceptable carrier wherein the amounts of prolactin and ascorbic acid or ascorbate are effective to increase the tensile strength of connective tissue.
Claim 13
Dependent Claim
50 words
A pharmaceutical composition comprising an effective amount of a combination of prolactin and ascorbic acid or prolactin and an ascorbate as active ingredients therein, together with a pharmacologically acceptable carrier wherein the amounts of prolactin and ascorbic acid or ascorbate are effective to increase the tensile strength of connective tissue.
Claim 14
Dependent Claim
18 words
A pharmaceutical composition according to claim 17 wherein said active ingredient and carrier are formulated for internal administration.
Claim 15
Dependent Claim
18 words
A pharmaceutical composition according to claim 17 wherein said connective tissue is connective tissue of the gastrointestinal tract.
Claim 16
Independent Claim
46 words
A method for protecting and restoring skin connective tissue in a mammalian or avian species comprising applying a topical cosmetic composition comprising prolactin in an amount effective to increase the tensile strength of connective tissue as active ingredient therein in combination with a pharmacologically acceptable carrier.
Claim 17
Independent Claim
46 words
A method for protecting and restoring skin connective tissue in a mammalian or avian species comprising applying a topical cosmetic composition comprising prolactin in an amount effective to increase the tensile strength of connective tissue as active ingredient therein in combination with a pharmacologically acceptable carrier.
Claim 18
Independent Claim
51 words
A method for protecting and restoring connective tissue in a mammalian or avian species comprising internally administering to said mammalian or avian species a pharmaceutical composition comprising prolactin in an amount effective to increase the tensile strength of connective tissue as active ingredient therein in combination with a pharmacologically acceptable carrier.
Claim 19
Independent Claim
51 words
A method for protecting and restoring connective tissue in a mammalian or avian species comprising internally administering to said mammalian or avian species a pharmaceutical composition comprising prolactin in an amount effective to increase the tensile strength of connective tissue as active ingredient therein in combination with a pharmacologically acceptable carrier.
Claim 20
Independent Claim
48 words
A method for increasing the tensile strength of connective tissue in a mammalian or avian species comprising administering to said mammalian or avian species a pharmaceutical composition containing an effective amount of a combination of prolactin and ascorbic acid or prolactin and an ascorbate as active ingredients therein.
Claim 21
Independent Claim
48 words
A method for increasing the tensile strength of connective tissue in a mammalian or avian species comprising administering to said mammalian or avian species a pharmaceutical composition containing an effective amount of a combination of prolactin and ascorbic acid or prolactin and an ascorbate as active ingredients therein.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-11-10 | 1996-05-11 | 1996-11-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-11-10 | 2000-05-11 | 2000-11-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-11-10 | 2004-05-11 | 2004-11-10 | $7700.00 | Window Closed / Lapsed |