US3887705A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Medicaments intended for the prevention and treatment of capillary-venous deficiencies
Assignee: Pierre Fabre SA
•
Filing: 1973-05-17
•
Granted: 1975-06-03
•
Expires: 1993-05-17
Abstract
Abstract The present invention relates to new compositions which are useful as medicaments. These new compositions contain dihydroergotamine, one or more vitamin P factors and a vitamin C factor. They are useful in the prevention and treatment of disturbances of the vein wall, particularly the orthostatic syndrome.
Inventors
- 👤 Hubert Serre
- 👤 Jean Rey
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 08:07
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/70; A61K31/7042; A61K31/7048
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
79 words
PHARMACEUTICAL COMPOSITION USEFUL IN THE PREVENTION AND TREATMENT OF CIRCULATORY DISTURBANCES COMPRISING IN EFFECTIVE AMOUNTS A. DIHYDROERGOTAMINE OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, B. AT LEAST ONE VITAMIN P COMPOUND, AND C. ASCORBIC ACID (VITAMIN C) IN A FORM USEFUL IN MEDICAMENTS, WHEREIN SAID COMPONENTS (A), (B) AND (C) ARE PRESENT IN AMOUNTS SO AS TO PROVIDE THE COMPONENTS IN A PROPORTION BY WEIGHT OF ABOUT 2 PARTS OF (A), 10-150 PARTS OF (B), AND 30-350 PARTS OF (C).
Claim 2
Dependent Claim
79 words
PHARMACEUTICAL COMPOSITION USEFUL IN THE PREVENTION AND TREATMENT OF CIRCULATORY DISTURBANCES COMPRISING IN EFFECTIVE AMOUNTS A. DIHYDROERGOTAMINE OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, B. AT LEAST ONE VITAMIN P COMPOUND, AND C. ASCORBIC ACID (VITAMIN C) IN A FORM USEFUL IN MEDICAMENTS, WHEREIN SAID COMPONENTS (A), (B) AND (C) ARE PRESENT IN AMOUNTS SO AS TO PROVIDE THE COMPONENTS IN A PROPORTION BY WEIGHT OF ABOUT 2 PARTS OF (A), 10-150 PARTS OF (B), AND 30-350 PARTS OF (C).
Claim 3
Dependent Claim
79 words
Pharmaceutical composition useful in the prevention and treatment of circulatory disturbances comprising in effective amounts a. dihydroergotamine or a pharmaceutically acceptable salt thereof, b. at least one vitamin P compound, and c. ascorbic acid (vitamin C) in a form useful in medicaments, wherein said components (a), (b) and (c) are present in amounts so as to provide the components in a proportion by weight of about 2 parts of (a), 10-150 parts of (b), and 30-350 parts of (c).
Claim 4
Dependent Claim
79 words
Pharmaceutical composition useful in the prevention and treatment of circulatory disturbances comprising in effective amounts a. dihydroergotamine or a pharmaceutically acceptable salt thereof, b. at least one vitamin P compound, and c. ascorbic acid (vitamin C) in a form useful in medicaments, wherein said components (a), (b) and (c) are present in amounts so as to provide the components in a proportion by weight of about 2 parts of (a), 10-150 parts of (b), and 30-350 parts of (c).
Claim 5
Dependent Claim
12 words
Pharmaceutical composition in accord with claim 1 in a delayed-action pharmaceutical form.
Claim 6
Dependent Claim
41 words
Pharmaceutical composition in accord with claim 1 wherein said components are present in amounts so as to provide the components in a proportion of about 2 milligrams of (a) to about 150 milligrams of (b) and about 350 milligrams of (c).
Claim 7
Dependent Claim
28 words
Pharmaceutical composition in accord with claim 1 wherein the vitamin P compound is selected from the group consisting of trihydroxy ethyl rutin, hesperidine methyl chalcone, and methyl-4-esculetol monoethanolate.
Claim 8
Dependent Claim
19 words
Composition in accord with claim 4 comprising (a) dihydroeRgotamine methane sulfonate, (b) trihydroxy ethyl rutin, and (c) ascorbic acid.
Claim 9
Dependent Claim
19 words
Composition in accord with claim 4 comprising (a) dihydroergotamine methane sulfonate, (b) hesperidin methyl chalcone, and (c) magnesium ascorbate.
Claim 10
Dependent Claim
19 words
Composition in accordance with claim 4 comprising (a) dihydroergotamine methane sulfonate, (b) hesperidin methyl chalcone, and (c) sodium ascorbate.
Claim 11
Dependent Claim
22 words
Composition in accordance with claim 4 comprising (a) dihydroergotamine methane sulfonate, (b) hesperidin methyl chalcone, and methyl-4-esculetol monoethanolate, and (c) ascorbic acid.
Claim 12
Dependent Claim
46 words
Composition in accordance with claim 8 comprising the ingredients (a), (b) and (c) thereof in a proportion of (a) about 2 milligrams of dihydroergotamine, (b) about 130 milligrams of hesperidin methyl chalcone, about 20 milligrams of methyl-4-esculetol monoethanolate and (c) about 350 milligrams of vitamin C.
Claim 13
Dependent Claim
43 words
A method for the prevention and treatment of circulatory disturbances of the vein wall and the orthostatic syndrome which comprises administering to a patient subject to such circulatory disturbance an amount of the composition of claim 1 effective for alleviation of such condition.
Claim 14
Dependent Claim
35 words
A method for the prevention and treatment of circulatory disturbances which comprises administering to a patient suffering from such circulatory disturbance an amount of the composition of claim 3 effective for alleviation of such condition.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-06-02 | 1978-12-02 | 1979-06-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-06-02 | 1982-12-02 | 1983-06-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-06-02 | 1986-12-02 | 1987-06-03 | $7700.00 | Window Closed / Lapsed |