EP0046409A1
Expired / Lapsed
EP
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A process for the preparation of a solution of a cuprous complex; solutions of the cuprous complexes for use in the therapeutic treatment of the human or animal body; and a method of therapeutic treatment of a plant
Assignee: Individual
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Filing: 1981-08-19
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Granted: —
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Expires: 2001-08-19
Abstract
Abstract A solution of a cuprous complex is prepared by a process in which a cupric halide is dissolved in a solvent consisting of one or more of ethyl alcohol or a liquid primary alcohol containing 3 or more carbon atoms, polypropylene glycol, propylene glycol, polyethylene glycol, ethylene gly- color other liquid glycol, glycerol or other liquid triol, an aliphatic betaine and a sulphobetaine, the concentration of Cu being not less than 0.01 % w/v; ascorbic acid not less than 90% of the weight of the Cu present or the equivalent weight of a non-toxic ascorbate, is added and dissolved under an inert atmosphere; and the pH of this solution, if less than 4, is adjusted to 4 to 6 by the addition of an alkali. The solutions of the cuprous complexes are useful in the topical therapeutic treatment of the human or animal body suffering from any of fungal, imflammatory or viral complaints, arthritis, rheumatism, warts, herpes or carcinoma; papiloma; and also in the topical treatment of plants affected with fungal disorders.
Inventors
- 👤 Erwin Günther Walliczek
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-28 16:14
CPC Classifications
C; C07; C07F; C07F1/00; C07F1/005; A; A01; A01N; A01N43/00; A01N43/02; A01N43/04; A01N43/06; A01N43/08; A61; A61K; A61K31/00; A61K31/33; A61K31/335; A61K31/365; A61K31/375; A61P; A61P17/00; C07C; C07C51/00; C07C51/41; C07C51/418
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
131 words
A process for the preparation of a solution of a cuprous complex characterised in that (a) a cupric halide is dissolved in a solvent consisting of one or more of ethyl alcohol or a liquid primary alcohol containing 3 or more carbon atoms, polypropylene glycol, propylene glycol, polyethylene glycol, ethylene glycol or other liquid glycol, glycerol.or other liquid triol, an aliphatic betaine and a sulpho-betaine the concentration of Cu being not less than 0.01% w/v of said solution; (b) ascorbic acid not less than 90% of the weight of the Cu present or the equivalent weight of a non-toxic ascorbate, is added and dissolved under an inert atmosphere; and (c) the pH of this solution, if less than 4, is adjusted to 4 to 6 by the addition of an alkali.
Claim 2
Dependent Claim
131 words
A process for the preparation of a solution of a cuprous complex characterised in that (a) a cupric halide is dissolved in a solvent consisting of one or more of ethyl alcohol or a liquid primary alcohol containing 3 or more carbon atoms, polypropylene glycol, propylene glycol, polyethylene glycol, ethylene glycol or other liquid glycol, glycerol.or other liquid triol, an aliphatic betaine and a sulpho-betaine the concentration of Cu being not less than 0.01% w/v of said solution; (b) ascorbic acid not less than 90% of the weight of the Cu present or the equivalent weight of a non-toxic ascorbate, is added and dissolved under an inert atmosphere; and (c) the pH of this solution, if less than 4, is adjusted to 4 to 6 by the addition of an alkali.
Claim 3
Dependent Claim
20 words
A process as claimed in Claim 1 wherein the cupric halide is dissolved at a temperature between 60°C and 80°C.
Claim 4
Dependent Claim
60 words
A process as claimed in Claim 1 or 2 wherein the cupric halide is CuCl 2 .2H 2 O, the non-toxic ascorbate is sodium ascorbate, the weight of ascorbic acid is 100% of the weight of the Cu present or the weight of sodium ascorbate is 112.5% of the weight of the Cu present, and the inert atmosphere is nitrogen.
Claim 5
Dependent Claim
37 words
A process as claimed in any preceding claim wherein the solvent is an aliphatic betaine having a pH between 3.5 and 6.0, a sulpho-betaine having a pH between 3.5 and 6.0 or a mixture of the two.
Claim 6
Dependent Claim
19 words
A process as claimed in any preceding claim., wherein the solution is additionally diluted with a pharmaceutically acceptable diluent.
Claim 7
Dependent Claim
52 words
A solution of a cuprous complex when produced by a process as claimed in any preceding claim, characterised in that the solution is for use in the topical therapeutic treatment of the human or animal body suffering from any of, fungal, inflammatory or viral complaints; arthritis, rheumatism, warts, herpes or carcinoma; papiloma.
Claim 8
Dependent Claim
59 words
A solution according to claim 6, wherein an aliphatic betaine or a sulpho-betaine is present, and characterised in that the solution is for use in the topical therapeutic treatment of the human or animal body also suffering from a bacterial infection associated with any of the said fungal, inflammatory or viral complaints; arthritis, rheumatism, warts, herpes or carcinoma; papiloma.
Claim 9
Independent Claim
37 words
A method of therapeutic treatment of a plant afflicted with a disability caused by a fungus, characterised by topical application of a solution produced by a process as claimed in any one of Claims 1 to 5.
Claim 10
Dependent Claim
3 words
CLAIMS: (for Austria)
Claim 11
Dependent Claim
131 words
A process for the preparation of a solution of a cuprous complex characterised in that (a) a cupric halide is dissolved in a solvent consisting of one or more of ethyl alcohol or a liquid primary alcohol containing 3 or more carbon atoms, polypropylene glycol, propylene glycol, polyethylene glycol, ethylene glycol or other liquid glycol, glycerol.or other liquid triol, an aliphatic betaine and a sulpho-betaine the concentration of Cu being not less than 0.01% w/v of said solution; (b) ascorbic acid not less than 90% of the weight of the Cu present or the equivalent weight of a non-toxic ascorbate, is added and dissolved under an inert atmosphere; and (c) the pH of this solution, if less than 4, is adjusted to 4 to 6 by the addition of an alkali.
Claim 12
Dependent Claim
131 words
A process for the preparation of a solution of a cuprous complex characterised in that (a) a cupric halide is dissolved in a solvent consisting of one or more of ethyl alcohol or a liquid primary alcohol containing 3 or more carbon atoms, polypropylene glycol, propylene glycol, polyethylene glycol, ethylene glycol or other liquid glycol, glycerol.or other liquid triol, an aliphatic betaine and a sulpho-betaine the concentration of Cu being not less than 0.01% w/v of said solution; (b) ascorbic acid not less than 90% of the weight of the Cu present or the equivalent weight of a non-toxic ascorbate, is added and dissolved under an inert atmosphere; and (c) the pH of this solution, if less than 4, is adjusted to 4 to 6 by the addition of an alkali.
Claim 13
Dependent Claim
20 words
A process as claimed in Claim 1 wherein the cupric halide is dissolved at a temperature between 60°C and 80°C.
Claim 14
Dependent Claim
60 words
A process as claimed in Claim 1 or 2 wherein the cupric halide is CuC1 2 .2H 2 0, the non-toxic ascorbate is sodium ascorbate, the weight of ascorbic acid is 100% of the weight of the Cu present or the weight of sodium ascorbate is 112.5% of the weight of the Cu present, and the inert atmosphere is nitrogen.
Claim 15
Dependent Claim
37 words
A process as claimed in any preceding claim wherein the solvent is an aliphatic betaine having a pH between 3.5 and 6.0, a sulpho-betaine having a pH between 3.5 and 6.0 or a mixture of the two.
Claim 16
Dependent Claim
19 words
A process as claimed in any preceding claim, wherein the solution is additionally diluted with a pharmaceutically acceptable diluent.
Claim 17
Independent Claim
33 words
A method of therapeutic treatment of a plant afflicted with a disability caused by a fungus, characterised by topical application of a solution produced by a process as claimed in any preceding claim.
References Cited (Backward Citations)
FR2377393A1
Cited
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