Patent US5162102A successfully refreshed from Google Patents.
US5162102A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Medical instrument and production thereof
Assignee: Terumo Corp
•
Filing: 1988-09-16
•
Granted: 1992-11-10
•
Expires: 2008-09-16
Abstract
Abstract A medical instrument having a blood contact portion formed of a hydrophobic material, wherein a surface-active agent safe to a human body is deposited onto part or the entirety of the blood contact portion so that the medical instrument is fully primed by introducing liquid into the instrument without leaving fine bubbles adhered to the surface of the blood contact portion. Further, a method for fabricating a medical instrument is provided, comprising steps of assembling a medical instrument having a blood contact portion formed of a hydrophobic material, and contacting a liquid containing a surface-active agent safe to a human body to the blood contact portion, followed by drying, leaving the surface-active agent deposited onto the surface of the blood contact portion so that the surface-active agent is steadily and readily deposited onto the blood contact portion of hydrophobic material.
Inventors
- 👤 Atsuhiko Nogawa
- 👤 Osamu Nomura
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 22:05
CPC Classifications
B; B01; B01D; B01D67/00; B01D67/0081; B01D67/0088; A; A61; A61L; A61L33/00; A61L33/0005; A61L33/0011; A61L33/0017; A61M; A61M1/00; A61M1/14; A61M1/16; A61M1/1698; A61M1/36; A61M1/3621; A61M1/3623; B01D63/00; B01D63/02; B01D63/021; B01D63/0233; B01D65/00; B01D65/10; B01D65/104; A61M2207/00; Y; Y10; Y10S; Y10S128/00; Y10S128/03; Y10S261/00; Y10S261/28
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
45 words
A medical instrument comprising a blood contact portion formed of a hydrophobic material and having a non-toxic, nonionic surface-active agent deposited onto said blood contact portion, wherein said surface-active agent is a polyether consisting essentially of a block copolymer of propylene oxide and ethylene oxide.
Claim 2
Dependent Claim
45 words
A medical instrument comprising a blood contact portion formed of a hydrophobic material and having a non-toxic, nonionic surface-active agent deposited onto said blood contact portion, wherein said surface-active agent is a polyether consisting essentially of a block copolymer of propylene oxide and ethylene oxide.
Claim 3
Dependent Claim
37 words
The medical instrument according to claim 1, wherein said medical instrument comprises a membrane oxygenator having a hydrophobic gas-exchange membrane and wherein said nonionic surface-active agent is deposited onto a blood contact portion within said membrane oxygenator.
Claim 4
Dependent Claim
16 words
The medical instrument according to claim 2, wherein said hydrophobic gas-exchange membrane comprises a porous membrane.
Claim 5
Dependent Claim
18 words
The medical instrument according to claim 2, wherein said hydrophobic gas-exchange membrane comprises a porous hollow fiber membrane.
Claim 6
Dependent Claim
124 words
The medical instrument according to claim 2, wherein said membrane oxygenator comprises: a housing having a blood inlet and a blood outlet; a hollow fiber membrane bundle comprising a plurality of gas-exchange hollow fiber membranes provided in said housing; a pair of partitions, said partitions liquid-tightly securing opposite ends of said hollow fiber bundle to said housing; a blood chamber defined by said partitions, an inside surface of said housing, and an outside surface of said hollow fiber membranes; a gas chamber defined in the interior of said hollow fiber membranes; a gas flowpath-defining member disposed outside at least one of the partitions and having a gas inlet in communication with said gas chamber; and a gas outlet means communicating with said gas chamber.
Claim 7
Dependent Claim
36 words
The medical instrument according to claim 1, wherein said medical instrument comprises a blood filter having a hydrophobic membrane and wherein said nonionic surface-active agent is deposited onto a blood contact portion within said blood filter.
Claim 8
Dependent Claim
17 words
The medical instrument according to claim 1, wherein said surface-active agent is dissolved in a priming liquid.
Claim 9
Dependent Claim
21 words
The medical instrument according to claim 1, wherein said surface-active agent has a molecular weight from about 1,000 to several 10,000.
Claim 10
Dependent Claim
27 words
The medical instrument as described in claim 8, wherein said surface-active agent has the following structural formula: HO(C.sub.2 H.sub.4 O).sub.a (C.sub.3 H.sub.6 O).sub.b (C.sub.2 H.sub.4 O).sub.c H.
Claim 11
Dependent Claim
16 words
The medical instrument according to claim 8, wherein said surface-active agent has the following formula: ##STR3##
Claim 12
Dependent Claim
31 words
The medical instrument according to claim 8, wherein said surface-active agent is a polyether which consists of a block copolymer of propylene oxide and ethylene oxide and having terminal hydroxyl groups.
Claim 13
Independent Claim
75 words
A method for fabricating a medical instrument comprising the steps of: assembling a medical instrument having a blood contact portion formed of a hydrophobic material; contacting a liquid containing a non-toxic, nonionic surface-active agent to said blood contact portion, said surface-active agent being a polyether consisting essentially of a block copolymer of propylene oxide and ethylene oxide; and drying said surface-active agent to deposit said surface-active agent onto a surface of said blood contact portion.
Claim 14
Independent Claim
75 words
A method for fabricating a medical instrument comprising the steps of: assembling a medical instrument having a blood contact portion formed of a hydrophobic material; contacting a liquid containing a non-toxic, nonionic surface-active agent to said blood contact portion, said surface-active agent being a polyether consisting essentially of a block copolymer of propylene oxide and ethylene oxide; and drying said surface-active agent to deposit said surface-active agent onto a surface of said blood contact portion.
Claim 15
Dependent Claim
88 words
The method for fabricating a medical instrument according to claim 12, wherein said medical instrument comprises a membrane oxygenator comprising a housing having an interior which is divided into a blood chamber and a gas chamber by a hydrophobic gas-exchange membrane disposed in the housing, said method comprises the steps of assembling said membrane oxygenator, charging said blood chamber with a solution having a surface-active agent added thereto, maintaining a positive pressure differential between the blood chamber and the gas chamber, removing said solution, and drying said solution.
Claim 16
Dependent Claim
19 words
The method for fabricating a medical instrument according to claim 13, wherein said gas-exchange membrane comprises a porous membrane.
Claim 17
Dependent Claim
120 words
The method for fabricating a medical instrument according to claim 13, wherein said membrane oxygenator comprises: a housing; a hollow fiber membrane bundle comprising a plurality of gas-exchange hollow fiber membranes provided in said housing; a pair of partitions, said partitions liquid-tightly securing opposite ends of said hollow fiber bundle to said housing; a blood chamber defined by said partitions, an inside surface of said housing, and an outside surface of said hollow fiber membranes; a gas chamber defined in the interior of said hollow fiber membranes; a gas flowpath-defining member disposed outside at least one of the partitions and having a gas inlet in communication with said gas chamber; and a gas outlet means communicating with said gas chamber.
Claim 18
Dependent Claim
21 words
The method for fabricating a medical instrument according to claim 12, wherein said surface-active agent is dissolved in a priming liquid.
Claim 19
Dependent Claim
25 words
The method for fabricating a medical instrument according to claim 12, wherein said surface-active agent has a molecular weight from about 1,000 to several 10,000.
Claim 20
Dependent Claim
30 words
The method for fabricating a medical instrument according to claim 17, wherein said surface-active agent has the following structural formula: HO(C.sub.2 H.sub.4 O).sub.a (C.sub.3 H.sub.6 O).sub.b (C.sub.2 H.sub.4 O).sub.c H.
Claim 21
Dependent Claim
20 words
The method for fabricating a medical instrument according to claim 17, wherein said surface-active agent has the following formula: ##STR4##
Claim 22
Dependent Claim
35 words
The method for fabricating a medical instrument according to claim 17, wherein said surface-active agent is a polyether which consists of a block copolymer of propylene oxide and ethylene oxide and having terminal hydroxyl groups.
References Cited (Backward Citations)
FR2238680A1
Cited
GB1426668A
Cited
US4239729A
Cited
GB2072206A
Cited
JPS56168750A
Cited
US4374802A
Cited
US4657743A
Cited
GB2117780A
Cited
JPS6096259A
Cited
WO1986002087A1
Cited
US4872867A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-11-10 | 1996-05-11 | 1996-11-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-11-10 | 2000-05-11 | 2000-11-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-11-10 | 2004-05-11 | 2004-11-10 | $7700.00 | Window Closed / Lapsed |