Composition for inducing and stimulating hair growth and retarding its loss, based on nicotinic esters and pyrimidine derivatives

Claim 1

A composition for inducing and stimulating hair growth and retarding its loss, comprising, in a cosmetically or pharmaceutically acceptable medium, an effective amount of at least one pyrimidine derivative corresponding to the formula: ##STR4## or addition salts of the pyrimidine derivative of formula (I) with cosmetically or pharmaceutically acceptable acids, and an effective amount of at least one C 1 -C 6 linear or branched alkylaryl or tetrahydrofurfuryl nicotinic ester, wherein: R 1 denotes a group ##STR5## R 3 and R 4 are selected from the group consisting of hydrogen, C 1 -C 4 alkyl, C 2 -C 5 alkenyl, C 1 -C 4 alkylaryl and lower cycloalkyl group, the alkyl part of which is a C 1 -C 4 alkyl radical, or R 3 and R 4 together form a heterocyclic ring with the nitrogen atom to which they are attached, this heterocyclic ring being selected from the group consisting of aziridinyl, azetidinyl, pyrrolidinyl, piperidino, hexahydroazepinyl, heptamethyleneimino, octamethyleneimino, morpholino and 4-(lower alkyl)piperazidinyl, the heterocyclic groups being unsubstituted or substituted on the carbon atoms with one to three C 1 -C 4 alkyl, hydroxyl or C 1 -C 4 alkoxy; R 2 is selected from the group consisting of hydrogen, C 1 -C 4 alkyl, C 2 -C 5 alkenyl, C 1 -C 4 alkoxy, C 1 -C 4 alkyl, cycloalkyl, C 1 -C 4 aryl, C 1 -C 4 alkylaryl, aryl C 1 -C 4 alkyl, C 1 -C 4 alkylaryl C 1 -C 4 alkyl, C 1 -C 4 alkoxyaryl C 1 -C 4 alkyl and haloaryl C 1 -C 4 alkyl; the concentration of said pyrimidine derivatives or addition salts thereof is between 0.05 and 6% by weight relative to the total weight of the composition; the concentration of said nicotinic esters is between 0.05 and 1% by weight relative to the total weight of the composition; and said effective amounts are effective for inducing and stimulating hair growth and retarding its loss.