US5153174A — Polymer mixtures useful in skin care

Claim 1

Independent Claim 103 words

An aqueous composition consisting essentially of water and a tertiary polymer mixture of components selected from each of the following groups: (1) albumin; (2) a polynucleotide or a polycarboxylate having a molecular weight of at least about 100,000; and (3) a polysulfate or a polysulfonate containing acidic groups with a pK a of less than about 3 in an amount sufficient to provide an equivalent weight of such acidic groups of less than about 1,000; said components being present in amounts sufficient to cause a decrease in light transmission through an aqueous solution of the mixture under acidic as compared to neutral conditions.

Claim 2

Dependent Claim 103 words

An aqueous composition consisting essentially of water and a tertiary polymer mixture of components selected from each of the following groups: (1) albumin; (2) a polynucleotide or a polycarboxylate having a molecular weight of at least about 100,000; and (3) a polysulfate or a polysulfonate containing acidic groups with a pK a of less than about 3 in an amount sufficient to provide an equivalent weight of such acidic groups of less than about 1,000; said components being present in amounts sufficient to cause a decrease in light transmission through an aqueous solution of the mixture under acidic as compared to neutral conditions.

Claim 3

Dependent Claim 47 words

The compositions of claim 1 wherein: (1) the albumin is serum albumin; (2) the polycarboxylate is hyaluronan or derivatives thereof which contain a repeating disaccharide structure of D-glucuronic acid and 2-acetamido-2-desoxy-D-glucose joined by alternating β1-3 glucoronidic and β1-4 glucosaminidic bonds; and (3) the polysulfate is dextran sulfate.

Claim 4

Dependent Claim 30 words

The composition of claim 1 wherein said components are present in amounts effective to cause an increase in the turbidity of the composition under acidic as compared to neutral conditions.

Claim 5

Dependent Claim 33 words

The composition of claim 1 wherein said components are present in amounts effective to cause an additional phase to form when the pH of the composition is changed from neutral to acidic conditions.

Claim 6

Dependent Claim 43 words

The composition of claim 1 wherein said components are present in amounts effective to cause an increase in the light absorbance of the composition of at least 0.1 at 540 nanometers when the pH of the composition is reduced from 7.0 to 5.2.

Claim 7

Dependent Claim 104 words

A skin care composition consisting essentially of a carrier and a ternary polymer mixture of components selected from each of the following groups: (1) albumin; (2) a polycarboxylate having a molecular weight of at least about 100,000; and (3) a polysulfate, a polysulfonate or a polynucleotide containing acidic groups with a pK a of less than about 3 in an amount sufficient to provide an equivalent weight of such acidic groups of less than about 1,000; said components being present in amounts sufficient to cause a decrease in light transmission through an aqueous solution of the mixture under acidic as compared to neutral conditions.

Claim 8

Dependent Claim 104 words

A skin care composition consisting essentially of a carrier and a ternary polymer mixture of components selected from each of the following groups: (1) albumin; (2) a polycarboxylate having a molecular weight of at least about 100,000; and (3) a polysulfate, a polysulfonate or a polynucleotide containing acidic groups with a pK a of less than about 3 in an amount sufficient to provide an equivalent weight of such acidic groups of less than about 1,000; said components being present in amounts sufficient to cause a decrease in light transmission through an aqueous solution of the mixture under acidic as compared to neutral conditions.

Claim 9

Dependent Claim 21 words

The composition of claim 6 wherein the carrier is selected from water, water-in-oil emulsions, oil-in-water emulsions, alcohols, glycols or combinations thereof.

Claim 10

Dependent Claim 12 words

The composition of claim 6 which further comprises a skin care additive.

Claim 11

Dependent Claim 25 words

The composition of claim 6 wherein the polysulfate, polysulfonate or polynucleotide of group (3) has an anionic charge density of from about 100 to 500.

Claim 12

Dependent Claim 27 words

The composition of claim 6 wherein the weight ratio of the albumin of group (1) to the polycarboxylate of group (2) is from about 0.05:1 to 100:1.

Claim 13

Dependent Claim 30 words

The composition of claim 6 wherein the weight ratio of the albumin of group (1) to the polysulfate, polysulfonate or polynucleotide of group (3) is from about 1:1 to 200:1.

Claim 14

Dependent Claim 30 words

The composition of claim 6 wherein the weight ratio of the polysulfate, polysulfonate or polynucleotide of group (3) to the polycarboxylate of group (2) is from about 0.1:1 to 100:1.

Claim 15

Dependent Claim 113 words

A process for diminishing the appearance of wrinkles of the skin which comprises applying to the skin a composition consisting essentially of a carrier and a ternary polymer mixture of components selected from each of the following groups: (1) albumin; (2) a polycarboxylate having a molecular weight of at least about 100,000; and (3) a polysulfate, a polysulfonate or a polynucleotide containing acidic groups with a pK a of less than about 3 in an amount sufficient to provide an equivalent weight of such acidic groups of less than about 1,000; said components being present in amounts sufficient to cause an increase in the turbidity of the composition when applied to the skin.

Claim 16

Dependent Claim 113 words

A process for diminishing the appearance of wrinkles of the skin which comprises applying to the skin a composition consisting essentially of a carrier and a ternary polymer mixture of components selected from each of the following groups: (1) albumin; (2) a polycarboxylate having a molecular weight of at least about 100,000; and (3) a polysulfate, a polysulfonate or a polynucleotide containing acidic groups with a pK a of less than about 3 in an amount sufficient to provide an equivalent weight of such acidic groups of less than about 1,000; said components being present in amounts sufficient to cause an increase in the turbidity of the composition when applied to the skin.

Claim 17

Dependent Claim 47 words

The process of claim 13 wherein: (1) the albumin is serum albumin; (2) the polycarboxylate is hyaluronan or derivatives thereof which contain a repeating disaccharide structure of D-glucuronic acid and 2-acetamido-2-desoxy-D-glucose joined by alternating β1-3 glucoronidic and β1-4 glucosaminidic bonds; and (3) the polysulfate is dextran sulfate.

Annuity Stage	Window Opens	Payment Deadline	Surcharge Period Until	Estimated Fee	Status
3.5 Years (Year 4)	1995-10-06	1996-04-06	1996-10-06	$2000.00	Window Closed / Lapsed
7.5 Years (Year 8)	1999-10-06	2000-04-06	2000-10-06	$3760.00	Window Closed / Lapsed
11.5 Years (Year 12)	2003-10-06	2004-04-06	2004-10-06	$7700.00	Window Closed / Lapsed

Polymer mixtures useful in skin care

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