US5152979A
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US
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Method for treating vascular obstructions caused by abnormal cells
Assignee: Emory University
•
Filing: 1991-08-14
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Granted: 1992-10-06
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Expires: 2011-08-14
Abstract
Abstract In accordance with the present invention, a method is provided for treating ischemia resulting from microvascular compromise caused by abnormal cells in the blood stream, which is often a complication of malaria and leukemia. The method is especially useful for treating cerebral malaria. The method comprises administering to an animal or human with the microvascular compromise a therapeutically effective amount of a surface active copolymer with the following general formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O) b H wherein a is an integer such that the hydrophobe represented by (C 3 H 6 O) has a molecular weight of approximately 950 to 4000 daltons, preferably about 1200 to 3500 daltons, and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) constitutes approximately 50% to 90% by weight of the copolymer.
Inventors
- 👤 Robert L. Hunter
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 07:28
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/74; A61K31/765; A61K31/77; A61K38/00; A61K38/16; A61K38/164; A61K38/166; A61K38/43; A61K38/44; A61K38/446; A61K38/46; A61K38/48; A61K38/49; A61P; A61P33/00; A61P33/02; A61P7/00; A61P7/02; A61P9/00; Y; Y02; Y02A; Y02A50/00; Y02A50/30
Claims Analysis
Total Claims: 27
Claim 1
Independent Claim
110 words
A method for treating vascular obstructions caused by abnormal cells in a human or animal comprising the step of injecting into the human or animal with the vascular obstructions a solution with an effective concentration of a surface active copolymer with the following general formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein a is an integer such that the hydrophobe represented by (C 3 H 6 O) has a molecular weight of between approximately 950 to 4000 daltons, and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) constitutes between approximately 50% to 90% by weight of the copolymer.
Claim 2
Independent Claim
110 words
A method for treating vascular obstructions caused by abnormal cells in a human or animal comprising the step of injecting into the human or animal with the vascular obstructions a solution with an effective concentration of a surface active copolymer with the following general formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein a is an integer such that the hydrophobe represented by (C 3 H 6 O) has a molecular weight of between approximately 950 to 4000 daltons, and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) constitutes between approximately 50% to 90% by weight of the copolymer.
Claim 3
Dependent Claim
79 words
The method of claim 1, wherein the surface active copolymer has the following formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein a is an integer such that the hydrophobe represented by (C 3 H 6 O) has a molecular weight of between approximately 1200 to 3500 daltons, and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) constitutes between approximately 50% to 90% by weight of the copolymer.
Claim 4
Dependent Claim
52 words
The method of claim 1, wherein the surface active copolymer has the following formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein the molecular weight of the hydrophobe (C 3 H 6 O) is approximately 1750 daltons and the total molecular weight of the compound is approximately 8400 daltons.
Claim 5
Independent Claim
111 words
A method for treating vascular obstructions caused by abnormal cells in a human or animal comprising the step of injecting intravenously into the human or animal with the vascular obstructions a solution with an effective concentration of a surface active copolymer with the following general formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein a is an integer such that the hydrophobe represented by (C 3 H 6 O) has a molecular weight of between approximately 950 to 4000 daltons, and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) constitutes between approximately 50% to 90% by weight of the copolymer.
Claim 6
Independent Claim
111 words
A method for treating vascular obstructions caused by abnormal cells in a human or animal comprising the step of injecting intravenously into the human or animal with the vascular obstructions a solution with an effective concentration of a surface active copolymer with the following general formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein a is an integer such that the hydrophobe represented by (C 3 H 6 O) has a molecular weight of between approximately 950 to 4000 daltons, and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) constitutes between approximately 50% to 90% by weight of the copolymer.
Claim 7
Dependent Claim
79 words
The method of claim 4, wherein the surface active copolymer has the following formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein a is an integer such that the hydrophobe represented by (C 3 H 6 O) has a molecular weight of between approximately 1200 to 3500 daltons, and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) constitutes between approximately 50% to 90% by weight of the copolymer.
Claim 8
Dependent Claim
52 words
The method of claim 4, wherein the surface active copolymer has the following formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein the molecular weight of the hydrophobe (C 3 H 6 O) is approximately 1750 daltons and the total molecular weight of the compound is approximately 8400 daltons.
Claim 9
Independent Claim
110 words
A method for treating vascular obstructions caused by abnormal cells in a human or animal comprising the step of injecting intramuscularly into the human or animal with the vascular obstructions a solution with an effective concentration of a surface active copolymer with the following formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein a is an integer such that the hydrophobe represented by (C 3 H 6 O) has a molecular weight of between approximately 950 to 4000 daltons, and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) constitutes between approximately 50% to 90% by weight of the copolymer.
Claim 10
Independent Claim
110 words
A method for treating vascular obstructions caused by abnormal cells in a human or animal comprising the step of injecting intramuscularly into the human or animal with the vascular obstructions a solution with an effective concentration of a surface active copolymer with the following formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein a is an integer such that the hydrophobe represented by (C 3 H 6 O) has a molecular weight of between approximately 950 to 4000 daltons, and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) constitutes between approximately 50% to 90% by weight of the copolymer.
Claim 11
Dependent Claim
79 words
The method of claim 7, wherein the surface active copolymer has the following formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein a is an integer such that the hydrophobe represented by (C 3 H 6 O) has a molecular weight of between approximately 1200 to 3500 daltons, and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) constitutes between approximately 50% to 90% by weight of the copolymer.
Claim 12
Dependent Claim
52 words
The method of claim 7, wherein the surface active copolymer has the following formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein the molecular weight of the hydrophobe (C 3 H 6 O) is approximately 1750 daltons and the total molecular weight of the compound is approximately 8400 daltons.
Claim 13
Independent Claim
103 words
A method for treating malaria in a human or animal comprising the step of injecting into the human or animal with malaria a solution with an effective concentration of a surface active copolymer with the following general formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein a is an integer such that the hydrophobe represented by (C 3 H 6 O) has a molecular weight of between approximately 950 to 4000 daltons, and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) constitutes between approximately 50% to 90% by weight of the copolymer.
Claim 14
Independent Claim
103 words
A method for treating malaria in a human or animal comprising the step of injecting into the human or animal with malaria a solution with an effective concentration of a surface active copolymer with the following general formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein a is an integer such that the hydrophobe represented by (C 3 H 6 O) has a molecular weight of between approximately 950 to 4000 daltons, and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) constitutes between approximately 50% to 90% by weight of the copolymer.
Claim 15
Dependent Claim
79 words
The method of claim 10, wherein the surface active copolymer has the following formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein a is an integer such that the hydrophobe represented by (C 3 H 6 O) has a molecular weight of between approximately 1200 to 3500 daltons, and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) constitutes between approximately 50% to 90% by weight of the copolymer.
Claim 16
Dependent Claim
52 words
The method of claim 10, wherein the surface active copolymer has the following formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein the molecular weight of the hydrophobe (C 3 H 6 O) is approximately 1750 daltons and the total molecular weight of the compound is approximately 8400 daltons.
Claim 17
Dependent Claim
11 words
The method of claim 10, wherein the malaria is cerebral malaria.
Claim 18
Independent Claim
104 words
A method for treating malaria in a human or animal comprising the step of injecting intravenously into the human or animal with malaria a solution with an effective concentration of a surface active copolymer with the following general formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein a is an integer such that the hydrophobe represented by (C 3 H 6 O) has a molecular weight of between approximately 950 to 4000 daltons, and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) constitutes between approximately 50% to 90% by weight of the copolymer.
Claim 19
Independent Claim
104 words
A method for treating malaria in a human or animal comprising the step of injecting intravenously into the human or animal with malaria a solution with an effective concentration of a surface active copolymer with the following general formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein a is an integer such that the hydrophobe represented by (C 3 H 6 O) has a molecular weight of between approximately 950 to 4000 daltons, and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) constitutes between approximately 50% to 90% by weight of the copolymer.
Claim 20
Dependent Claim
79 words
The method of claim 14, wherein the surface active copolymer has the following formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein a is an integer such that the hydrophobe represented by (C 3 H 6 O) has a molecular weight of between approximately 1200 to 3500 daltons, and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) constitutes between approximately 50% to 90% by weight of the copolymer.
Claim 21
Dependent Claim
52 words
The method of claim 14, wherein the surface active copolymer has the following formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein the molecular weight of the hydrophobe (C 3 H 6 O) is approximately 1750 daltons and the total molecular weight of the compound is approximately 8400 daltons.
Claim 22
Dependent Claim
11 words
The method of claim 14, wherein the malaria is cerebral malaria.
Claim 23
Independent Claim
103 words
A method for treating malaria in a human or animal comprising the step of injecting intramuscularly into the human or animal with malaria a solution with an effective concentration of a surface active copolymer with the following formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein a is an integer such that the hydrophobe represented by (C 3 H 6 O) has a molecular weight of between approximately 950 to 4000 daltons, and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) constitutes between approximately 50% to 90% by weight of the copolymer.
Claim 24
Independent Claim
103 words
A method for treating malaria in a human or animal comprising the step of injecting intramuscularly into the human or animal with malaria a solution with an effective concentration of a surface active copolymer with the following formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein a is an integer such that the hydrophobe represented by (C 3 H 6 O) has a molecular weight of between approximately 950 to 4000 daltons, and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) constitutes between approximately 50% to 90% by weight of the copolymer.
Claim 25
Dependent Claim
79 words
The method of claim 18, wherein the surface active copolymer has the following formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein a is an integer such that the hydrophobe represented by (C 3 H 6 O) has a molecular weight of between approximately 1200 to 3500 daltons, and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) constitutes between approximately 50% to 90% by weight of the copolymer.
Claim 26
Dependent Claim
52 words
The method of claim 18, wherein the surface active copolymer has the following formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein the molecular weight of the hydrophobe (C 3 H 6 O) is approximately 1750 daltons and the total molecular weight of the compound is approximately 8400 daltons.
Claim 27
Dependent Claim
11 words
The method of claim 18, wherein the malaria is cerebral malaria.
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