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US5152781A Expired / Lapsed US ⏱️ 0.0 years remaining

Medical devices fabricated from homopolymers and copolymers having recurring carbonate units

Assignee: United States Surgical Corp
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Filing: 1992-02-10
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Granted: 1992-10-06
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Expires: 2012-02-10
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Abstract

Abstract This invention relates to medical devices formed totally or in part from homopolymers or copolymers comprising recurring carbonate moieties.

Inventors

  • 👤 Reginald T. Tang
  • 👤 Frank Mares
  • 👤 William J. Boyle, Jr.
  • 👤 Tin-Ho Chiu
  • 👤 Kundanbhai M. Patel

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-23 16:51
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/14; A61L27/18; A61L15/00; A61L15/16; A61L15/42; A61L15/64; A61L17/00; A61L17/06; A61L17/10; A61L31/00; A61L31/04; A61L31/06

Claims Analysis

Total Claims: 41
Claim 1
Independent Claim 343 words
A medical device for use within a living animal in contact with the tissue or body fluids of said animal, said device comprising a body having one or more surfaces adapted to contact said tissue, said fluid or a combination of said tissue and said fluid, said surfaces formed totally or in part of one or more biopolymers selected from the group consisting of homopolymers or random copolymers having at least one type of recurring monomeric unit of the following General Structure I or II: ##STR14## wherein: Z is [C(R 5 R 6 )], [NR 5 ], --O-- or a combination thereof, where Z is selected such that there are no adjacent heteroatoms; n is from 1 to about 8; m is from 1 to about 8; R 1 , R 2 , R 3 , and R 4 are the same or different at each occurrence and are hydrogen, aryloxyalkyl, alkyoxyarly, aryloxyarly, arylalkyl, alkylarlyalkyl, arylalkylaryl, alkylaryl, arylcarbonyalkyl, alkyl, aryl, alkylcarbonyalkyl, cycloalkyl, arylcarbonylaryl, alkylcarbonylarly, alkoxyalkyl, or aryl or alkyl substituted with one or more substitutents selected from the group consisting of alkyl, aryl, alkoxy, aryloxy, dialkylamino, diarylamino, and alkylarylamino; and R 5 and R 6 are the same or different and are R 1 , R 2 , R 3 , R 4 , dialkylamino, diarylamino, alkylarylamino, alkoxy, aryloxy, alkanoyl, or arylcarbonyl, or any two of R 1 to R 6 together may form an alkylene chain completing a 3, 4, 5, 6, 7, 8 or 9 membered alicyclic fused, spiro, bicyclic or tricyclic ring system or a combination thereof, which system may optionally include one or more non-adjacent carbonyl, oxa, alkylaza or arylaza groups; with the proviso that when said biopolymers and copolymer having recurring units of the Structure I derived from trimethylene carbonate, the other recurring monomeric units of the copolymer are not derived from glycolide or glycolic acid and with the further proviso that when the said biopolymers are homopolymers having recurring units of the Structure II derived from ethylene carbonate or propylene carbonate then m is other than 1.
Claim 2
Dependent Claim 343 words
A medical device for use within a living animal in contact with the tissue or body fluids of said animal, said device comprising a body having one or more surfaces adapted to contact said tissue, said fluid or a combination of said tissue and said fluid, said surfaces formed totally or in part of one or more biopolymers selected from the group consisting of homopolymers or random copolymers having at least one type of recurring monomeric unit of the following General Structure I or II: ##STR14## wherein: Z is [C(R 5 R 6 )], [NR 5 ], --O-- or a combination thereof, where Z is selected such that there are no adjacent heteroatoms; n is from 1 to about 8; m is from 1 to about 8; R 1 , R 2 , R 3 , and R 4 are the same or different at each occurrence and are hydrogen, aryloxyalkyl, alkyoxyarly, aryloxyarly, arylalkyl, alkylarlyalkyl, arylalkylaryl, alkylaryl, arylcarbonyalkyl, alkyl, aryl, alkylcarbonyalkyl, cycloalkyl, arylcarbonylaryl, alkylcarbonylarly, alkoxyalkyl, or aryl or alkyl substituted with one or more substitutents selected from the group consisting of alkyl, aryl, alkoxy, aryloxy, dialkylamino, diarylamino, and alkylarylamino; and R 5 and R 6 are the same or different and are R 1 , R 2 , R 3 , R 4 , dialkylamino, diarylamino, alkylarylamino, alkoxy, aryloxy, alkanoyl, or arylcarbonyl, or any two of R 1 to R 6 together may form an alkylene chain completing a 3, 4, 5, 6, 7, 8 or 9 membered alicyclic fused, spiro, bicyclic or tricyclic ring system or a combination thereof, which system may optionally include one or more non-adjacent carbonyl, oxa, alkylaza or arylaza groups; with the proviso that when said biopolymers and copolymer having recurring units of the Structure I derived from trimethylene carbonate, the other recurring monomeric units of the copolymer are not derived from glycolide or glycolic acid and with the further proviso that when the said biopolymers are homopolymers having recurring units of the Structure II derived from ethylene carbonate or propylene carbonate then m is other than 1.
Claim 3
Dependent Claim 62 words
The device of claim 1 wherein R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are the same or different and are selected from the group consisting of hydrogen, alkyl, cycloalkyl, alkylaryl, alkoxyalkyl, aryloxyalkyl, aryloxyaryl, aryl and arylalkyl groups, and aryl, arylalkyl or alkylaryl substituted with one or more alkyl, alkoxy and alkoxyalkyl groups.
Claim 4
Dependent Claim 57 words
The device of claim 2 wherein R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are the same or different and are selected from the groups consisting of hydrogen, alkyl, cycloalkyl, alkylphenyl, alkoxyalkyl and phenylalkyl, and phenyl, alkylphenyl and phenylalkyl substituted with one or more alkyl or alkoxy groups.
Claim 5
Dependent Claim 63 words
The device of claim 3 wherein: Z is --O-- or a combination thereof; n is 1, 2, or 3; m is 1, 2, 3, 4, 5 or 6; and R 1 to R 6 are selected from the group consisting of substitutents in which aliphatic moieties include up to about 10 carbon atoms and aryl moieties include up to about 16 carbon atoms.
Claim 6
Dependent Claim 98 words
The device of claim 1 wherein said biopolymers comprises at least one type of recurring monomeric units of the following general Structure II or III: wherein: n is 1 to about 3; m is 1 to about 4; R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are the same or different and are hydrogen, aryl, alkylaryl, arylalkyl or alkyl, or R 5 and R 6 together may form an aliphatic chain having from about 3 to about 10 membered spiro, bicylcic, or tricyclic ring structure or a combination thereof.
Claim 7
Dependent Claim 48 words
The device of claim 5 wherein: n is 1, 2 or 3; m is 1, 2 or 3; and R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are the same or different and are hydrogen, alkyl, phenylalkyl or alkylphenyl.
Claim 8
Dependent Claim 41 words
The device of claim 6 wherein R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are the same or different and are hydrogen or alkyl having from 1 to about 7 carbon atoms.
Claim 9
Dependent Claim 117 words
The device of claim 1 wherein the biopolymers comprises at least one type of recurring monomeric unit moieties selected from the group consisting of: ##STR15## wherein: R 5 and R 6 are the same or different and are hydrogen, alkyl, aryl, cycloalkyl, arylalkyl, alkoxyalkyl, aryloxyalkyl, or aryl or arylalkyl substituted with one or more alkyl or alkoxy groups alkoxy, alkanoyl, dialkylamino, or R 5 or R 6 together may form an alkylene chain completing a 4, 5, 6, 7, 8, 9 or 10 membered spiro, bicyclic, or tricyclic ring structure or a combination thereof, which structure may optionally include one or more non-adjacent divalent carbonyl, oxa, alkylaza or arylaza groups; and n is 1, 2 or 3.
Claim 10
Dependent Claim 43 words
The device of claim 8 wherein R 5 and R 6 are the same or different and are phenyl, hydrogen, phenylalkyl, alkylphenyl, alkyl, or R 5 and R 6 together form alkylene a divalent chain forming a 4 to 8 membered ring structure.
Claim 11
Dependent Claim 27 words
The device of claim 9 wherein R 5 and R 6 together form a 5 to 7 membered spiro, or bicyclic ring structure or a combination thereof.
Claim 12
Dependent Claim 24 words
The device of claim 9 wherein R 5 and R 6 are the same or different and are hydrogen, alkyl, phenyl, alkylphenyl or phenylalkyl.
Claim 13
Dependent Claim 13 words
The device of claim 8 wherein R 5 and R 6 are hydrogen.
Claim 14
Dependent Claim 23 words
The device of claim 11 wherein R 5 and R 6 are hydrogen or alkyl of from about 1 to 4 carbon atoms.
Claim 15
Dependent Claim 20 words
The device of claim 13 wherein R 5 and R 6 are alkyl of about 1 to 4 carbon atoms.
Claim 16
Dependent Claim 11 words
The device of claim 13 wherein said biopolymer is a homopolymer.
Claim 17
Dependent Claim 42 words
The device of claim 1 wherein the wt % of recurring monomeric units of the Structure I or Structure II included in said copolymer is at least about 50 wt % based on the total wt of monomeric units in the copolymer.
Claim 18
Dependent Claim 20 words
The device of claim 16 wherein said wt % is from about 80 wt % to about 100 wt %.
Claim 19
Dependent Claim 18 words
The device of claim 17 wherein said wt % is from about 85 to about 100 wt %.
Claim 20
Dependent Claim 18 words
The device of claim 18 wherein said wt % is from about 85 to about 99 wt %.
Claim 21
Dependent Claim 12 words
The device of claim 14 wherein said copolymer is a random copolymer.
Claim 22
Dependent Claim 65 words
The device of claim 1 wherein said biopolymers are selected from the group consisting of random copolymers comprising at least one type of recurring unit of the General Structures I and II, and at least other type of recurring monomeric units derived from the group consisting of substituted carbonates, non-substituted carbonates, lactones, dioxepanones, dioxanones other than carbonates, epoxides, epoxide/CO 2 , anhydrides, orthoesters, and orthocarbonates.
Claim 23
Dependent Claim 36 words
The device of claim 20 wherein said copolymer comprises recurring monomeric units derived from 2, 2-dimethyltrimethylene carbonate and other types of recurring monomeric units derived from orthocarbonates, orthoesters, lactones, trimethylene carbonates, ethylene carbonates and tetramethylene carbonates.
Claim 24
Dependent Claim 26 words
The device of claim 20 wherein said copolymer comprises recurring monomeric units derived from trimethylene carbonate and other types of recurring monomeric units derived from lactones.
Claim 25
Dependent Claim 31 words
The device of claim 15 or 20 which is a totally or partially bioresorbable medical device suitable for implantation in side of a living system to promote regeneration of body tissue.
Claim 26
Dependent Claim 12 words
The device of claim 15 or 20 which is a nerve channel.
Claim 27
Dependent Claim 17 words
The device of claim 15 or 20 which is a vascular device for vascular regeneration or growth.
Claim 28
Dependent Claim 18 words
The device of claim 15 or 20 which is an orthopedica device for bone repair or fracture fixation.
Claim 29
Dependent Claim 16 words
The device of claim 15 or 20 which is a wound covering or wound closure device.
Claim 30
Dependent Claim 14 words
The device of claim 15 or 20 for tendon or ligament regeneration or repair.
Claim 31
Dependent Claim 13 words
The device of claim 15 or 20 which further comprises a biodurable portion.
Claim 32
Dependent Claim 23 words
The device of claim 20 wherein said biopolymers are selected from the group consisting of poly(trimethylene carbonate-co-lactide), poly(dimethyltrimethylene carbonate-co-trimethylene carbonate) and poly(dimethyltrimethylene carbonate-co-caprolactone).
Claim 33
Dependent Claim 17 words
The device of claim 31 wherein said device is formed totally or in part from poly(trimethylene carbonate-co-lactide).
Claim 34
Dependent Claim 18 words
The device of claim 31 wherein said device is formed totally or in part from poly(dimethyltrimethylene carbonate-co-trimethylene carbonate).
Claim 35
Dependent Claim 31 words
The device of claim 32 wherein the weight ratio of dimethyltrimethylene carbonate to trimethylene carbonate in said poly(dimethyltrimethylene carbonate-co-trimethylene carbonate) is from about 25 to 75 to about 97:5 to 2.5.
Claim 36
Dependent Claim 20 words
The device of claim 34 wherein said weight ration is from about 56 to 44 to about 97:5 to 2.5.
Claim 37
Dependent Claim 20 words
The device of claim 35 wherein said weight ratio is from about 79 to 21 to about 97.5 to 2.5.
Claim 38
Dependent Claim 20 words
The device of claim 36 wherein said weight ratio is from about 95 to 5 to about 97.5 to 2.5.
Claim 39
Dependent Claim 17 words
The device of claim 31 wherein said device is formed totally or in part from poly(dimethyltrimethylene carbonate-co-caprolactone).
Claim 40
Dependent Claim 11 words
The device of claim 15 or 20 which is a suture.
Claim 41
Dependent Claim 60 words
The device of claim 15 or 20 for delivery of drugs in a living animal wherein said body is fabricated totally or in part from totally or partially bioresorbable biopolymers and wherein said drugs are inside of said body, and said drugs are delivered to said body in the desired amount as said bioresorbable biopolymers in said body are bioresorbed.

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