Patent US5141847A successfully refreshed from Google Patents.
US5141847A
Expired / Lapsed
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Method and apparatus for producing pulsation
Assignee: Kureha Corp
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Filing: 1990-02-20
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Granted: 1992-08-25
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Expires: 2010-02-20
Abstract
Abstract In an apparatus which applies periodic pulsation to a solution flowing through a conduit while undergoing perfusion by a pump, a first valve is disposed in the conduit downstream of the pump, a bypass line is provided to the conduit downstream of the first valve, and a second valve is disposed in the bypass line for withdrawing some of a first pulsed flow formed in the conduit by opening and closing the first valve, through the bypass line as a second pulsed flow. A valve driving circuit periodically opens and closes the first valve and second valve at predetermined time schedules so that the second pulsed flow is superimposed upon the first pulsed flow to form a waveform in the conduit. Any desired pulsatile waveform can be obtained by adjusting the pulse width, the crest values, the delay time, etc., of the two pulsed flows.
Inventors
- 👤 Keizo Sugimachi
- 👤 Kenji Takenaka
- 👤 Mitsuo Shimada
- 👤 Kengo Fukuzawa
- 👤 Takashi Nishizaki
- 👤 Tetsuo Ikeda
- 👤 Atsushi Yoshihara
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 19:10
CPC Classifications
A; A61; A61M; A61M1/00; A61M1/36; A61M1/3621; A01; A01N; A01N1/00; A01N1/10; A01N1/14; A01N1/142; A01N1/143; A61M60/00; A61M60/10; A61M60/104; A61M60/109; A61M60/113; A61M60/20; A61M60/205; A61M60/216; A61M60/226; A61M60/232; A61M60/247; A61M60/253; A61M60/268; A61M60/279; A61M60/30; A61M60/36; A61M60/38; A61M60/50; A61M60/508; A61M60/538; A61M60/554; A61M60/562; A61M1/14; A61M1/16; A61M1/1698; A61M1/3623; A61M2205/00; A61M2205/33; A61M2205/3331; A61M2205/3337; Y; Y10; Y10T; Y10T137/00; Y10T137/8593; Y10T137/86389; Y10T137/86405; Y10T137/86421
Claims Analysis
Total Claims: 24
Claim 1
Independent Claim
106 words
A method of providing a predetermined pulsed flow of a solution to an organ, comprising the steps of: pumping the solution through a perfusion line connected to the organ; periodically restricting the flow of the solution in the perfusion line to provide a first pulsed flow of the solution in the perfusion line; and withdrawing some of the solution in the first pulsed flow thereof from the perfusion line through a bypass line and periodically restricting the flow of the solution in the bypass line in synchronism with the changing of the flow in the perfusion line to provide the predetermined pulsed flow to the organ.
Claim 2
Independent Claim
106 words
A method of providing a predetermined pulsed flow of a solution to an organ, comprising the steps of: pumping the solution through a perfusion line connected to the organ; periodically restricting the flow of the solution in the perfusion line to provide a first pulsed flow of the solution in the perfusion line; and withdrawing some of the solution in the first pulsed flow thereof from the perfusion line through a bypass line and periodically restricting the flow of the solution in the bypass line in synchronism with the changing of the flow in the perfusion line to provide the predetermined pulsed flow to the organ.
Claim 3
Dependent Claim
29 words
The method of claim 1 wherein the perfusion line and the bypass line are opened and closed to periodically restrict the flow of the solution in the respective lines.
Claim 4
Dependent Claim
29 words
The method of claim 2 wherein the bypass line is opened and closed at different times than the opening and closing of the perfusion line and in synchronism therewith.
Claim 5
Dependent Claim
18 words
The method of claim 1, further comprising the step of oxygenating the solution upstream of the pump means.
Claim 6
Dependent Claim
24 words
The method of claim 4, further comprising the step of applying suction of a prescribed pressure to the solution withdrawn through the bypass line.
Claim 7
Dependent Claim
19 words
The method of claim 4, wherein the solution is maintained at a temperature between 3° C. and 10° C.
Claim 8
Dependent Claim
22 words
The method of claim 1, further comprising the step of maintaining the solution at a temperature between 3° C. and 10° C.
Claim 9
Dependent Claim
24 words
The method of claim 1, further comprising the step of applying suction of a prescribed pressure to the solution withdrawn through the bypass line.
Claim 10
Independent Claim
199 words
An apparatus which provides a predetermined pulsed flow of a solution to an organ, comprising: a conduit arrangement having an inlet and an outlet adapted to be connected to said organ to thereby enable said solution to be pumped to said organ; pump means connected to direct said solution from said inlet to said outlet through said conduit arrangement; first valve means disposed in said conduit arrangement downstream of said pump means; a bypass line connected between a first portion of said conduit arrangement downstream of said first valve means and a second portion of said conduit arrangement upstream of said pump means; second valve means disposed in said bypass line; valve controlling means for periodically operating said first valve means sand said second valve means in synchronism to provide a first pulsed flow of said solution in said first portion of said conduit arrangement upstream of said bypass line and said predetermined pulsed flow in said first portion of said conduit arrangement downstream of said connection of said first portion of said conduit arrangement to said bypass line, said apparatus further comprising an oxygenator disposed in said conduit arrangement upstream of said pump means and first valve means.
Claim 11
Independent Claim
199 words
An apparatus which provides a predetermined pulsed flow of a solution to an organ, comprising: a conduit arrangement having an inlet and an outlet adapted to be connected to said organ to thereby enable said solution to be pumped to said organ; pump means connected to direct said solution from said inlet to said outlet through said conduit arrangement; first valve means disposed in said conduit arrangement downstream of said pump means; a bypass line connected between a first portion of said conduit arrangement downstream of said first valve means and a second portion of said conduit arrangement upstream of said pump means; second valve means disposed in said bypass line; valve controlling means for periodically operating said first valve means sand said second valve means in synchronism to provide a first pulsed flow of said solution in said first portion of said conduit arrangement upstream of said bypass line and said predetermined pulsed flow in said first portion of said conduit arrangement downstream of said connection of said first portion of said conduit arrangement to said bypass line, said apparatus further comprising an oxygenator disposed in said conduit arrangement upstream of said pump means and first valve means.
Claim 12
Dependent Claim
37 words
The apparatus of claim 9, further comprising pressure control means for controlling pressure of said solution upstream of said first valve means and pressure of said solution downstream of said second valve means within respective prescribed limits.
Claim 13
Dependent Claim
24 words
The apparatus of claim 10 wherein said pressure control means comprises means for applying suction to said solution downstream of said second valve means.
Claim 14
Dependent Claim
35 words
The apparatus of claim 9 wherein said valve controlling means comprises means for opening and closing said first and second valve means to thereby open and close said conduit arrangement and said bypass line, respectively.
Claim 15
Dependent Claim
48 words
The apparatus of claim 12 wherein said valve controlling means comprises means for opening and closing said second valve means at different times than said valve controlling means opens and closes said first valve means but in synchronism with the opening and closing of said first valve means.
Claim 16
Dependent Claim
12 words
The apparatus of claim 9 wherein said oxygenator is a membrane-type oxygenator.
Claim 17
Dependent Claim
13 words
The apparatus of claim 9 wherein said pump means comprises a roller-type pump.
Claim 18
Dependent Claim
21 words
The apparatus of claim 9 wherein said first valve means and said second valve means each comprises a solenoid pinch valve.
Claim 19
Dependent Claim
57 words
The apparatus of claim 9, further comprising an air-tight chamber for containing said organ, said chamber being connected to said inlet and said outlet of said conduit arrangement, whereby an artery side of said organ may be connected to said conduit arrangement and a vein side of said organ may communicate with the interior of said chamber.
Claim 20
Dependent Claim
13 words
The apparatus of claim 9 wherein said pump means comprises a centrifugal pump.
Claim 21
Dependent Claim
13 words
The apparatus of claim 9 wherein said pump means comprises a diaphragm pump.
Claim 22
Dependent Claim
20 words
The apparatus of claim 9 wherein said first valve means and said second valve means each comprises an electromagnetic valve.
Claim 23
Dependent Claim
23 words
The apparatus of claim 9 wherein said first valve means and said second valve means each comprises a valve driven by pneumatic pressure.
Claim 24
Dependent Claim
23 words
The apparatus of claim 9 wherein said first valve means and said second valve means each comprises a valve driven by hydraulic pressure.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-08-25 | 1996-02-24 | 1996-08-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-08-25 | 2000-02-24 | 2000-08-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-08-25 | 2004-02-24 | 2004-08-25 | $7700.00 | Window Closed / Lapsed |