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US4473637A Expired / Lapsed US ⏱️ 0.0 years remaining

System for processing an organ preparatory to transplant

Assignee: Guibert Colman and Associates
•
Filing: 1982-11-10
•
Granted: 1984-09-25
•
Expires: 2002-11-10
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Abstract

Abstract A system for processing an organ such as a kidney so as to render it suitable for storage, shipment and eventual transplantation. After its removal from a donor, the organ is cradled in a net suspended within a basin. A preservative fluid initially at normal blood temperatures progressively cooled to avoid thermal shock, the fluid being pumped through the organ to flush out its natural fluids. The pumping action is such as to simulate that of the heart and its associated circulatory system. The exterior of the organ is chilled by simultaneously introducing the preservative fluid into the basin. After this chilling procedure is completed, the cradle carrying the cooled organ is transferred to a basin disposed in a thermally-insulated shipping box which is then filled with chilled preservative fluid and maintained at a desired low temperature level by an associated refrigeration unit. Just prior to transplantation, the cradle carrying the organ is removed from the box and the organ is again flushed, using the same procedure as in chilling but in reverse, the preservative fluid being raised to a temperature level close to normal blood temperature. Upon completion of this procedure, the organ is in condition for transplantation.

Inventors

  • 👤 Raul Guibert

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-24 04:39
CPC Classifications
A; A01; A01N; A01N1/00; A01N1/10; A01N1/14; A01N1/142; A01N1/143

Claims Analysis

Total Claims: 8
Claim 1
Independent Claim 113 words
Apparatus for maintaining an organ removed from the body of a donor in a healthy state for subsequent transplantation, said apparatus comprising means to flush the removed organ by pumping a preservative fluid through the vascular system thereof in a pulsatory stream for a predetermined period in a manner simulating the activity of the heart and its associated circulatory system, and means including a heater and a refrigerator operative during said period to progressively reduce the temperature of said preservative fluid from an initial level close to that of normal blood temperature to a temperature approaching the freezing point to avoid subjecting the organ to an abrupt thermal shock damaging to its condition.
Claim 2
Dependent Claim 113 words
Apparatus for maintaining an organ removed from the body of a donor in a healthy state for subsequent transplantation, said apparatus comprising means to flush the removed organ by pumping a preservative fluid through the vascular system thereof in a pulsatory stream for a predetermined period in a manner simulating the activity of the heart and its associated circulatory system, and means including a heater and a refrigerator operative during said period to progressively reduce the temperature of said preservative fluid from an initial level close to that of normal blood temperature to a temperature approaching the freezing point to avoid subjecting the organ to an abrupt thermal shock damaging to its condition.
Claim 3
Dependent Claim 45 words
Apparatus as set forth in claim 1, wherein said means to flush the organ includes a pump producing periodic pulses of the preservative fluid which are supplied to an expansible bellows caused by each pulse to expand, the bellows collapsing in the interval between pulses.
Claim 4
Dependent Claim 58 words
Apparatus as set forth in claim 1, further including: A. means to concurrently subject the exterior of the organ to said preservative fluid; and B. means to progressively reduce the temperature of the preservative fluid to which the exterior of the organ is exposed to cause the organ to assume a substantially uniform low-temperature above its freezing point.
Claim 5
Dependent Claim 61 words
Apparatus as set forth in claim 3, wherein said means to reduce the temperature of the preservative fluid is constituted by a timed motor-driven rotary cam which engages a flexible line conducting a liquid agent for chilling the fluid, said cam in the course of a full revolution progressively increasing the flow of the refrigerant in the course of the period.
Claim 6
Dependent Claim 32 words
Apparatus as set forth in claim 4, wherein said fluid is contained in a bottle surrounded by a heat exchange coil through which said refrigerant from said line is caused to flow.
Claim 7
Dependent Claim 21 words
Apparatus as set forth in claim 3 wherein said organ being treated is held in a net suspended within a basin.
Claim 8
Dependent Claim 39 words
Apparatus as set forth in claim 6, wherein said organ is a kidney and means to admit said preservative fluid into the renal artery of the kidney and means to discharge the fluid from the renal vein and urethra.

References Cited (Backward Citations)

US3406531A Cited
US3607646A Cited
US3632473A Cited
US3892628A Cited
US3810367A Cited
US3914954A Cited
US3777507A Cited
US3881990A Cited
US4186565A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1987-09-25 1988-03-26 1988-09-25 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1991-09-25 1992-03-26 1992-09-25 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1995-09-25 1996-03-26 1996-09-25 $7700.00 Window Closed / Lapsed

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