US5139768A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Dental composition for hypersensitive teeth
Assignee: Yissum Research Development Co of Hebrew University of Jerusalem
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Filing: 1991-02-28
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Granted: 1992-08-18
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Expires: 2011-02-28
Abstract
Abstract The invention relates to an oral composition for the treatment and prevention of dental hypersensitivity comprising an anti-hypersensitivity agent embedded in a sustained release carrier such as a cellulosic or hydrophobic polymer, and a method for the use of said composition in treating and preventing dental hypersensitivity. The invention also provides for the supplementation of said oral composition with an adhesive and a plasticizer to increase the effectiveness of the anti-hypersensitivity agent.
Inventors
- 👤 Michael Friedman
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 14:27
CPC Classifications
A; A61; A61K; A61K6/00; A61K6/60; A61K6/69; A61K6/20
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
142 words
A sustained-release dental hypersensitivity preventative varnish composition which comprises: (a) an agent capable of suppressing dental hypersensitivity, wherein said agent is selected from the group consisting of strontium salt, potassium, lithium or sodium nitrate, potassium bicarbonate, potassium chloride, hydroxyapatite, fluorapatite, ammonium oxalate, EDTA with flouride, flouride, and ammonium glycyrrhizzinate; (b) a sustained release hydrophobic polymer, wherein said polymer is selected from the group consisting of polyethylene, polyamide-nylon, poly(ethylene-vinyl acetate), cellulose nitrate and silicones; and (c) a plasticizer; in a pharmaceutically acceptable vehicle, wherein said vehicle is selected from the group consisting of water, ethyl alcohol, and ethyl alcohol mixed with water, wherein said composition is capable of forming a film which adheres to a dental surface, and wherein said film which adheres to a dental surface is capable of providing efficacious levels of said agent for the treatment of said dental hypersensitivity.
Claim 2
Dependent Claim
142 words
A sustained-release dental hypersensitivity preventative varnish composition which comprises: (a) an agent capable of suppressing dental hypersensitivity, wherein said agent is selected from the group consisting of strontium salt, potassium, lithium or sodium nitrate, potassium bicarbonate, potassium chloride, hydroxyapatite, fluorapatite, ammonium oxalate, EDTA with flouride, flouride, and ammonium glycyrrhizzinate; (b) a sustained release hydrophobic polymer, wherein said polymer is selected from the group consisting of polyethylene, polyamide-nylon, poly(ethylene-vinyl acetate), cellulose nitrate and silicones; and (c) a plasticizer; in a pharmaceutically acceptable vehicle, wherein said vehicle is selected from the group consisting of water, ethyl alcohol, and ethyl alcohol mixed with water, wherein said composition is capable of forming a film which adheres to a dental surface, and wherein said film which adheres to a dental surface is capable of providing efficacious levels of said agent for the treatment of said dental hypersensitivity.
Claim 3
Dependent Claim
25 words
A method of prevention of dental hypersensitivity comprising application of the varnish composition of claim 1 to the teeth or gingival tissues of an animal.
Claim 4
Dependent Claim
17 words
The varnish composition of claim 1 wherein said agent capable of suppressing dental hypersensitivity is strontium salt.
Claim 5
Dependent Claim
11 words
The method of claim 2, wherein said application is by brush.
Claim 6
Dependent Claim
11 words
The method of claim 2, wherein said application is by spray.
Claim 7
Dependent Claim
11 words
The method of claim 2, wherein said animal is a human.
Claim 8
Dependent Claim
26 words
The varnish composition of claim 1, which additionally contains an agent selected from the group consisting of a flavoring agent, surface active agent and coloring agent.
Claim 9
Dependent Claim
12 words
The method of claim 2, wherein said animal is a domesticated animal.
Claim 10
Dependent Claim
23 words
The varnish composition of claim 1, wherein said plasticizer is selected from the group consisting of polyethylene glycol, glycerol, sorbitol, and mineral oil.
Claim 11
Dependent Claim
12 words
The varnish composition of claim 1, which additionally contains an adhesive gum.
Claim 12
Dependent Claim
13 words
The varnish composition of claim 10, wherein said adhesive gum is gum mastic.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-08-18 | 1996-02-17 | 1996-08-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-08-18 | 2000-02-17 | 2000-08-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-08-18 | 2004-02-17 | 2004-08-18 | $7700.00 | Window Closed / Lapsed |