US5137906A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Treatment of central nervous system disorders with benzimidazole angiotensin-II receptor antagonists
Assignee: EIDP Inc
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Filing: 1990-03-20
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Granted: 1992-08-11
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Expires: 2010-03-20
Abstract
Abstract Substituted benzimidazoles such as 2-butyl-1-[(2'-carboxybiphenyl-4-yl)methyl]-6-chlorobenzimidazole and pharmaceutically acceptable salts thereof are useful for treating central nervous system disorders, such as cognitive and learning disorders, mediated by angiotensin II.
Inventors
- 👤 Andrew T. Chiu
- 👤 Victor J. De Noble
- 👤 John J. V. Duncia
- 👤 Pancras C. B. Wong
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 03:11
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/41; A61K31/415; A61K31/535; C; C07; C07D; C07D235/00; C07D235/02; C07D235/04; C07D235/06; C07D235/08; C07D235/12
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
148 words
A method of treating impaired cognitive performance which comprises administering to a patient in need of such treatment an effective amount of a compound of formula (I): ##STR6## or a pharmaceutically suitable salt thereof, where: R 1 is --CO 2 H, --NHSO 2 CF 3 , or ##STR7## R 2 is H R 3 is alkyl of 3 to 5 carbon atoms, alkenyl or alkynyl of 3 to 5 carbon atoms each of which may be optionally substituted with OH, OCH 3 , CO 2 H or CO 2 CH 3 ; A is Cl; OCH 3 ; (CH 2 ) n OH; (CH 2 ) n OCOCH 3 ; CHO; CO 2 H; or (CH 2 ) n COR 5 ; B is H R 5 is H, OH, CH 3 , OCH 3 or ##STR8## n is 1-2 x is a carbon-carbon single bond, or --NHCO--.
Claim 2
Independent Claim
148 words
A method of treating impaired cognitive performance which comprises administering to a patient in need of such treatment an effective amount of a compound of formula (I): ##STR6## or a pharmaceutically suitable salt thereof, where: R 1 is --CO 2 H, --NHSO 2 CF 3 , or ##STR7## R 2 is H R 3 is alkyl of 3 to 5 carbon atoms, alkenyl or alkynyl of 3 to 5 carbon atoms each of which may be optionally substituted with OH, OCH 3 , CO 2 H or CO 2 CH 3 ; A is Cl; OCH 3 ; (CH 2 ) n OH; (CH 2 ) n OCOCH 3 ; CHO; CO 2 H; or (CH 2 ) n COR 5 ; B is H R 5 is H, OH, CH 3 , OCH 3 or ##STR8## n is 1-2 x is a carbon-carbon single bond, or --NHCO--.
Claim 3
Dependent Claim
18 words
Method of claim 1 wherein the compound of formula (I) is 2-butyl-1-[(2'-carboxybiphenyl-4-yl)methyl]-6-hydroxymethyl-benzimidazole or a pharmaceutically suitable salt thereof.
Claim 4
Dependent Claim
18 words
Method of claim 1 wherein the compound of formula (I) is 2-butyl-1-[(2'-carboxybiphenyl-4-yl)methyl]-5-hydroxymethyl-benzimidazole or a pharmaceutically suitable salt thereof.
Claim 5
Dependent Claim
18 words
Method of claim 1 wherein the compound of formula (I) is 2-butyl-1[(2'-carboxybiphenyl-4-yl)methyl]-6-methoxybenzimidazole or a pharmaceutically suitable salt thereof.
Claim 6
Dependent Claim
18 words
Method of claim 1 wherein the compound of formula (I) is 2-butenyl-1-[(2'-carboxybiphenyl-4-yl)methyl]-6-hydroxymethyl-benzimidazole or a pharmaceutically suitable salt thereof.
Claim 7
Dependent Claim
18 words
Method of claim 1 wherein the compound of formula (I) is 2-butyl-1-[(2'-carboxybiphenyl-4-yl)methyl]-6-chlorobenzimidazole or a pharmaceutically suitable salt thereof.
References Cited (Backward Citations)
US4301169A
Cited
US4402966A
Cited
US4533669A
Cited
US4602031A
Cited
US4812462A
Cited
EP0288907A2
Cited
EP0307872A2
Cited
US4880804A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-08-11 | 1996-02-10 | 1996-08-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-08-11 | 2000-02-10 | 2000-08-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-08-11 | 2004-02-10 | 2004-08-11 | $7700.00 | Window Closed / Lapsed |