US4402966A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Acylaminophenyl imidazoles and anti-depressing agent containing the same
Assignee: Eisai Co Ltd
•
Filing: 1981-04-09
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Granted: 1983-09-06
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Expires: 2001-04-09
Abstract
Abstract An imidazole compound of the formula: ##STR1## wherein R 1 is lower alkyl, R 2 is hydrogen or lower alkyl, and R 3 , R 4 and R 5 are hydrogen, lower alkyl, trifluoromethyl, amino, mono- or di-lower alkylamino, heterocyclic amino, halogen or ##STR2## (in which R 6 is hydrogen, lower alkyl or lower alkylsulfonyl, A is carbonyl or sulfonyl, and R 7 is lower alkyl, halogenated lower alkyl, mono- or di-lower alkylamino, mono- or di-lower alkylaminoalkyl, unsubstituted phenyl or phenyl having halogen, lower alkyl, lower alkoxy or trifluoromethyl, phenylamino or phenylamino having halogen, lower alkyl, lower alkoxy or trifluoromethyl); and their pharmaceutically acceptable acid addition salts. The compounds are useful for treating patients suffering from depression.
Inventors
- 👤 Motosuke Yamanaka
- 👤 Isao Saito
- 👤 Kiyomi Yamatsu
- 👤 Takako Fujimoto
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 03:29
CPC Classifications
C; C07; C07D; C07D233/00; C07D233/54; C07D233/64; A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/41; A61K31/415; A61K31/435; A61K31/44; A61K31/445; C07D231/00; C07D231/02; C07D231/10; C07D231/12; C07D233/56; C07D249/00; C07D249/02; C07D249/08
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
75 words
A compound having the formula ##STR275## in which R 1 is lower alkyl; R 2 is hydrogen or lower alkyl; R 6 is hydrogen, lower alkyl or lower alkylsulfonyl; R 7 is lower alkyl, halogenated lower alkyl, mono- or di-lower alkylamino, mono- or di-lower alkylminoalkyl, phenyl, phenyl substituted with halogen, lower alkyl, lower alkoxy or trifluoromethyl, phenylamino, phenylamino substituted with halogen, lower alkyl, lower alkoxy or trifluoromethyl; or a pharmaceutically acceptable acid addition salt thereof.
Claim 2
Dependent Claim
75 words
A compound having the formula ##STR275## in which R 1 is lower alkyl; R 2 is hydrogen or lower alkyl; R 6 is hydrogen, lower alkyl or lower alkylsulfonyl; R 7 is lower alkyl, halogenated lower alkyl, mono- or di-lower alkylamino, mono- or di-lower alkylminoalkyl, phenyl, phenyl substituted with halogen, lower alkyl, lower alkoxy or trifluoromethyl, phenylamino, phenylamino substituted with halogen, lower alkyl, lower alkoxy or trifluoromethyl; or a pharmaceutically acceptable acid addition salt thereof.
Claim 3
Dependent Claim
27 words
A compound as claimed in claim 1 in which R 6 is hydrogen and R 7 is phenyl substituted with halogen, lower alkyl, lower alkoxy or trifluoromethyl.
Claim 4
Dependent Claim
75 words
A compound having the formula ##STR276## in which R 1 is lower alkyl; R 2 is hydrogen or lower alkyl; R 6 is hydrogen, lower alkyl or lower alkylsulfonyl; R 7 is lower alkyl, halogenated lower alkyl, mono- or di-lower alkylamino, mono- or di-lower alkylaminoalkyl, phenyl, phenyl substituted with halogen, lower alkyl, lower alkoxy or trifluoromethyl, phenylamino, phenylamino substituted with halogen, lower alkyl, lower alkoxy or trifluoromethyl; or a pharmaceutically acceptable acid addition salt thereof.
Claim 5
Dependent Claim
75 words
A compound having the formula ##STR276## in which R 1 is lower alkyl; R 2 is hydrogen or lower alkyl; R 6 is hydrogen, lower alkyl or lower alkylsulfonyl; R 7 is lower alkyl, halogenated lower alkyl, mono- or di-lower alkylamino, mono- or di-lower alkylaminoalkyl, phenyl, phenyl substituted with halogen, lower alkyl, lower alkoxy or trifluoromethyl, phenylamino, phenylamino substituted with halogen, lower alkyl, lower alkoxy or trifluoromethyl; or a pharmaceutically acceptable acid addition salt thereof.
Claim 6
Dependent Claim
27 words
A compound as claimed in claim 3 in which R 6 is hydrogen and R 7 is phenyl substituted with halogen, lower alkyl, lower alkoxy or trifluoromethyl.
Claim 7
Dependent Claim
17 words
A compound as defined in claim 1 which is 1-[4-(4-chlorobenzoylamino)phenyl]-2-methylimidazole; and pharmaceutically acceptable acid addition salts thereof.
Claim 8
Dependent Claim
17 words
A compound as defined in claim 1 which is 1-[4-(4-fluorobenzoylamino)phenyl]-2-methylimidazole; and pharmaceutically acceptable acid addition salts thereof.
Claim 9
Dependent Claim
17 words
A compound as defined in claim 1 which is 1-[4-(4-chlorobenzoylamino)phenyl]-2-ethylimidazole; and pharmaceutically acceptable acid addition salts thereof.
Claim 10
Dependent Claim
17 words
A compound as defined in claim 1 which is 1-[4-(4-methylbenzoylamino)phenyl]-2-ethylimidazole; and pharmaceutically acceptable acid addition salts thereof.
Claim 11
Dependent Claim
17 words
A compound as defined in claim 1 which is 1-[4-(4-chlorobenzoylamino)phenyl]-2-isopropylimidazole; and pharmaceutically acceptable acid addition salts thereof.
Claim 12
Dependent Claim
17 words
A compound as defined in claim 1 which is 1-[4-(4-methylbenzoylamino)phenyl]-2-methylimidazole; and pharmaceutically acceptable acid addition salts thereof.
Claim 13
Dependent Claim
29 words
A pharmaceutical composition for treating depression and depressive states, comprising a therapeutically effective amount of a compound as claimed in claim 1 or claim 3, and a pharmaceutical carrier.
References Cited (Backward Citations)
US4172947A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-09-05 | 1987-03-07 | 1987-09-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-09-05 | 1991-03-07 | 1991-09-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-09-05 | 1995-03-07 | 1995-09-06 | $7700.00 | Window Closed / Lapsed |