US4301169A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Novel imidazole compound and anti-depressing agent containing the same
Assignee: Eisai Co Ltd
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Filing: 1979-11-13
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Granted: 1981-11-17
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Expires: 1999-11-13
Abstract
Abstract An imidazole compound of the formula: ##STR1## wherein R 1 is lower alkyl, R 2 is hydrogen or lower alkyl, and R 3 , R 4 and R 5 are hydrogen, lower alkyl, trifluoromethyl, amino, mono- or di-lower alkylamino, heterocyclic amino, halogen or ##STR2## (in which R 6 is hydrogen, lower alkyl or lower alkylsulfonyl, A is carbonyl or sulfonyl, and R 7 is lower alkyl, halogenated lower alkyl, mono- or di-lower alkylamino, mono- or di-lower alkylaminoalkyl, unsubstituted phenyl or phenyl having halogen, lower alkyl, lower alkoxy or trifluoromethyl, phenylamino or phenylamino having halogen, lower alkyl, lower alkoxy or trifluoromethyl); and their pharmaceutically acceptable acid addition salts.
Inventors
- 👤 Motosuke Yamanaka
- 👤 Isao Saito
- 👤 Kiyomi Yamatsu
- 👤 Takako Fujimoto
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 03:03
CPC Classifications
C; C07; C07D; C07D233/00; C07D233/54; C07D233/64; A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/41; A61K31/415; A61K31/435; A61K31/44; A61K31/445; C07D231/00; C07D231/02; C07D231/10; C07D231/12; C07D233/56; C07D249/00; C07D249/02; C07D249/08
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
107 words
A method for treating depression which comprises administering to a patient suffering from depression a pharmaceutical composition comprising a therapeutically effective amount of a compound having the formula ##STR275## in which R 1 is lower alkyl, R 2 is hydrogen or lower alkyl, A is carbonyl or sulfonyl, R 6 is hydrogen, lower alkyl or lower alkylsulfonyl, R 7 is lower alkyl, halogenated lower alkyl, mono- or di-lower alkylamino, mono- or di-lower alkylaminoalkyl, phenyl, phenyl substituted with halogen, lower alkyl, lower alkoxy or trifluoromethyl, phenylamino, or phenylamino substituted with halogen, lower alkyl, lower alkoxy or trifluoromethyl, and pharmaceutically acceptable acid addition salts thereof, and a pharmaceutical carrier.
Claim 2
Independent Claim
107 words
A method for treating depression which comprises administering to a patient suffering from depression a pharmaceutical composition comprising a therapeutically effective amount of a compound having the formula ##STR275## in which R 1 is lower alkyl, R 2 is hydrogen or lower alkyl, A is carbonyl or sulfonyl, R 6 is hydrogen, lower alkyl or lower alkylsulfonyl, R 7 is lower alkyl, halogenated lower alkyl, mono- or di-lower alkylamino, mono- or di-lower alkylaminoalkyl, phenyl, phenyl substituted with halogen, lower alkyl, lower alkoxy or trifluoromethyl, phenylamino, or phenylamino substituted with halogen, lower alkyl, lower alkoxy or trifluoromethyl, and pharmaceutically acceptable acid addition salts thereof, and a pharmaceutical carrier.
Claim 3
Independent Claim
102 words
A method for treating depression which comprises administering to a patient suffering from depression a pharmaceutical composition comprising a therapeutically effective amount of a compound having the formula ##STR276## in which R 1 is lower alkyl, R 2 is hydrogen or lower alkyl, R 6 is hydrogen, lower alkyl or lower alkylsulfonyl, R 7 is lower alkyl, halogenated lower alkyl, mono- or di-lower alkylamino, mono- or di-lower alkylaminoalkyl, phenyl, phenyl substituted with halogen, lower alkyl, lower alkoxy or trifluoromethyl, phenylamino, or phenylamino substituted with halogen, lower alkyl, lower alkoxy or trifluoromethyl, and pharmaceutically acceptable acid addition salts thereof, and a pharmaceutical carrier.
Claim 4
Independent Claim
102 words
A method for treating depression which comprises administering to a patient suffering from depression a pharmaceutical composition comprising a therapeutically effective amount of a compound having the formula ##STR276## in which R 1 is lower alkyl, R 2 is hydrogen or lower alkyl, R 6 is hydrogen, lower alkyl or lower alkylsulfonyl, R 7 is lower alkyl, halogenated lower alkyl, mono- or di-lower alkylamino, mono- or di-lower alkylaminoalkyl, phenyl, phenyl substituted with halogen, lower alkyl, lower alkoxy or trifluoromethyl, phenylamino, or phenylamino substituted with halogen, lower alkyl, lower alkoxy or trifluoromethyl, and pharmaceutically acceptable acid addition salts thereof, and a pharmaceutical carrier.
Claim 5
Independent Claim
102 words
A method for treating depression which comprises administering to a patient suffering from depression a pharmaceutical composition comprising a therapeutically effective amount of a compound having the formula ##STR277## in which R 1 is lower alkyl, R 2 is hydrogen or lower alkyl, R 6 is hydrogen, lower alkyl or lower alkylsulfonyl, R 7 is lower alkyl, halogenated lower alkyl, mono- of di-lower alkylamino, mono- or di-lower alkylaminoalkyl, phenyl, phenyl substituted with halogen, lower alkyl, lower alkoxy or trifluoromethyl, phenylamino, or phenylamino substituted with halogen, lower alkyl, lower alkoxy or trifluoromethyl, and pharmaceutically acceptable acid addition salts thereof, and a pharmaceutical carrier.
Claim 6
Independent Claim
102 words
A method for treating depression which comprises administering to a patient suffering from depression a pharmaceutical composition comprising a therapeutically effective amount of a compound having the formula ##STR277## in which R 1 is lower alkyl, R 2 is hydrogen or lower alkyl, R 6 is hydrogen, lower alkyl or lower alkylsulfonyl, R 7 is lower alkyl, halogenated lower alkyl, mono- of di-lower alkylamino, mono- or di-lower alkylaminoalkyl, phenyl, phenyl substituted with halogen, lower alkyl, lower alkoxy or trifluoromethyl, phenylamino, or phenylamino substituted with halogen, lower alkyl, lower alkoxy or trifluoromethyl, and pharmaceutically acceptable acid addition salts thereof, and a pharmaceutical carrier.
Claim 7
Dependent Claim
20 words
A method as claimed in claim 2 in which said compound is 1-[4-(4-chlorobenzoylamino)phenyl]-2-methylimidazole; and pharmaceutically acceptable acid addition salts thereof.
Claim 8
Dependent Claim
20 words
A method as claimed in claim 2 in which said compound is 1-[4-(4-fluorobenzoylamino)phenyl]-2-methylimidazole; and pharmaceutically acceptable acid addition salts thereof.
Claim 9
Dependent Claim
20 words
A method as claimed in claim 2 in which said compound is 1-[4-(4-chlorobenzoylamino)phenyl]-2-ethylimidazole; and pharmaceutically acceptable acid addition salts thereof.
Claim 10
Dependent Claim
20 words
A method as claimed in claim 2 in which said compound is 1-[4-(4-methlybenzoylamino)phenyl]-2-ethylimidazole; and pharmaceutically acceptable acid addition salts thereof.
Claim 11
Dependent Claim
20 words
A method as claimed in claim 2 in which said compound is 1-[4-(4-chlorobenzoylamino)phenyl]-2-isopropylimidazole; and pharmaceutically acceptable acid addition salts thereof.
Claim 12
Dependent Claim
20 words
A method as claimed in claim 2 in which said compound is 1-[4-(4-methylbenzoylamino)phenyl]-2-methylimidazole; and pharmaceutically acceptable acid addition salts thereof.
Claim 13
Dependent Claim
27 words
A method as claimed in claim 2 in which R 6 is hydrogen and R 7 is phenyl substituted with halogen, lower alkyl, lower alkoxy or trifluoromethyl.
Claim 14
Dependent Claim
27 words
A method as claimed in claim 3 in which R 6 is hydrogen and R 7 is phenyl substituted with halogen, lower alkyl, lower alkoxy or trifluoromethyl.
References Cited (Backward Citations)
US4172947A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-11-16 | 1985-05-18 | 1985-11-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-11-16 | 1989-05-18 | 1989-11-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-11-16 | 1993-05-18 | 1993-11-17 | $7700.00 | Window Closed / Lapsed |