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Patent US5120656A successfully refreshed from Google Patents.
US5120656A
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Process for debriding bone
Assignee: Warsaw Orthopedic Inc
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Filing: 1990-08-03
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Granted: 1992-06-09
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Expires: 2010-08-03
Abstract
Abstract Bone is enzymatically debrided prior to undergoing further processing which renders the bone suitable for osteoprosthetic use.
Inventors
- 👤 Robert K. O'Leary
- 👤 Annamarie B. Prewett
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 12:20
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/36; A61L27/3604; A61L27/3608; A61F; A61F2/00; A61F2/02; A61F2/28; A61L27/3683; A61L31/00; A61L31/005
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
55 words
A process for the debridement of harvested bone having its periosteum intact which comprises contacting, the periosteum with a solution of at least one collagen-digesting enzyme under enzyme activity-promoting conditions for a period of time sufficient to loosen the periosteum from the underlying bone surface and thereafter removing the enzymatically loosened periosteum from the bone.
Claim 2
Dependent Claim
55 words
A process for the debridement of harvested bone having its periosteum intact which comprises contacting, the periosteum with a solution of at least one collagen-digesting enzyme under enzyme activity-promoting conditions for a period of time sufficient to loosen the periosteum from the underlying bone surface and thereafter removing the enzymatically loosened periosteum from the bone.
Claim 3
Dependent Claim
21 words
The process of claim 1 wherein the collagen-digesting enzyme is selected from the group consisting of collagenase, stromelysin and mixtures thereof.
Claim 4
Dependent Claim
19 words
The process of claim 1 wherein the temperature of contacting ranges from about 20° C. to about 70° C.
Claim 5
Dependent Claim
18 words
The process of claim 1 wherein the temperature of contacting ranges from about 25° to about 55° C.
Claim 6
Dependent Claim
14 words
The process of claim 1 wherein the pH ranges from about 3 to 9.
Claim 7
Dependent Claim
22 words
The process of claim 1 wherein the contact time of the periosteum with the enzyme solution is at least about 30 minutes.
Claim 8
Dependent Claim
15 words
The process of claim 1 wherein the enzyme solution is a sterile physiological saline solution.
Claim 9
Dependent Claim
13 words
The process of claim 1 wherein the enzyme solution contains a permeation enhancer.
Claim 10
Dependent Claim
14 words
The process of claim 8 wherein the permeation enhancer is a surface active agent.
Claim 11
Dependent Claim
22 words
The process of claim 1 wherein the enzyme solution contains at least one member of the group consisting of antibiotic and disinfectant.
Claim 12
Dependent Claim
10 words
The process of claim 10 wherein the disinfectant is ethanol.
Claim 13
Dependent Claim
26 words
The process of claim 1 wherein the enzyme solution contains a permeation enhancer and at least one member of the group consisting of antibiotic and disinfectant.
Claim 14
Dependent Claim
31 words
The process of claim 1 wherein the enzyme solution contains an enzyme permeation enhancing amount of at least one enzyme permeation enhancing surface active agent and a disinfecting amount of ethanol.
Claim 15
Dependent Claim
28 words
The process of claim 1 wherein the enzymatically loosened periosteum is removed from the bone by the impact of a high velocity fluid stream directed against the periosteum.
Claim 16
Dependent Claim
16 words
The process of claim 14 wherein the high velocity fluid stream is water or physiological saline.
Claim 17
Dependent Claim
26 words
The process of claim 1 wherein removal of the enzymatically loosened periosteum from the bone is accompanied by exposure of the bone to sterilizing ultraviolet radiation.
Claim 18
Dependent Claim
41 words
The process of claim 15 wherein removal of the enzymatically loosened periosteum from the bone is accompanied by exposure of the bone to sterilizing ultraviolet radiation directed against the surface of the periosteum upon which the high velocity fluid stream impinges.
Claim 19
Dependent Claim
31 words
The process of claim 1 wherein the periosteum-containing bone is contacted with a solution of proteolytic enzyme before, during or following contact of the periosteum with the solution of collagen-digesting enzyme.
Claim 20
Dependent Claim
17 words
The process of claim 18 wherein the proteolytic enzyme is present in the solution of collagen-digesting enzyme.
Claim 21
Dependent Claim
11 words
The process of claim 18 wherein the collagen-digesting enzyme is collagenase.
Claim 22
Dependent Claim
11 words
The process of claim 19 wherein the collagen-digesting enzyme is collagenase.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-06-09 | 1995-12-09 | 1996-06-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-06-09 | 1999-12-09 | 2000-06-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-06-09 | 2003-12-09 | 2004-06-09 | $7700.00 | Window Closed / Lapsed |