US5116596A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Process for the preparation of an organ-specific substance labeled with technetium-99m
Assignee: CIS Bio International SA
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Filing: 1989-10-27
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Granted: 1992-05-26
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Expires: 2009-10-27
Abstract
Abstract The invention relates to a process for the preparation of an organ-specific substance labeled with technetium-99m, in which an organ-specific substance, or an organ-specific substance which has been pretreated or coupled to a complexing agent for technetium-99m, is mixed with [99m]-pertechnetate and a complex-stabilized reducing agent.
Inventors
- 👤 Karl-Heinz Bremer
- 👤 Ludwig Kuhlmann
- 👤 Alexander Schwarz
- 👤 Axel Steinstrasser
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 05:33
CPC Classifications
A; A61; A61K; A61K51/00; A61K51/02; A61K51/04; A61K51/08; A61K51/12; A61K51/10; A61K51/1045; A61K51/1048; A61K51/1057; A61K2123/00; Y; Y10; Y10S; Y10S530/00; Y10S530/866
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
65 words
A test kit comprising two separate freeze-dried components, one of which contains an organ-specific substance which has been pretreated in order to generate at least one functional group having complexing properties in the molecule of the organ-specific substance, and the other component contains a reducing agent which is required for the reduction of 99m pertechnetate and subsequent binding of technetium-99m to the pretreated organ-specific substance.
Claim 2
Dependent Claim
65 words
A test kit comprising two separate freeze-dried components, one of which contains an organ-specific substance which has been pretreated in order to generate at least one functional group having complexing properties in the molecule of the organ-specific substance, and the other component contains a reducing agent which is required for the reduction of 99m pertechnetate and subsequent binding of technetium-99m to the pretreated organ-specific substance.
Claim 3
Dependent Claim
22 words
A test kit as claimed in claim 1, wherein the organ-specific substance is a partially reduced antibody or its F(ab') 2 fragment.
Claim 4
Dependent Claim
23 words
A test kit as claimed in claim 2, wherein the freeze-dried antibody component is mixed with disodium hydrogen phosphate as a buffer substance.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-05-26 | 1995-11-25 | 1996-05-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-05-26 | 1999-11-25 | 2000-05-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-05-26 | 2003-11-25 | 2004-05-26 | $7700.00 | Window Closed / Lapsed |