EP0035765A2
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EP
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A physiologically active substance-combined compound and its use for the preparation of a radioactive metallic element-labeled compound
Assignee: Nihon Medi Physics Co Ltd
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Filing: 1981-03-06
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Granted: —
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Expires: 2001-03-06
Abstract
Abstract A radioactive diagnostic agent which comprises deferoxamine,.and a physiologically active compound and a radioactive metallic element chemically connected thereto with or without intervention of any other chemical bonding, which is characteristic in having a high stability even after administered into a human body and showing substantially the same behavior in a human body as said physiologically active compound itself.
Inventors
- 👤 Akira Yokoyama
- 👤 Yoshiro C/O Mr. Soichiro Asano Omomo
- 👤 Hisashi Tanaka
- 👤 Hideo C/O Mr. Hiromitsu Kimura Saji
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-26 05:41
CPC Classifications
A; A61; A61K; A61K51/00; A61K51/02; A61K51/04; A61K51/0474; A61K51/0478; A61K2123/00
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
41 words
A radioactive metallic element-labeled, pnysiologically active substance-combined compound, which consists of deferoxamine, a physiologically active substance chemically bonded thereto with or without intervention of any other chemical bonding and a radioactive metallic element bonded to said deferoxamine through a chelating bond.
Claim 2
Dependent Claim
41 words
A radioactive metallic element-labeled, pnysiologically active substance-combined compound, which consists of deferoxamine, a physiologically active substance chemically bonded thereto with or without intervention of any other chemical bonding and a radioactive metallic element bonded to said deferoxamine through a chelating bond.
Claim 3
Dependent Claim
40 words
The compound according to claim 1, wherein the physiologically active substance has a carboxyl group and is bonded to deferoxamine by forming a -CONH- linkage between the carboxyl group in the physiologically active substance and the amino group in deferoxamine.
Claim 4
Dependent Claim
78 words
The compound according to claim I, wherein the physiologically active substance has an amino group and is bonded to deferoxamine with intervention of a compound having at least two carbonyl groups by forming a C=N-linkage between the amino group in the physiologically active substance and an carboxyl group in said compound and also between the amino group in deferoxamine and another carbonyl group in said compound, the C=N- linkage being thereafter converted into a CHNH- linkage by reduction.
Claim 5
Dependent Claim
15 words
The compound according to claim 1, wherein the physiologically active substance is human serum albumin.
Claim 6
Dependent Claim
13 words
The compound according to claim 1, wherein the physiologically active substance is urokinase.
Claim 7
Dependent Claim
13 words
The compound according to claim 1, wherein the physiologically active substance is fibrinogen.
Claim 8
Dependent Claim
13 words
The compound according to claim 1, wherein the radioactive metallic element is Ga.
Claim 9
Dependent Claim
14 words
The compound according to claim 1, wherein the radioactive metallic element is 111 In.
Claim 10
Dependent Claim
26 words
A physiologically active substance-combined compound, which consists of deferoxamine and a physiologically active substance chemically bonded thereto with or' without intervention of any other chemical bonding.
Claim 11
Dependent Claim
26 words
A physiologically active substance-combined compound, which consists of deferoxamine and a physiologically active substance chemically bonded thereto with or' without intervention of any other chemical bonding.
Claim 12
Dependent Claim
40 words
The compound according to claim 9, wherein the physiologically active substance has a carboxyl group and is bonded to deferoxamine by forming a -CONH- linkage between the carboxyl group in the physiologically active substance and the amino group in deferoxamine.
Claim 13
Dependent Claim
78 words
The compound according to claim 9, wherein the physiologically active substance has an amino group and is bonded to deferoxamine with intervention of a compound having at least two carbonyl groups by forming a C=N-linkage between the amino group in the physiologically active substance and an carboxyl group in said compound and also between the amino group in deferoxamine and another carbonyl group in said compound, the C=N- linkage being thereafter converted into a CHNH- linkage by reduction.
References Cited (Backward Citations)
No citation records indexed.
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