Patent US5111221A successfully refreshed from Google Patents.
US5111221A
Expired / Lapsed
US
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Receptor-based sensor
Assignee: United States Department of the Navy
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Filing: 1990-06-27
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Granted: 1992-05-05
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Expires: 2010-06-27
Abstract
Abstract This invention relates to a semiconductor substrate having a porous surfacend to the amperometric receptor-based sensors formed with the substrate. More specifically, this invention pertains to the substrate in the form of a bipolar junction transistor having a porous hydrophilic surface directly on its base wherein the surface forms a support for an amperometric sensor. The invention also pertains to the methods of making and using the substrate and sensor.
Inventors
- 👤 Thomas L. Fare
- 👤 Frances S. Ligler
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 21:35
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/543; G01N33/54366; G01N33/54373; G01N33/5438; G01N27/00; G01N27/26; G01N27/28; G01N27/30; G01N27/327; G01N27/3275; G01N27/3277; B; B01; B01J; B01J2219/00; B01J2219/00274; B01J2219/00718; B01J2219/0072; B01J2219/00734; Y; Y10; Y10S; Y10S438/00; Y10S438/96
Claims Analysis
Total Claims: 30
Claim 1
Independent Claim
64 words
An amperometric sensor comprising: a semiconductor substrate having a nonporous portion and a hydrophilic porous portion on said nonporous portion, and a high impedance receptor film in intimate contact with and sealing at least the porous portion, said receptor film permitting a significant ionic current to enter said porous portion only in response to an interaction of said receptor film with a predetermined chemical.
Claim 2
Dependent Claim
64 words
An amperometric sensor comprising: a semiconductor substrate having a nonporous portion and a hydrophilic porous portion on said nonporous portion, and a high impedance receptor film in intimate contact with and sealing at least the porous portion, said receptor film permitting a significant ionic current to enter said porous portion only in response to an interaction of said receptor film with a predetermined chemical.
Claim 3
Dependent Claim
12 words
A sensor according to claim 1 wherein the semiconductor substrate is silicon.
Claim 4
Dependent Claim
15 words
A sensor according to claim 1 wherein the receptor film is a Langmuir-Blodgett type film.
Claim 5
Dependent Claim
15 words
A sensor according to claim 2 wherein the receptor film is a Langmuir-Blodgett type film.
Claim 6
Dependent Claim
14 words
A sensor according to claim 3 wherein the film is formed from a lipid.
Claim 7
Dependent Claim
14 words
A sensor according to claim 4 wherein the film is formed from a lipid.
Claim 8
Dependent Claim
12 words
A sensor according to claim 6 wherein the film is a bilayer.
Claim 9
Dependent Claim
19 words
A sensor according to claim 2 wherein the semiconductor substrate is in the form of a bipolar junction transistor.
Claim 10
Dependent Claim
15 words
A sensor according to claim 8 wherein the receptor film is a Langmuir-Blodgett type film.
Claim 11
Dependent Claim
14 words
A sensor according to claim 9 wherein the film is formed from a lipid.
Claim 12
Dependent Claim
12 words
A sensor according to claim 10 wherein the film is a bilayer.
Claim 13
Dependent Claim
17 words
The sensor of claim 1, wherein said receptor film comprises a lipid bilayer including a receptor protein.
Claim 14
Dependent Claim
17 words
The sensor of claim 1, wherein the pores of said hydrophilic porous portion form a wormhole network.
Claim 15
Dependent Claim
21 words
The sensor of claim 13, wherein the pores of said hydrophilic porous portion have diameters of from 1 to 1000 nm.
Claim 16
Dependent Claim
19 words
The sensor of claim 14, wherein the pores of said hydrophilic portion have diameters of less than 100 μm.
Claim 17
Dependent Claim
56 words
An amperometric, receptor-based sensor comprising: a semiconductor substrate having a nonporous portion and a hydrophilic porous portion, and a high impedance receptor film covering at least the porous portion, said receptor film permitting a significant ionic current to enter said porous portion only in response to an interaction of said receptor film with a predetermined chemical.
Claim 18
Dependent Claim
56 words
An amperometric, receptor-based sensor comprising: a semiconductor substrate having a nonporous portion and a hydrophilic porous portion, and a high impedance receptor film covering at least the porous portion, said receptor film permitting a significant ionic current to enter said porous portion only in response to an interaction of said receptor film with a predetermined chemical.
Claim 19
Dependent Claim
17 words
The sensor of claim 16, wherein said receptor film comprises a lipid bilayer including a receptor protein.
Claim 20
Dependent Claim
21 words
The sensor of claim 16, wherein the pores of said hydrophilic porous portion have diameters of from 1 to 1000 nm.
Claim 21
Dependent Claim
17 words
The sensor of claim 1, wherein the pores of said hydrophilic porous portion form a wormhole network.
Claim 22
Independent Claim
71 words
A method of making an amperometric receptor-based sensor comprising the steps of: forming a nonporous semiconductor substrate; forming a hydrophilic porous portion on a surface of said nonporous semiconductor substrate; and sealing at least the hydrophilic porous portion with a layer of high-impedance receptor film which permits a significant ionic current to enter the porous portion only in response to the interaction of said receptor film with a chemical of interest.
Claim 23
Independent Claim
71 words
A method of making an amperometric receptor-based sensor comprising the steps of: forming a nonporous semiconductor substrate; forming a hydrophilic porous portion on a surface of said nonporous semiconductor substrate; and sealing at least the hydrophilic porous portion with a layer of high-impedance receptor film which permits a significant ionic current to enter the porous portion only in response to the interaction of said receptor film with a chemical of interest.
Claim 24
Dependent Claim
17 words
The method of claim 20, wherein said receptor film comprises a lipid bilayer including a receptor protein.
Claim 25
Dependent Claim
17 words
The method of claim 20, wherein the pores of said hydrophilic porous portion form a wormhole network.
Claim 26
Dependent Claim
21 words
The method of claim 22, wherein the pores of said hydrophilic porous portion have diameters of from 1 to 1000 nm.
Claim 27
Dependent Claim
19 words
The method of claim 23, wherein the pores of said hydrophilic portion have diameters of less than 100 μm.
Claim 28
Dependent Claim
31 words
The method of claim 20, wherein said hydrophilic porous portion is in intimate contact with said semiconductor substrate and said receptor film is in intimate contact with said hydrophilic porous portion.
Claim 29
Dependent Claim
51 words
The sensor of claim 2, wherein the porous hydrophilic portion is made by a method comprising the step of etching an outer, nonporous silicon layer of said substrate to produce a porous silicon layer and then growing a outer layer of oxide on an outer layer of said porous silicon layer.
Claim 30
Dependent Claim
58 words
The method of claim 20, wherein said nonporous semiconductor substrate is silicon and said hydrophilic porous portion is made by a method comprising the step of etching an outer, nonporous silicon layer of said substrate to produce a porous silicon layer and then growing a outer layer of oxide on an outer layer of said porous silicon layer.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-05-05 | 1995-11-04 | 1996-05-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-05-05 | 1999-11-04 | 2000-05-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-05-05 | 2003-11-04 | 2004-05-05 | $7700.00 | Window Closed / Lapsed |