US4874499A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Electrochemical microsensors and method of making such sensors
Assignee: Massachusetts Institute of Technology
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Filing: 1988-05-23
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Granted: 1989-10-17
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Expires: 2008-05-23
Abstract
Abstract Electrochemical microsensors formed of a substrate containing means for sensing potential or current, including active and passive electronic devices and electronic circuits, and a micromachined structure containing at least one cavity overlying the sensing means, wherein the structure and substrate are bonded together at a temperature less than about 400° C., in the absence of high voltage fields, using means not requiring highly planarized surfaces. A wide variety of materials can be utilized for both the substrate and overlying structure. Diverse embodiments are possible, having in common a cavity containing a chemically sensitive material and means for sensing potential or current. The resulting structural organization of materials transduces a chemical signal, such as concentration, to an electrical signal, which is then "processed" by the underlying FET or metallic connections. The present invention resolves the problems of the prior art in combining sensing devices with chemically sensitive material(s) to form a functional microsensor in a conveniently manufacturable fashion.
Inventors
- 👤 Rosemary L. Smith
- 👤 Scott D. Collins
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 19:53
CPC Classifications
G; G01; G01N; G01N27/00; G01N27/26; G01N27/403; G01N27/414; Y; Y10; Y10T; Y10T156/00; Y10T156/10
Claims Analysis
Total Claims: 43
Claim 1
Independent Claim
128 words
An electrochemical microsensor comprising: a substrate containing microelectronic means for sensing potential or current; a micromachined structure having openings extending into a cavity therein from opposite sides of the structure, wherein said structure has been produced by photolithographic transfer of a two dimensional pattern onto a material to form a three dimensional structure following selective removal of the material; and wherein the structure containing the cavity has been positioned over the substrate so that an opening into the cavity extends over the sensing means and the cavity containing structure has been adhered to the substrate using a process which simultaneously adheres multiple structures to substrates as a single unit, with an adhesive forming a seal between the substrate and structure at a temperature less than approximately 400° C.
Claim 2
Dependent Claim
128 words
An electrochemical microsensor comprising: a substrate containing microelectronic means for sensing potential or current; a micromachined structure having openings extending into a cavity therein from opposite sides of the structure, wherein said structure has been produced by photolithographic transfer of a two dimensional pattern onto a material to form a three dimensional structure following selective removal of the material; and wherein the structure containing the cavity has been positioned over the substrate so that an opening into the cavity extends over the sensing means and the cavity containing structure has been adhered to the substrate using a process which simultaneously adheres multiple structures to substrates as a single unit, with an adhesive forming a seal between the substrate and structure at a temperature less than approximately 400° C.
Claim 3
Dependent Claim
25 words
The device of claim 1 wherein the material for the machined structure is selected from the group consisting of silicon, glass, and micromachinable organic materials.
Claim 4
Dependent Claim
20 words
The device of claim 1 further comprising a material having a specific chemical reactivity in the cavity of the structure.
Claim 5
Dependent Claim
23 words
The device of claim 3 wherein the material is selected from the group consisting of solid state materials, biological materials, and combinations thereof.
Claim 6
Dependent Claim
50 words
The device of claim 4 wherein the material is selected from the group consisting of valinomycin, liquid polyether ester tetraphenyl borate, silver chloride, LaF 3 , Si 3 N 4 , pH sensitive glass, aluminum oxide, lipid bilayers, lipid bilayers doped with antibiotics, and combinations of proteins and lipid bilayers.
Claim 7
Dependent Claim
30 words
The device of claim 3 wherein the chemically sensitive material is cast into the cavity of the machined structure to form a second cavity between the material and the substrate.
Claim 8
Dependent Claim
14 words
The device of claim 1 wherein the sensing means is a electronically active device.
Claim 9
Dependent Claim
12 words
The device of claim 7 wherein the sensing means is a transistor.
Claim 10
Dependent Claim
14 words
The device of claim 1 wherein the sensing means is a passive electronic device.
Claim 11
Dependent Claim
13 words
The device of claim 9 wherein the sensing means is a conductive film.
Claim 12
Dependent Claim
12 words
The device of claim 1 wherein the sensing means is a circuit.
Claim 13
Dependent Claim
10 words
The device of claim 1 further comprising a reference electrode.
Claim 14
Dependent Claim
9 words
The device of claim 1 further comprising an electrolyte.
Claim 15
Dependent Claim
29 words
The device of claim 1 wherein the cavity containing structure is adhered to the substrate with an adhesive selected from the group of organic adhesives, and spin on glass.
Claim 16
Dependent Claim
20 words
The device of claim 14 wherein the adhesive is selected from the group consisting of a photocurable epoxy or silicon.
Claim 17
Dependent Claim
17 words
The device of claim 1 further comprising means for connecting the microsensor to an external electrical circuit.
Claim 18
Dependent Claim
24 words
The device of claim 1 for sensing a molecule in a solution wherein the sensor is encapsulated with a coating impermeable to the solution.
Claim 19
Dependent Claim
28 words
The device of claim 17 wherein the coating is selected from the group consisting of silicon nitride, aluminum oxide, tantalum oxide, silicon dioxide, polyimide, silicones, and epoxy resins.
Claim 20
Dependent Claim
26 words
The device of claim 1 further comprising at least one cavity containing structure adhered to the upper surface of the cavity containing structures overlying the substrate.
Claim 21
Dependent Claim
19 words
The device of claim 19 further comprising electrolyte wherein the chemically sensitive material and electrolyte are in separate cavities.
Claim 22
Dependent Claim
150 words
A multi-sensor device comprising electrochemical microsensors having a substrate containing microelectronic means for sensing potential or current; a micromachined structure having opening extending into a cavity therein from opposite sides of the structure, wherein said structure has been produces by photolithographic transfer of a two dimensional pattern onto a material to form a three dimensional structure following selective removal of the material, and; wherein the cavity containing-structure has been positioned over the substrate so that an opening into the cavity extends over the sensing means and the cavity containing structure has been adhered to the substrate using a process which simultaneously adheres multiple structures to substrates as a single unit, with an adhesive forming a seal between the substrate and structure at a temperature less than approximately 400° C.; and a chemically sensitive material within the cavity; wherein the electrochemical microsensors contain materials having chemical sensitivities to different chemical species.
Claim 23
Dependent Claim
150 words
A multi-sensor device comprising electrochemical microsensors having a substrate containing microelectronic means for sensing potential or current; a micromachined structure having opening extending into a cavity therein from opposite sides of the structure, wherein said structure has been produces by photolithographic transfer of a two dimensional pattern onto a material to form a three dimensional structure following selective removal of the material, and; wherein the cavity containing-structure has been positioned over the substrate so that an opening into the cavity extends over the sensing means and the cavity containing structure has been adhered to the substrate using a process which simultaneously adheres multiple structures to substrates as a single unit, with an adhesive forming a seal between the substrate and structure at a temperature less than approximately 400° C.; and a chemically sensitive material within the cavity; wherein the electrochemical microsensors contain materials having chemical sensitivities to different chemical species.
Claim 24
Dependent Claim
18 words
The device of claim 1 encapsulated for measuring the concentration of chemical species in a solution or gas.
Claim 25
Independent Claim
122 words
A method for manufacturing a chemical microsensor comprising: (i) providing a substrate containing microelectronic means for sensing potential or current; (ii) providing a micromachined structure having openings extending into a cavity therein from opposite sides of the structure, wherein said structure has been produced by photolithographic transfer of a two dimensional pattern onto a material to form a three dimensional structure following selective removal of the material, and; (iii) positioning the structure containing the cavity over the substrate wherein an opening into the cavity extends over the sensing means; and (iv) using a process to adhere the cavity containing structure to the substrate which simultaneously adheres multiple structures to substrates as a single unit, at a temperature less than approximately 400° C.
Claim 26
Independent Claim
122 words
A method for manufacturing a chemical microsensor comprising: (i) providing a substrate containing microelectronic means for sensing potential or current; (ii) providing a micromachined structure having openings extending into a cavity therein from opposite sides of the structure, wherein said structure has been produced by photolithographic transfer of a two dimensional pattern onto a material to form a three dimensional structure following selective removal of the material, and; (iii) positioning the structure containing the cavity over the substrate wherein an opening into the cavity extends over the sensing means; and (iv) using a process to adhere the cavity containing structure to the substrate which simultaneously adheres multiple structures to substrates as a single unit, at a temperature less than approximately 400° C.
Claim 27
Dependent Claim
24 words
The method of claim 23 further comprising selecting the material for the machined structure from the group consisting of silicon, glass, and photoreactive organics.
Claim 28
Dependent Claim
21 words
The method of claim 23 further comprising providing a material having a specific chemical reactivity in the cavity of the structure.
Claim 29
Dependent Claim
50 words
The method of claim 25 further comprising selecting the material from the group consisting of valinomycin, liquid polyether ester tetraphenyl borate, silver chloride, LaF 3 , Si 3 N 4 , pH sensitive glass, aluminum oxide, lipid bilayers, lipid bilayers doped with antibiotics, and combinations of proteins and lipid bilayers.
Claim 30
Dependent Claim
28 words
The method of claim 25 wherein the material is cast into the cavity of the machined structure to form a second cavity between the material and the substrate.
Claim 31
Dependent Claim
14 words
The method of claim 23 wherein the sensing means is an electronically active device.
Claim 32
Dependent Claim
12 words
The method of claim 28 wherein the sensing means is a transistor.
Claim 33
Dependent Claim
14 words
The method of claim 23 wherein the sensing means is a passive electronic device.
Claim 34
Dependent Claim
13 words
The method of claim 30 wherein the sensing means is a conductive film.
Claim 35
Dependent Claim
12 words
The method of claim 23 wherein the sensing means is a circuit.
Claim 36
Dependent Claim
11 words
The method of claim 23 further comprising providing a reference electrode.
Claim 37
Dependent Claim
10 words
The method of claim 23 further comprising providing an electrolyte.
Claim 38
Dependent Claim
29 words
The method of claim 23 wherein the cavity containing structure is adhered to the substrate with an adhesive selected from the group of organic adhesives, and spin on glass.
Claim 39
Dependent Claim
18 words
The method of claim 23 further comprising encapsulating the sensor with a coating impermeable to the external environment.
Claim 40
Dependent Claim
28 words
The method of claim 36 wherein the coating is selected from the group consisting of silicon nitride, aluminum oxide, tantalum oxide, silicon dioxide, polyimide, silicones, and epoxy resins.
Claim 41
Dependent Claim
22 words
The method of claim 23 further comprising adhering additional cavity containing structures to the cavity containing structures overlying the device containing substrate.
Claim 42
Dependent Claim
19 words
The method of claim 38 further comprising providing material sensitive to different chemical species and electrolyte in separate cavities.
Claim 43
Dependent Claim
14 words
The method of claim 39 further comprising placing the devices on a single chip.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-10-16 | 1993-04-17 | 1993-10-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-10-16 | 1997-04-17 | 1997-10-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-10-16 | 2001-04-17 | 2001-10-17 | $7700.00 | Window Closed / Lapsed |