Patent US5094876A successfully refreshed from Google Patents.
US5094876A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Surface modified surgical instruments, devices, implants, contact lenses and the like
Assignee: University of Florida Research Foundation Inc
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Filing: 1990-10-05
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Granted: 1992-03-10
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Expires: 2010-10-05
Abstract
Abstract An improved method for modifying the plastic surfaces of articles adapted for contacting living tissue by the gamma or electron beam irradiation induced chemical graft coating thereon of a monomer comprising N-vinylpyrrolidone, 2-hydroxyethylmethacrylate or a mixture of the two to form a hydrophilic graft polymer coating, the improvement comprising pre-soaking the ocular implant material in a monomer or a solution comprising a monomer prior to conducting the gamma- or electron beam-irradiation induced graft polymerization in a second solution of a monomer.
Inventors
- 👤 Eugene P. Goldberg
- 👤 Ali Vahiaoui
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 16:03
CPC Classifications
A; A61; A61F; A61F2/00; A61F2/0077; A61F2/02; A61F2/14; A61F2/16; A61F2/1662; A61F2/1664; A61F2002/009; A61L; A61L2400/00; A61L2400/18; A61L2430/00; A61L2430/16; Y; Y10; Y10S; Y10S623/00; Y10S623/92; Y10T; Y10T428/00; Y10T428/31504; Y10T428/31786; Y10T428/3179; Y10T428/31794; Y10T428/31797
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
272 words
In a method for modifying a plastic surface of an article, said surface adapted for contact with living tissue of a human or non-human animal, by the gamma-irradiation induced polymerized chemically grafted coating thereon of: 1) a monomer comprising N-vinylpyrrolidone (NVP), 2) a monomer comprising 2-hydroxyethyl-methacrylate (HEMA), 3) a mixture of (NVP) and (HEMA), (NVP-HEMA), or 4) a mixture of 1), 2) or 3) with up to about 50 wt %, based on the total monomer weight, of an ionic monomer, salt of an ionic monomer or mixture thereof; so as to form a hydrophilic graft polymer coating of: I. polyvinylpyrrolidone (PVP), II. poly-2-hydroxyethylmethacrylate (PHEMA), III. a copolymer of (NVP) and (HEMA), [P(NVP-HEMA)], or IV. a copolymer of (NVP), (HEMA) or (NVP-HEMA) and said ionic monomer, on said surface, the improvement comprising: a) pre-soaking said plastic surface in at least one of said monomers or in a first aqueous solution of at least one of said monomers, having a concentration of monomer therein of from about 5 to about 95%, by weight, and conducting said gamma-irradiation induced graft polymerization in a second aqueous solution of at least one of said monomers under the following conditions: b) monomer concentration in the range of from about 0.1% to about 50%, by weight; c) total gamma dose in the range of from about 0.001 to less than about 0.50 Mrad; and d) gamma dose rate in the range of from about 10 to about 2500 rads/min; said pre-soaking in step a) being conducted for a period of time and at a temperature sufficient to facilitate diffusion of said monomer or monomers into said plastic surface.
Claim 2
Dependent Claim
272 words
In a method for modifying a plastic surface of an article, said surface adapted for contact with living tissue of a human or non-human animal, by the gamma-irradiation induced polymerized chemically grafted coating thereon of: 1) a monomer comprising N-vinylpyrrolidone (NVP), 2) a monomer comprising 2-hydroxyethyl-methacrylate (HEMA), 3) a mixture of (NVP) and (HEMA), (NVP-HEMA), or 4) a mixture of 1), 2) or 3) with up to about 50 wt %, based on the total monomer weight, of an ionic monomer, salt of an ionic monomer or mixture thereof; so as to form a hydrophilic graft polymer coating of: I. polyvinylpyrrolidone (PVP), II. poly-2-hydroxyethylmethacrylate (PHEMA), III. a copolymer of (NVP) and (HEMA), [P(NVP-HEMA)], or IV. a copolymer of (NVP), (HEMA) or (NVP-HEMA) and said ionic monomer, on said surface, the improvement comprising: a) pre-soaking said plastic surface in at least one of said monomers or in a first aqueous solution of at least one of said monomers, having a concentration of monomer therein of from about 5 to about 95%, by weight, and conducting said gamma-irradiation induced graft polymerization in a second aqueous solution of at least one of said monomers under the following conditions: b) monomer concentration in the range of from about 0.1% to about 50%, by weight; c) total gamma dose in the range of from about 0.001 to less than about 0.50 Mrad; and d) gamma dose rate in the range of from about 10 to about 2500 rads/min; said pre-soaking in step a) being conducted for a period of time and at a temperature sufficient to facilitate diffusion of said monomer or monomers into said plastic surface.
Claim 3
Dependent Claim
39 words
The method of claim 1 wherein said pre-soaking step is conducted at a temperature in the range of from about 25° to about 90° C. and for a period of time of from about 0.5 to about 48 hours.
Claim 4
Dependent Claim
12 words
The method of claim 1 wherein said article is a surgical instrument.
Claim 5
Dependent Claim
12 words
The method of claim 1 wherein said article is a medical device.
Claim 6
Dependent Claim
12 words
The method of claim 1 wherein said article is a prosthetic implant.
Claim 7
Dependent Claim
15 words
The method of claim 1 wherein said article is a soft or hard contact lens.
Claim 8
Dependent Claim
20 words
The method of claim 1 wherein said ionic monomer is a vinylsulfonic acid, a vinylcarboxylic acid or a salt thereof.
Claim 9
Dependent Claim
15 words
The method of claim 7 wherein said vinyl-carboxylic acid is acrylic, methacrylic or crotonic acid.
Claim 10
Dependent Claim
18 words
The method of claim 7 wherein said vinylsulfonic acid is sulfoethylmethacrylate, sulfopropylmethacrylate, styrene sulfonic acid or vinylsulfonic acid.
Claim 11
Dependent Claim
13 words
The method of claim 1 wherein said ionic monomer is an amino-functional monomer.
Claim 12
Dependent Claim
19 words
The method of claim 10 wherein said amino-functional monomer is a vinylpyridine, an amino-styrene, an aminoacrylate or an aminomethacrylate.
Claim 13
Dependent Claim
35 words
The method of claim 1 wherein said plastic is selected from the group consisting of polyacrylates, polymethacrylates, polyolefins, ethylene-propylene copolymers, polybutadiene, styrene-butadiene copolymers, styrene-ethylene-butadiene copolymers, polycarbonates, fluorocarbon polymers, polysiloxanes, polyurethanes, polyvinylchloride, polyesters and mixtures thereof.
Claim 14
Independent Claim
291 words
A method for modifying a plastic surface of an article, said surface adapted for contact with living tissue of a human or non-human animal, by the one-step electron beam-irradiation induced polymerized chemically grafted coating thereon of: 1) a monomer comprising N-vinylpyrrolidone (NVP), 2) a monomer comprising 2-hydroxyethyl-methacrylate (HEMA), 3) a mixture of (NVP) and (HEMA), (NVP-HEMA), or 4) a mixture of 1), 2) or 3) with up to about 50 wt %, based on the total monomer weight, of an ionic monomer, salt of an ionic monomer or mixture thereof; so as to form a hydrophilic graft polymer coating of: I. polyvinylpyrrolidone (PVP), II. poly-2-hydroxyethylmethacrylate (PHEMA), III. a copolymer of (NVP) and (HEMA), [P(NVP-HEMA)], or IV. a copolymer of (NVP), (HEMA) or (NVP-HEMA) and said ionic monomer, on said surface comprising: a) pre-soaking said plastic surface in at least one of said monomers or in a first aqueous solution of at least one of said monomers, having a concentration of monomer therein of from about 5 to about 95%, by weight, and conducting said electron beam-irradiation induced graft polymerization in a second aqueous solution of at least one of said monomers under the following conditions: b) monomer concentration in the range of from about 0.1% to about 50%, by weight; c) total electron beam irradiation dose equivalent to a gamma irradiation dose in the range of from about 0.001 to less than about 0.50 Mrad; and d) an electron beam irradiation dose rate equivalent to a gamma irradiation dose rate in the range of from about 10 to about 10 8 rads/min; said pre-soaking in step a) being conducted for a period of time and at a temperature sufficient to facilitate diffusion of said monomer or monomers into said plastic surface.
Claim 15
Independent Claim
291 words
A method for modifying a plastic surface of an article, said surface adapted for contact with living tissue of a human or non-human animal, by the one-step electron beam-irradiation induced polymerized chemically grafted coating thereon of: 1) a monomer comprising N-vinylpyrrolidone (NVP), 2) a monomer comprising 2-hydroxyethyl-methacrylate (HEMA), 3) a mixture of (NVP) and (HEMA), (NVP-HEMA), or 4) a mixture of 1), 2) or 3) with up to about 50 wt %, based on the total monomer weight, of an ionic monomer, salt of an ionic monomer or mixture thereof; so as to form a hydrophilic graft polymer coating of: I. polyvinylpyrrolidone (PVP), II. poly-2-hydroxyethylmethacrylate (PHEMA), III. a copolymer of (NVP) and (HEMA), [P(NVP-HEMA)], or IV. a copolymer of (NVP), (HEMA) or (NVP-HEMA) and said ionic monomer, on said surface comprising: a) pre-soaking said plastic surface in at least one of said monomers or in a first aqueous solution of at least one of said monomers, having a concentration of monomer therein of from about 5 to about 95%, by weight, and conducting said electron beam-irradiation induced graft polymerization in a second aqueous solution of at least one of said monomers under the following conditions: b) monomer concentration in the range of from about 0.1% to about 50%, by weight; c) total electron beam irradiation dose equivalent to a gamma irradiation dose in the range of from about 0.001 to less than about 0.50 Mrad; and d) an electron beam irradiation dose rate equivalent to a gamma irradiation dose rate in the range of from about 10 to about 10 8 rads/min; said pre-soaking in step a) being conducted for a period of time and at a temperature sufficient to facilitate diffusion of said monomer or monomers into said plastic surface.
Claim 16
Dependent Claim
12 words
An article prepared according to the method of claim 1 or 13.
Claim 17
Dependent Claim
17 words
An article according to claim 14 comprising a surgical instrument, medical device, prosthetic implant or contact lens.
References Cited (Backward Citations)
US4897433A
Cited
US4961954A
Cited
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