Patent US5093129A successfully refreshed from Google Patents.
US5093129A
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Method for treating addiction to a drug of abuse employing an ace inhibitor
Assignee: ER Squibb and Sons LLC
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Filing: 1989-01-30
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Granted: 1992-03-03
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Expires: 2009-01-30
Abstract
Abstract A method is provided for treating addiction to a drug of abuse such as nicotine, cocaine or diazepam, by inhibiting appetitie or desire for such drug by administering an ACE inhibitor, such as captopril, fosinopril, zofenopril or SQ 29,852, alone or in combination with a calcium channel blocker such as diltiazem or nifedipine, over a prolonged period of treatment.
Inventors
- 👤 Zola P. Horovitz
- 👤 Abraham Sudilovsky
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 13:07
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/435; A61K31/44; A61K31/40; A61K31/55; A61K31/66; A61K38/00; A61K38/04; A61K38/05; A61K38/16; A61K38/55; A61K38/556; A61P; A61P25/00; A61P25/30; A61P3/00; A61P3/12; A61P3/14
Claims Analysis
Total Claims: 24
Claim 1
Independent Claim
106 words
A method for treating addiction to a drug of abuse in a mammalian specie, which comprises administering to a mammalian specie in need of such treatment an antiaddictive effective amount of an angiotensin converting enzyme inhibitor selected from the group consisting of catopril, (S)-1-[6-amino-2-[[hydroxy(4-phenylbutyl) phosphinoyl]oxy]-1-oxohexyl]-L-proline, fosinopril, zofenopril enalapril and lisinopril alone or in combination with a calcium channel blocker wherein said inhibitor is administered in single or divided doses of from about 0.1 to about 500 mg/ one to four time daily and the calcium channel blocker is administered in single or divided doses of from about 1 to about 300 mg/1 to 4 times daily.
Claim 2
Independent Claim
106 words
A method for treating addiction to a drug of abuse in a mammalian specie, which comprises administering to a mammalian specie in need of such treatment an antiaddictive effective amount of an angiotensin converting enzyme inhibitor selected from the group consisting of catopril, (S)-1-[6-amino-2-[[hydroxy(4-phenylbutyl) phosphinoyl]oxy]-1-oxohexyl]-L-proline, fosinopril, zofenopril enalapril and lisinopril alone or in combination with a calcium channel blocker wherein said inhibitor is administered in single or divided doses of from about 0.1 to about 500 mg/ one to four time daily and the calcium channel blocker is administered in single or divided doses of from about 1 to about 300 mg/1 to 4 times daily.
Claim 3
Dependent Claim
43 words
The method as defined in claim 1 wherein the angiotensin converting enzyme inhibitor is a phosphonate substituted amino or imino acid or salt thereof, a proline derivative, a substituted proline derivative, a carboxyalkyl dipeptide derivative, a phosphinylalkanoyl proline derivative or a phosphonamidate derivative.
Claim 4
Dependent Claim
22 words
The method as defined in claim 1 wherein said angiotensin converting enzyme inhibitor is a proline derivative or a substituted proline derivative.
Claim 5
Dependent Claim
18 words
The method as defined in claim 1 wherein said angiotensin converting enzyme inhibitor is a carboxyalkyl dipeptide derivative.
Claim 6
Dependent Claim
32 words
The method as defined in claim 1 wherein said angiotensin converting enzyme inhibitor is a phosphinylalkanoyl proline derivative, a phosphoramidate derivative, or a phosphonate substituted amino or imino acid or salt thereof.
Claim 7
Dependent Claim
15 words
The method as defined in claim 1 wherein said angiotensin converting enzyme inhibitor is captopril.
Claim 8
Dependent Claim
15 words
The method as defined in claim 1 wherein said angiotensin converting enzyme inhibitor is enalapril.
Claim 9
Dependent Claim
15 words
The method as defined in claim 1 wherein said angiotensin converting enzyme inhibitor is lisinopril.
Claim 10
Dependent Claim
15 words
The method as defined in claim 1 wherein said angiotensin converting enzyme inhibitor is zofenopril.
Claim 11
Dependent Claim
15 words
The method as defined in claim 1 wherein said angiotensin converting enzyme inhibitor is fosinopril.
Claim 12
Dependent Claim
15 words
The method as defined in claim 1 wherein said angiotensin converting enzyme inhibitor is (S)-1-[6-amino-2-[[hydroxy(4-phenylbutyl)phosphinyl]oxy]-1-oxohexyl]-L-proline.
Claim 13
Dependent Claim
20 words
The method as defined in claim 1 wherein the angiotensin converting enzyme inhibitor is administered with a calcium channel blocker.
Claim 14
Dependent Claim
18 words
The method as defined in claim 12 wherein the calcium channel blocker is diltiazem, a 4-phenyl-1,4-dihydropyridine or verapamil.
Claim 15
Dependent Claim
14 words
The method as defined in claim 13 wherein the 4-phenyl-1,4-dihydropyridine is nifedipine or nitrendipine.
Claim 16
Dependent Claim
35 words
The method as defined in claim 12 wherein the angiotensin converting enzyme inhibitor is employed in a weight ratio to the calcium channel blocker of within the range of from about 0.1:1 to about 10:1.
Claim 17
Dependent Claim
22 words
The method as defined in claim 1 wherein the drug of abuse is nicotine, cocaine, diazepam, an amphetamine, morphine, heroin or marihuana.
Claim 18
Independent Claim
41 words
A method for inhibiting appetite or desire for nicotine, in a mammalian specie, which comprises administering to a mammalian specie in need of such treatment an antiadditive effective amount of an angiotensin converting enzyme inhibitor in combination with calcium channel blocker.
Claim 19
Independent Claim
41 words
A method for inhibiting appetite or desire for nicotine, in a mammalian specie, which comprises administering to a mammalian specie in need of such treatment an antiadditive effective amount of an angiotensin converting enzyme inhibitor in combination with calcium channel blocker.
Claim 20
Independent Claim
46 words
A method for inhibiting appetite or desire for heroin, cocaine, morphine or marihuana in a mammalian specie, which comprises administering to a mammalian specie in need of such treatment an antiadditive effective amount of an angiotensin converting enzyme inhibitor in combination with a calcium channel blocker.
Claim 21
Independent Claim
46 words
A method for inhibiting appetite or desire for heroin, cocaine, morphine or marihuana in a mammalian specie, which comprises administering to a mammalian specie in need of such treatment an antiadditive effective amount of an angiotensin converting enzyme inhibitor in combination with a calcium channel blocker.
Claim 22
Dependent Claim
23 words
The method as defined in claim 18 wherein the angiotensin converting enzyme inhibitor administered is SQ 29,852, captopril, fosinopril, zofenopril, enalapril or lisinopril.
Claim 23
Independent Claim
48 words
A method for inhibiting appetite or desire for diazepam or other benzodiazepine or an amphetamine in a mammalian specie, which comprises administering to a mammalian specie in need of such treatment an antiadditive effective amount of an angiotensin converting enzyme inhibitor in combination with a calcium channel blocker.
Claim 24
Independent Claim
48 words
A method for inhibiting appetite or desire for diazepam or other benzodiazepine or an amphetamine in a mammalian specie, which comprises administering to a mammalian specie in need of such treatment an antiadditive effective amount of an angiotensin converting enzyme inhibitor in combination with a calcium channel blocker.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-03-03 | 1995-09-02 | 1996-03-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-03-03 | 1999-09-02 | 2000-03-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-03-03 | 2003-09-02 | 2004-03-03 | $7700.00 | Window Closed / Lapsed |