Benzofused lactams useful as antihypertensive agents and as cholecystokinin antagonists

Claim 1

A compound of the formula: ##STR29## wherein: R 1 is hydrogen; straight chain or branched, saturated or unsaturated hydrocarbon of 1 to 12 carbon atoms; C 3 -C 10 cycloalkyl; substituted C 1 -C 6 alkyl wherein the substituent can be halo, hydroxy, carboxy, C 1 -C 6 alkylthio, C 1 -C 6 alkoxy, C 1 -C 6 alkoxycarbonyl, carboxamido, aryl-C 1 -C 6 -C 6 -alkoxycarbonyl, amino, C 1 -C 6 alkylamino, di-C 1 -C 6 -alkylamino, C 1 -C 6 alkanoylamino, or aroylamino; substituted C 1 -C 6 alkyl having the formula R A 1 (CH 2 ) p --Q--(CH 2 ) q wherein p is 0-2, q is 1-3, R A 1 is aryl or heteroaryl optionally substituted by amino, di-C 1 -C 6 -alkylamino, C 1 -C 6 alkylamino, hydroxy, hydroxy-C 1 -C 6 -alkyl, amino-C 1 -C 6 -alkyl, thihalo-C 1 -C 6 -alkyl, cyano, nitro, sulfonamido, aroyl, C 1 -C 6 alkyl, halo, dihalo, and C 1 -C 6 alkoxy, and Q is O, S, N-R B 1 , CONR C 1 , NR C 1 CO, CH═CH wherein R B 1 is hydrogen, C 1 -C 6 alkyl, aryl, aryl-C 1 -C 6 -alkyl, C 1 -C 6 alkanoyl, or aroyl, and R C 1 is hydrogen, or C 1 -C 6 alkyl; aryl; substituted aryl wherein the substituent is C 1 -C 6 alkyl, amino-C 1 -C 6 -alkyl, C 1 -C 6 alkoxy, aryloxy, aroyl, hydroxy, halo, or dihalo; aryl-C 1 -C 6 alkyl or heteroaryl-C 1 -C 6 -alkyl which include branched C 1 -C 6 alkyl groups; substituted aryl-C 1 -C 6 alkyl or substituted heteroaryl-C 1 -C 6 alkyl which include branched C 1 -C 6 alkyl groups wherein the alkyl groups can be substituted by amino, C 1 -C 6 alkanoylamino, aroylamino, or hydroxyl and the aryl and heteroaryl groups can be substituted by halo, dihalo, C 1 -C 6 alkyl, hydroxy, C 1 -C 6 alkoxy, aryloxy, aroyl, arylthio, amino, amino-C 1 -C 6 -alkyl, C 1 -C 6 alkanoylamino, aroylamino, di-C 1 -C 6 -alkylamino, C 1 -C 6 alkylamino, hydroxy-C 1 -C 6 -alkyl, trihalo-C 1 -C 6 -alkyl, nitro, cyano, or sulfonamido; R 2 is hydroxy; C 1 -C 6 alkoxy; C 1 -C 6 alkenyloxy; aryl-C 1 -C 6 -alkoxy; amino; C 1 -C 6 alkylamino; di-C 1 -C 6 -alkylamino; aryl-C 1 -C 6 alkylamino; arylamino; carboxy-C 1 -C 6 -alkylamino; carboxamido-C 1 -C 6 -alkylamino; aryloxy, or mono- or disubstituted aryloxy wherein the substituents are halo; m is 1-3; R 3 is C 1 -C 6 alkyl or substituted C 1 -C 6 alkyl wherein the substituents are hydrogen, C 1 -C 6 alkyl, or aryl; R 4 is hydroxy; C 1 -C 6 alkanoyloxy; aryl-C 1 -C 6 -alkanoyloxy; R 5 is hydrogen; halo; hydroxy; C 1 -C 6 alkyl; or C 1 -C 6 alkoxy; and, a pharmaceutically acceptable salt thereof wherein in said R 1 -R 5 groups aryl is a member of the group consisting of phenyl, naphthyl, or biphenyl; and, heteroaryl is a 5- or 6-membered aromatic ring containing from one to three O, N or S heteroatoms and in a member selected from the group consisting pyridyl, thienyl, furyl, imidazolyl, and thiazolyl as well as bicyclic groups in which a heteroaryl ring is fused to a benzene ring, said bicyclic groups being a member selected from the group consisting of indolyl, quinolinyl, isoquinolinyl, benzimidazolyl, benzothiazolyl, and benzthienzyl.