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US5089146A
Expired / Lapsed
US
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Pre-storage filtration of platelets
Assignee: Bayer Corp
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Filing: 1990-02-12
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Granted: 1992-02-18
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Expires: 2010-02-12
Abstract
Abstract Filtration of white blood cells (WBCs) directly from platelet rich plasma (PRP) rather than from subsequently made platelet concentrates (PC). Earlier filtration is effective at removing most WBCs with minimal platelet loss and permits storage of platelets for at least 5 days. The filtration is preferably done with a closed, ready-to-use system comprising a WBC filter disposed between a first blood bag and at least two empty secondary bags. A fourth bag may be included in the closed system to contain a platelet additive solution. System can remove at least 95% of the WBCs with less than 10% loss in platelets. In very preferred embodiments at least 99.5% of the original WBCs are removed by filtration prior to platelet storage.
Inventors
- 👤 Raleigh A. Carmen
- 👤 Edward J. Nelson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 16:24
CPC Classifications
A; A61; A61M; A61M1/00; A61M1/02; A61M1/0209; A61M1/0218; A61M2202/00; A61M2202/04; A61M2202/0413; A61M2202/0415; A61M2202/0427; A61M2202/0439
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
71 words
A method of preparing platelets for long term storage comprising the steps of (a) obtaining whole blood from a human; (b) preparing platelet rich plasma from the whole blood; and (c) then passing the platelet rich plasma through a filter under conditions sufficient to remove substantially all white blood cells from the plasma, with steps (b) and (c) occurring in a closed blood bag system within eight hours of step (a).
Claim 2
Independent Claim
71 words
A method of preparing platelets for long term storage comprising the steps of (a) obtaining whole blood from a human; (b) preparing platelet rich plasma from the whole blood; and (c) then passing the platelet rich plasma through a filter under conditions sufficient to remove substantially all white blood cells from the plasma, with steps (b) and (c) occurring in a closed blood bag system within eight hours of step (a).
Claim 3
Dependent Claim
30 words
The method of claim 1 wherein the filtration step is under conditions that result in a loss of less than 10% of the original platelets in the platelet rich plasma.
Claim 4
Dependent Claim
21 words
The method of claim 1 wherein the filtration is under conditions that remove at least 95% of the white blood cells.
Claim 5
Dependent Claim
21 words
The method of claim 1 wherein the filtration is under conditions that remove at least 99.5% of the white blood cells.
Claim 6
Dependent Claim
23 words
The method of claim 1 which includes the additional step of adding a platelet storage solution to the filtered platelets after step (c).
Claim 7
Dependent Claim
22 words
The method of claim 6 where the platelet storage solution is in closed communication with and a part of the closed system.
Claim 8
Dependent Claim
56 words
A closed system for the pre-storage filtration of platelets comprising a first blood bag connected via a first tubing to a white blood cell filter which is connected via a second tubing to a platelet storage bag, and a bag containing a platelet storage solution which is also connected via tubing to the platelet storage bag.
Claim 9
Dependent Claim
56 words
A closed system for the pre-storage filtration of platelets comprising a first blood bag connected via a first tubing to a white blood cell filter which is connected via a second tubing to a platelet storage bag, and a bag containing a platelet storage solution which is also connected via tubing to the platelet storage bag.
Claim 10
Dependent Claim
30 words
The system of claim 8 wherein the platelet storage bag is made from plastic film selected from the group consisting of polyvinyl chloride plasticized with trioctyltrimellitate and ethylene vinyl acetate.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-02-17 | 1995-08-19 | 1996-02-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-02-17 | 1999-08-19 | 2000-02-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-02-17 | 2003-08-19 | 2004-02-18 | $7700.00 | Window Closed / Lapsed |