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US5079231A Expired / Lapsed US ⏱️ 0.0 years remaining

Immunostimulating peptides, a process for their preparation and pharmaceutical compositions containing them

Assignee: Ellem Industria Farmaceutica SpA
•
Filing: 1989-07-24
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Granted: 1992-01-07
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Expires: 2009-07-24
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Abstract

Abstract The peptides of formula I A--x--Lys--y--B I in which: A is H, a tripeptide of formula Arg-Ala-Arg or an hexapeptide of formula Glu-Lys-Arg-Arg-Ala-Arg x and y, different one from the other, are an arginine (Arg) or a glutamic acid (Glu) residue; B is OH or a tripeptide Arg-Ala-Arg with the proviso that when A is hydrogen and x is ARg, B is different from OH comprising the steps of: a) binding the Boc-protected carboxyterminal aminoacid to a suitable resin; b) reacting the other Boc-protected aminoacids with the resin-bound carboxyterminal aminoacid in the desired sequence; c) removing the protecting groups and releasing the so obtained peptides from the resin, have valuable pharmacological properties as immunostimulating agents.

Inventors

  • 👤 Brunetto Brunetti
  • 👤 Marco Prada

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-11-09 03:51
CPC Classifications
C; C07; C07K; C07K7/00; C07K7/04; C07K7/06; A; A61; A61P; A61P37/00; A61P37/02; A61P37/04; C07K14/00; C07K14/435; C07K14/575; C07K14/66; C07K14/662; C07K5/00; C07K5/04; C07K5/08; C07K5/0819; A61K; A61K38/00; Y; Y02; Y02P; Y02P20/00; Y02P20/50; Y02P20/55

Claims Analysis

Total Claims: 6
Claim 1
Independent Claim 22 words
A peptide selected from the group consisting of Arg-Lys-Glu-Arg-Ala-Arg, Arg-Lys-Glu-Arg-D-Ala-Arg, Arg-Ala-Arg-Arg-Lys-Glu, Arg-D-Ala-Arg-Arg-Lys-Glu, Arg-Ala-Arg-Arg-Lys-Glu-Arg-Ala-Arg, Arg-Ala-Arg-Glu-Lys-Arg-, Glu-Lys-Arg-Arg-Ala-Arg, Glu-Lys-Arg-Arg-Ala-Arg-Glu-Lys-Arg, and a pharmaceutically acceptable salt thereof.
Claim 2
Dependent Claim 22 words
A peptide selected from the group consisting of Arg-Lys-Glu-Arg-Ala-Arg, Arg-Lys-Glu-Arg-D-Ala-Arg, Arg-Ala-Arg-Arg-Lys-Glu, Arg-D-Ala-Arg-Arg-Lys-Glu, Arg-Ala-Arg-Arg-Lys-Glu-Arg-Ala-Arg, Arg-Ala-Arg-Glu-Lys-Arg-, Glu-Lys-Arg-Arg-Ala-Arg, Glu-Lys-Arg-Arg-Ala-Arg-Glu-Lys-Arg, and a pharmaceutically acceptable salt thereof.
Claim 3
Dependent Claim 17 words
A Peptide according to claim 1 wherein the aminoacids are of the D-, L- or DL series.
Claim 4
Dependent Claim 17 words
The peptide, according to claim 1, wherein said salt is the acetate, trifluoroacetate, sulfate, or hydrochloride salt.
Claim 5
Dependent Claim 44 words
A pharmaceutical composition having immunostimulating activity comprising as the active principle an effective amount of a peptide selected from the group consisting of Arg-Lys-Glu-Arg-Ala-Arg, Arg-Lys-Glu-Arg-D-Ala-Arg, Arg-Ala-Arg-Arg-Lys-Glu, Arg-D-Ala-Arg-Arg-Lys-Glu, Arg-Ala-Arg-Arg-Lys-Glu-Arg-Ala-Arg, Arg-Ala-Arg-Glu-Lys-Arg, Glu-Lys-Arg-Arg-Ala-Arg, Glu-Lys-Arg-Arg-Ala-Arg-Glu-Lys-Arg and a pharmaceutically acceptable salt thereof in a mixture with an acceptable carrier.
Claim 6
Dependent Claim 44 words
A pharmaceutical composition having immunostimulating activity comprising as the active principle an effective amount of a peptide selected from the group consisting of Arg-Lys-Glu-Arg-Ala-Arg, Arg-Lys-Glu-Arg-D-Ala-Arg, Arg-Ala-Arg-Arg-Lys-Glu, Arg-D-Ala-Arg-Arg-Lys-Glu, Arg-Ala-Arg-Arg-Lys-Glu-Arg-Ala-Arg, Arg-Ala-Arg-Glu-Lys-Arg, Glu-Lys-Arg-Arg-Ala-Arg, Glu-Lys-Arg-Arg-Ala-Arg-Glu-Lys-Arg and a pharmaceutically acceptable salt thereof in a mixture with an acceptable carrier.

References Cited (Backward Citations)

US4650788A Cited
US4505853A Cited
US4874844A Cited
US4929601A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1995-01-06 1995-07-08 1996-01-07 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1999-01-06 1999-07-08 2000-01-07 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 2003-01-06 2003-07-08 2004-01-07 $7700.00 Window Closed / Lapsed

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