US4650788A
Expired / Lapsed
US
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Novel peptides having an immunostimulating action, processes for their preparation and their use
Assignee: Hoechst AG
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Filing: 1984-08-01
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Granted: 1987-03-17
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Expires: 2004-08-01
Abstract
Abstract The invention relates to cyclopeptides of the formula I ##STR1## in which A denotes Lys, D-Lys, Arg or D-Arg, B denotes Lys, D-Lys, Arg or D-Arg, C denotes Asp, D-Asp, Glu or D-Glu, U denotes Val or D-Val and D denotes Tyr, D-Tyr, Trp, D-Trp, Phe or D-Phe, 1 to 4 of the radicals A, B, C, U and D being in the L-configuration and the remaining radicals being in the D-configuration, processes for their preparation, their use and peptidic precursors and processes for their preparation.
Inventors
- 👤 Horst Kessler
- 👤 Bernhard Kutscher
- 👤 Rainer Obermeier
- 👤 Hubert Mullner
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 06:58
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/575; C07K14/66; C07K14/662; A; A61; A61K; A61K38/00; Y; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/18; Y10S930/27
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
74 words
A cyclopeptide of the formula I ##STR10## in which A denotes Lys, D-Lys, Arg or D-Arg, B denotes Lys, D-Lys, Arg or D-Arg, C denotes Asp, D-Asp, Glu or D-Glu, U denotes Val or D-Val and D denotes Tyr, D-Tyr, Trp, D-Trp, Phe or D-Phe, 1 to 4 of the radicals A, B, C, U and D being in the L-configuration and the remainder being in the D-configuration, and a physiologically acceptable salt thereof.
Claim 2
Dependent Claim
74 words
A cyclopeptide of the formula I ##STR10## in which A denotes Lys, D-Lys, Arg or D-Arg, B denotes Lys, D-Lys, Arg or D-Arg, C denotes Asp, D-Asp, Glu or D-Glu, U denotes Val or D-Val and D denotes Tyr, D-Tyr, Trp, D-Trp, Phe or D-Phe, 1 to 4 of the radicals A, B, C, U and D being in the L-configuration and the remainder being in the D-configuration, and a physiologically acceptable salt thereof.
Claim 3
Dependent Claim
35 words
A cyclopeptide as claimed in claim 1, in which A denotes D-Lys or Arg, B denotes Lys, D-Lys or Arg, C denotes Asp or Glu, U denotes D-Val and D denotes Tyr, Trp or D-Phe.
Claim 4
Dependent Claim
11 words
A cyclopeptide as claimed in claim 1, wherein U denotes Val.
Claim 5
Dependent Claim
143 words
A peptide of the formula II ##STR11## in which W denotes Lys (R 1 ), D-Lys (R 1 ), Arg (R 2 ) or D-Arg (R 2 ), X denotes Lys (R 1 ), D-Lys (R 1 ), Arg (R 2 ) or D-Arg (R 2 ) and Y denotes Asp (R 3 ), D-Asp (R 3 ), Glu (R 3 ) or D-Glu (R 3 ) and U and D are as defined in claim 1, and in which R 1 represents a urethane-protective group, R 2 represents a protective group for the guanidino function and R 3 represents an ester-protective group, and (a) all five radicals a represent peptide bonds or (b) one of the radicals a denotes a C-terminal OH together with an N-terminal H (a=--OH+H--) of two aminoacid radicals and the remaining four radicals a each denote peptide bonds.
Claim 6
Dependent Claim
36 words
A pharmaceutical composition for treating deficiencies of immunity comprising an effective amount of a compound or a mixture of compounds as claimed in claim 1 or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier.
Claim 7
Dependent Claim
21 words
A method for influencing the maturing of lymphocytes which comprises treating said lymphocytes with a compound as claimed in claim 1.
Claim 8
Dependent Claim
26 words
A method of treating deficiencies of immunity by administering an effective amount of a compound as claimed in claim 1 or a pharmaceutically acceptable salt thereof.
Claim 9
Dependent Claim
25 words
A cyclopeptide as claimed in claim 1 in which A denotes Arg, B denotes Lys, C denotes Glu, U denotes D-Val and D denotes Tyr.
References Cited (Backward Citations)
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Cited
GB1565032A
Cited
EP0037246A2
Cited
US4298523A
Cited
US4505853A
Cited
US4547489A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-03-16 | 1990-09-15 | 1991-03-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-03-16 | 1994-09-15 | 1995-03-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-03-16 | 1998-09-15 | 1999-03-17 | $7700.00 | Window Closed / Lapsed |