US4547489A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Conformationally restricted thymopentin-like compounds
Assignee: Ortho Pharmaceutical Corp
•
Filing: 1984-06-11
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Granted: 1985-10-15
•
Expires: 2004-06-11
Abstract
Abstract Immunoregulating peptides are disclosed which are cyclic peptides similar to thymopentin. These peptides are useful for their effects on the immune system, especially the treatment of thymic deficiencies.
Inventors
- 👤 Gideon Goldstein
- 👤 George Heavner
- 👤 Tapan Audhya
- 👤 Foe-Siong Tjoeng
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 07:07
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/575; C07K14/66; A; A61; A61P; A61P37/00; A61K; A61K38/00; Y; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/18; Y10S930/27
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
66 words
A peptide having the formula: ##STR5## or a pharmaceutically-acceptable acid- or base-addition salt thereof, wherein: R is H, loweralkyl, formyl or loweralkanoyl; W is LYS, PRO, dehydro-PRO, or AIB; Z is TYR, TYR-GLY, PHE, or PHE-GLY; Z 1 is TYR or PHE; R 1 is OH or NR 2 R 3 ; and R 2 and R 3 are each independently selected from H or loweralkyl.
Claim 2
Dependent Claim
66 words
A peptide having the formula: ##STR5## or a pharmaceutically-acceptable acid- or base-addition salt thereof, wherein: R is H, loweralkyl, formyl or loweralkanoyl; W is LYS, PRO, dehydro-PRO, or AIB; Z is TYR, TYR-GLY, PHE, or PHE-GLY; Z 1 is TYR or PHE; R 1 is OH or NR 2 R 3 ; and R 2 and R 3 are each independently selected from H or loweralkyl.
Claim 3
Dependent Claim
8 words
The peptide of claim 1 which is ##STR6##
Claim 4
Dependent Claim
8 words
The peptide of claim 1 which is ##STR7##
Claim 5
Dependent Claim
14 words
A peptide having the formula cyclo-(ARG-LYS-ASP-VAL-TYR) or a pharmaceutically-acceptable acid- or base-addition salt thereof.
Claim 6
Dependent Claim
14 words
A peptide having the formula cyclo-(ARG-LYS-ASP-VAL-TYR) or a pharmaceutically-acceptable acid- or base-addition salt thereof.
Claim 7
Dependent Claim
14 words
A peptide having the formula cyclo-(ARG-LYS-ASP-VAL-TYR-GLY) or a pharmaceutically-acceptable acid- or base-addition salt thereof.
Claim 8
Dependent Claim
14 words
A peptide having the formula cyclo-(ARG-LYS-ASP-VAL-TYR-GLY) or a pharmaceutically-acceptable acid- or base-addition salt thereof.
Claim 9
Dependent Claim
14 words
A peptide having the formula H-ARG-cyclo-(LYS-ASP)-VAL-TYR-OH or a pharmaceutically-acceptable acid- or base-addition salt thereof.
Claim 10
Dependent Claim
14 words
A peptide having the formula H-ARG-cyclo-(LYS-ASP)-VAL-TYR-OH or a pharmaceutically-acceptable acid- or base-addition salt thereof.
Claim 11
Dependent Claim
23 words
A pharmaceutical composition comprising an effective T cell inducing amount of a peptide of claim 1 in admixture with a pharmaceutically acceptable carrier.
Claim 12
Dependent Claim
37 words
A method for treatment of a condition resulting from relative or absolute T cell deficiency in a subject having such a condition which comprises administering to the subject a therapeutically-effective amount of a peptide of claim 1.
Claim 13
Dependent Claim
33 words
A method for inducing lymphopoietic stem cells of a subject to develop the characteristics of thymus-derived lymphocytes which comprises administering to the subject an effective inducing amount of a peptide of claim 1.
References Cited (Backward Citations)
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Cited
US4002740A
Cited
US4190646A
Cited
US4420424A
Cited
US4261886A
Cited
US4361673A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-10-14 | 1989-04-15 | 1989-10-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-10-14 | 1993-04-15 | 1993-10-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-10-14 | 1997-04-15 | 1997-10-15 | $7700.00 | Window Closed / Lapsed |