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US5077215A
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Neutralized perfluoro-3,6-dioxa-4-methyl-7-octene sulphonyl fluoride copolymer surface for attachment and growth of animal cells
Assignee: Commonwealth Scientific and Industrial Research Organisation
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Filing: 1988-09-19
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Granted: 1991-12-31
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Expires: 2008-09-19
Abstract
Abstract PCT No. PCT/AU88/00368 Sec. 371 Date Jul. 17, 1989 Sec. 102(e) Date Jul. 17, 1989 PCT Filed Sep. 19, 1988 PCT Pub. No. WO89/02457 PCT Pub. Date Mar. 23, 1989.Neutralized surface of a polymer of perfluoro-3,6-dioxa-4-methyl-7-octene sulphonyl fluoride for attachment and growth of animal cells in vivo or in vitro, the comonomer preferably being tetrfluorethylene.
Inventors
- 👤 Brian R. McAuslan
- 👤 John G. Steele
- 👤 William Norris
- 👤 Graham Johnson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 18:44
CPC Classifications
C; C12; C12N; C12N5/00; C12N5/0068; C12N2533/00; C12N2533/30; Y; Y10; Y10S; Y10S623/00; Y10S623/915; Y10S623/92
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
31 words
In a prosthesis or sponge implantable in a body, the improvement comprising forming the surface of said prosthesis or sponge from a neutralized copolymer of perfluoro-3,6-dioxa-4-methyl-7-octene sulphonyl fluoride and a monomer.
Claim 2
Dependent Claim
31 words
In a prosthesis or sponge implantable in a body, the improvement comprising forming the surface of said prosthesis or sponge from a neutralized copolymer of perfluoro-3,6-dioxa-4-methyl-7-octene sulphonyl fluoride and a monomer.
Claim 3
Dependent Claim
12 words
The prosthesis or sponge of claim 1 wherein the monomer is tetrafluoroethylene.
Claim 4
Dependent Claim
18 words
The prosthesis or sponge of claim 1 further comprising a supporting material to which said copolymer is applied.
Claim 5
Dependent Claim
26 words
The prosthesis or sponge of claim 3 wherein said supporting material is selected from the group consisting of a polymer, ceramic, metal, glass and preformed membrane.
Claim 6
Dependent Claim
14 words
The prosthesis or sponge of claim 4 wherein said polymer is a porous polymer.
Claim 7
Dependent Claim
16 words
The prosthesis or sponge of claim 5 wherein said porous polymer is polytetrafluoroethylene or expanded polytetrafluoroethylene.
Claim 8
Dependent Claim
16 words
The prosthesis or sponge of claim 5 wherein the porous polymer is knitted or woven polyester.
Claim 9
Dependent Claim
13 words
The prosthesis or sponge of claim 5 wherein the porous polymer is polyurethane.
Claim 10
Dependent Claim
13 words
The prosthesis of sponge of claim 1 in the form of a tube.
Claim 11
Dependent Claim
15 words
The prosthesis or sponge of claim 1 wherein the surface further comprises adsorbed adhesive proteins.
Claim 12
Dependent Claim
15 words
The prosthesis or sponge of claim 10 wherein said adhesive proteins are derived from serum.
Claim 13
Dependent Claim
30 words
The prosthesis or sponge of claim 11 wherein said adhesive serum proteins are selected from the group consisting of fibronectin, vitronectin, thrombospondin and adhesive fragments of any of these proteins.
Claim 14
Dependent Claim
16 words
The prosthesis or sponge of claim 1 wherein the surface further comprises animal cells adhered thereto.
Claim 15
Dependent Claim
32 words
A surface for the attachment and growth of animal cells in vivo, said surface comprising the neutralized form of a copolymer of perfluoro-3,6-dioxa-4-methyl-7-octene sulphonyl fluoride and monomer with animal cells adhered thereto.
Claim 16
Dependent Claim
32 words
A surface for the attachment and growth of animal cells in vivo, said surface comprising the neutralized form of a copolymer of perfluoro-3,6-dioxa-4-methyl-7-octene sulphonyl fluoride and monomer with animal cells adhered thereto.
Claim 17
Dependent Claim
47 words
A process for the preparation of a surface for the attachment and growth of animal cells in vivo, said process comprising applying a copolymer of perfluoro-3-, 6-dioxa-4-methyl-7-octene sulphonyl fluoride and a monomer to an appropriate substrate, neutralizing the resultant surface and adhering animal cells to the surface.
Claim 18
Dependent Claim
47 words
A process for the preparation of a surface for the attachment and growth of animal cells in vivo, said process comprising applying a copolymer of perfluoro-3-, 6-dioxa-4-methyl-7-octene sulphonyl fluoride and a monomer to an appropriate substrate, neutralizing the resultant surface and adhering animal cells to the surface.
Claim 19
Dependent Claim
36 words
A process for the attachment and growth of animal cells in vivo comprising: exposing animal cells to a prosthesis or sponge having a surface formed from a neutralized copolymer of perfluoro-3,6-dioxa-4-methyl-7-octene sulphonyl fluoride and a monomer.
Claim 20
Dependent Claim
36 words
A process for the attachment and growth of animal cells in vivo comprising: exposing animal cells to a prosthesis or sponge having a surface formed from a neutralized copolymer of perfluoro-3,6-dioxa-4-methyl-7-octene sulphonyl fluoride and a monomer.
Claim 21
Dependent Claim
33 words
A process for the attachment and growth of animal cells in vitro comprising: exposing animal cells in vitro to a surface formed from a neutralized copolymer of perfluoro-3,6-dioxa-4-methyl-7-octene sulphonyl fluoride and a monomer.
Claim 22
Dependent Claim
33 words
A process for the attachment and growth of animal cells in vitro comprising: exposing animal cells in vitro to a surface formed from a neutralized copolymer of perfluoro-3,6-dioxa-4-methyl-7-octene sulphonyl fluoride and a monomer.
Claim 23
Dependent Claim
20 words
The process of claim 17 which further comprises exposing said surface to a medium containing animal cells and adhesive proteins.
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1994-12-30 | 1995-07-01 | 1995-12-31 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-12-30 | 1999-07-01 | 1999-12-31 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-12-30 | 2003-07-01 | 2003-12-31 | $7700.00 | Window Closed / Lapsed |