US5075333A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Tetrahydronaphthalene and indane compounds useful for reversing the photo-damage in sun-exposed skin
Assignee: Hoffmann La Roche Inc
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Filing: 1990-05-08
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Granted: 1991-12-24
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Expires: 2010-05-08
Abstract
Abstract The use of compounds of formula I as topical agents to combat the disorders of the skin produced by photodamage which disorders include: wrinkling, elastosis and premature aging is described. Compounds of formula I are <IMAGE> I wherein n represents 1 or 2, Z represents-SR, wherein R represents lower-alkyl, lower-alkenyl, lower-alkynyl, lower-alkoxy-lower-alkyl, lower-alkanoyl-lower-alkyl, hydroxy-lower-alkyl, halo-lower-alkyl, lower-carbalkoxy-lower alkyl, mono-lower-alkylamino, di-lower-alkylamino, mono-lower-alkylamido, or di-lower-alkylamido and pharmaceutically acceptable salts thereof.
Inventors
- 👤 Graeme F. Bryce
- 👤 Stanley S. Shapiro
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 22:21
CPC Classifications
C; C07; C07C; C07C333/00; C07C333/02; C07C333/04; A; A61; A61K; A61K31/00; A61K31/095; A61K31/10; A61K31/21; A61K31/255; A61K8/00; A61K8/18; A61K8/30; A61K8/46; A61K8/67; A61K8/671; A61Q; A61Q19/00; A61Q19/08
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
84 words
A method of treating the conditions associated with photodamaged skin comprising topically administering a compound of the formula ##STR4## wherein n represents 1 or 2; Z represents --SR wherein R represents lower-alkyl, lower-alkenyl, lower-alkynyl lower-alkoxy-lower-alkyl, lower-alkanoyl-lower-alkyl, hydroxy-lower-alkyl, halo-lower-alkyl, lower-carbalkoxy-lower-alkyl, mono-lower-alkylamino, di-lower-alkylamino, mono-lower-alkylamido or di-lower-alkylamido, or a pharmaceutically acceptable salt thereof to an area of the skin in need of said treatment, said compound of formula I being applied to said area in an amount effective to reverse the effects of photodamage in said area.
Claim 2
Independent Claim
84 words
A method of treating the conditions associated with photodamaged skin comprising topically administering a compound of the formula ##STR4## wherein n represents 1 or 2; Z represents --SR wherein R represents lower-alkyl, lower-alkenyl, lower-alkynyl lower-alkoxy-lower-alkyl, lower-alkanoyl-lower-alkyl, hydroxy-lower-alkyl, halo-lower-alkyl, lower-carbalkoxy-lower-alkyl, mono-lower-alkylamino, di-lower-alkylamino, mono-lower-alkylamido or di-lower-alkylamido, or a pharmaceutically acceptable salt thereof to an area of the skin in need of said treatment, said compound of formula I being applied to said area in an amount effective to reverse the effects of photodamage in said area.
Claim 3
Dependent Claim
11 words
A method according to claim 1 wherein R is lower alkyl.
Claim 4
Dependent Claim
15 words
A method according to claim 2 wherein the compound of formula I is ethyl p-[2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)propenyl]phenylsulfide.
Claim 5
Dependent Claim
15 words
A method according to claim 2 wherein the compound of formula I is methyl p-[2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)propenyl]phenylsulfide.
Claim 6
Dependent Claim
14 words
A method according to claim 1 wherein the compound of formula I is S-[p-[2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)propenyl]phenyl]dimethylthiocarbamate.
Claim 7
Dependent Claim
35 words
The method of claim 1 wherein the compound of formula I is administered in a topical composition containing at least 0.00001% by weight of said compound of formula I and an inert dermatologically acceptable carrier.
Claim 8
Dependent Claim
30 words
The method of claim 6, wherein said topical composition contains a compound of formula I in an amount of from about 0.00001% to about 1.0% by weight of the composition.
Claim 9
Dependent Claim
29 words
The method of claim 7, wherein said topical composition contains a compound of formula I in amount of from about 0.0001 to about 0.1% by weight of the composition.
Claim 10
Dependent Claim
13 words
The method of claim 6, wherein said composition contains a cosmetically active ingredient.
Claim 11
Dependent Claim
13 words
The method of claim 9 wherein said cosmetically active ingredient is a sunscreen.
Claim 12
Dependent Claim
13 words
The method of claim 6, wherein said composition is a cream or ointment.
Claim 13
Dependent Claim
13 words
The method of claim 11, wherein said composition is applied to the face.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-12-23 | 1995-06-24 | 1995-12-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-12-23 | 1999-06-24 | 1999-12-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-12-23 | 2003-06-24 | 2003-12-24 | $7700.00 | Window Closed / Lapsed |