US4396553A
Expired / Lapsed
US
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Tetrahydronaphthalene and indane compounds useful as anti-tumor agents
Assignee: F Hoffmann La Roche AG
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Filing: 1982-02-04
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Granted: 1983-08-02
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Expires: 2002-02-04
Abstract
Abstract This invention is directed to tetrahydronaphthalene and indane compounds and processes thereto. These compounds are useful as tumor inhibiting agents, in the treatment of neoplasms and dermatological conditions.
Inventors
- 👤 Michael Klaus
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 10:55
CPC Classifications
C; C07; C07C; C07C321/00; C07C17/00; C07C17/26; C07C17/263; C07C17/2635; C07C309/00; C07C317/00
Claims Analysis
Total Claims: 26
Claim 1
Independent Claim
55 words
Compounds of the formula ##STR8## wherein n represents 1 or 2; Z represents mercapto or --S(O) m R, wherein m represents 0, 1 or 2; R represents lower-alkyl, lower-alkenyl, lower-alkoxy-lower-alkyl, lower-alkanoyl-lower-alkyl, hydroxy-lower-alkyl, halo-lower-alkyl, lower-carbalkoxy-lower-alkyl or, when m is 1 or 2, R represents also lower-alkoxy, hydroxy, mono-lower-alkyl amino or di-lower-alkylamino, and pharmaceutically acceptable salts thereof.
Claim 2
Dependent Claim
55 words
Compounds of the formula ##STR8## wherein n represents 1 or 2; Z represents mercapto or --S(O) m R, wherein m represents 0, 1 or 2; R represents lower-alkyl, lower-alkenyl, lower-alkoxy-lower-alkyl, lower-alkanoyl-lower-alkyl, hydroxy-lower-alkyl, halo-lower-alkyl, lower-carbalkoxy-lower-alkyl or, when m is 1 or 2, R represents also lower-alkoxy, hydroxy, mono-lower-alkyl amino or di-lower-alkylamino, and pharmaceutically acceptable salts thereof.
Claim 3
Dependent Claim
24 words
Compounds according to claim 1 wherein n is 2, m is 0 and R is selected from the group consisting of methyl and ethyl.
Claim 4
Dependent Claim
10 words
A compound according to claim 2 which is methyl p-[2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)propenyl]phenylsulphide.
Claim 5
Dependent Claim
10 words
A compound according to claim 2 which is ethyl p-[2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)propenyl]phenylsulphide.
Claim 6
Dependent Claim
24 words
Compounds according to claim 1 wherein n is 2, m is 1 and R is selected from the group consisting of methyl and ethyl.
Claim 7
Dependent Claim
10 words
A compound according to claim 5 which is methyl p-[2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)propenyl]phenylsulphoxide.
Claim 8
Dependent Claim
10 words
A compound according to claim 5 which is ethyl p-[2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)propenyl]phenylsuphhoxide.
Claim 9
Dependent Claim
37 words
A compound according to claim 1 wherein n is 2, m is 2 and R is selected from the group consisting of methyl, ethyl, propyl, isopropyl, methylpropyl, chloroethyl, allyl, vinyl, trifluoroethyl, ethoxy, acetyl, hydroxyethyl, hydroxy and ethylamino.
Claim 10
Dependent Claim
9 words
A compound according to claim 8 which is N-ethyl-p-[2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)propenyl]benzenesulphonamide.
Claim 11
Dependent Claim
10 words
A compound according to claim 8 which is ethyl p-[2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)propenyl]benzenesulphinate.
Claim 12
Dependent Claim
10 words
A compound according to claim 8 which is ethyl p-[2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)propenyl]phenylsulphone.
Claim 13
Dependent Claim
10 words
A compound according to claim 8 which is methyl p-[2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)propenyl]phenylsulphone.
Claim 14
Dependent Claim
10 words
A compound according to claim 8 which is allyl p-[2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)propenyl]-phenylsulphone.
Claim 15
Dependent Claim
10 words
A compound according to claim 8 which is 2,2,2-trifluoroethyl p-[2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)propenyl]phenylsulphone.
Claim 16
Dependent Claim
10 words
A compound according to claim 8 which is propyl p-[2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)propenyl]phenylsulphone.
Claim 17
Dependent Claim
10 words
A compound according to claim 8 which is isopropyl p-[2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)propenyl]phenylsulphone.
Claim 18
Dependent Claim
10 words
A compound according to claim 8 which is 1-methylpropyl p-[2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)propenyl]phenylsulphone.
Claim 19
Dependent Claim
9 words
A compound according to claim 8 which is 2-[[p-[2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)propenyl]phenyl]sulphonyl]-ethanol.
Claim 20
Dependent Claim
10 words
A compound according to claim 8 which is vinyl p-[2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)propenyl]phenylsulphone.
Claim 21
Dependent Claim
10 words
A compound according to claim 8 which is 2-chloroethyl p-[2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)propenyl]phenylsulphone.
Claim 22
Dependent Claim
9 words
A compound according to claim 8 which is ethyl[[p-[2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)propenyl]phenyl]sulphonyl]acetate.
Claim 23
Dependent Claim
10 words
A compound according to claim 8 which is p-[2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)propenyl]benzenesulphonic acid.
Claim 24
Dependent Claim
14 words
Compounds according to claim 1 which are salts of sulphonic acids or sulphinic acids.
Claim 25
Dependent Claim
10 words
A compound according to claim 23 which is sodium p-[2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)propenyl]benzenesulphinate.
Claim 26
Dependent Claim
10 words
A compound according to claim 23 which is sodium p-[2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)propenyl]benzenesulphonate.
References Cited (Backward Citations)
US424A
Cited
US4038323A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-08-01 | 1987-01-31 | 1987-08-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-08-01 | 1991-01-31 | 1991-08-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-08-01 | 1995-01-31 | 1995-08-02 | $7700.00 | Window Closed / Lapsed |