Methods for treatment of sundamaged human skin with retinoids

Claim 1

A method for retarding and reversing the loss of collagen fibers, abnormal changes in elastic fibers, and deterioration of small blood vessels in sundamaged human skin, comprising applying topically to the surface of the skin a composition comprising effective amounts of a retinoid selected from the group consisting of 2-(4-Carboxybenzamido)-5,6,7,8-tetrahydro-5,5,8,8-tetramethylphaphthalene; 2-[N-(4-Carboxyphenyl)carbamoly]-5,6,7,8-tetrahydro-5,5,8,8-tetramethyll-naphthalene; 1-[3,5-(Di-tert-butyl)benzoyl]-2-(4-Carboxyphenyl)ethene; TTNT 2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-6-benzo (b) thiophene carboxylic acid; TTNF 2-(t,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-6-benzo (b) furancarboxylic acid; TTNI 2-(5,6,7,8-tetraphydro-5,5,8,8-tetramethyl-2-naphthyl)-6-indolecarboxylic acid; TTNN 2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2naphthyl)-6-naphthalene carboxylic acid; p-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-anthracenyl) benzonic acid; and esters or amides of 13 trans retinoic acid or 13-cis retinoic acid wherein the --OH group of the carboxylic acid (--COOH) group is substituted by --OR 1 or NR 2 R 3 , wherein R 1 , R 2 and R 3 are such that these esters or amides can be converted to 13-trans retinoic acid or 13-cis retinoic acid through hydrolysis, metabolism, or cleavage, in a non-toxic, dermatologically acceptable vehicle in a program of maintenance therapy, whereby the skin substantially regains and maintains its firmness, turgor and elasticity during said therapy, said composition and amounts of retinoid therein being selected so as to provide a dose for application which is insufficient to cause excessive irritation.

Claim 2

A method for retarding and reversing the loss of collagen fibers, abnormal changes in elastic fibers, and deterioration of small blood vessels in sundamaged human skin, comprising applying topically to the surface of the skin a composition comprising effective amounts of a retinoid selected from the group consisting of 2-(4-Carboxybenzamido)-5,6,7,8-tetrahydro-5,5,8,8-tetramethylphaphthalene; 2-[N-(4-Carboxyphenyl)carbamoly]-5,6,7,8-tetrahydro-5,5,8,8-tetramethyll-naphthalene; 1-[3,5-(Di-tert-butyl)benzoyl]-2-(4-Carboxyphenyl)ethene; TTNT 2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-6-benzo (b) thiophene carboxylic acid; TTNF 2-(t,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-6-benzo (b) furancarboxylic acid; TTNI 2-(5,6,7,8-tetraphydro-5,5,8,8-tetramethyl-2-naphthyl)-6-indolecarboxylic acid; TTNN 2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2naphthyl)-6-naphthalene carboxylic acid; p-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-anthracenyl) benzonic acid; and esters or amides of 13 trans retinoic acid or 13-cis retinoic acid wherein the --OH group of the carboxylic acid (--COOH) group is substituted by --OR 1 or NR 2 R 3 , wherein R 1 , R 2 and R 3 are such that these esters or amides can be converted to 13-trans retinoic acid or 13-cis retinoic acid through hydrolysis, metabolism, or cleavage, in a non-toxic, dermatologically acceptable vehicle in a program of maintenance therapy, whereby the skin substantially regains and maintains its firmness, turgor and elasticity during said therapy, said composition and amounts of retinoid therein being selected so as to provide a dose for application which is insufficient to cause excessive irritation.