US3856934A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Skin depigmentation
Assignee: Individual
•
Filing: 1973-01-22
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Granted: 1974-12-24
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Expires: 1993-01-22
Abstract
Abstract The specification discloses that synergistic compositions for depigmentation by topical application have been found which comprise a mixture of hydroquinone, retinoic acid and a corticosteroid formulated in a pharmaceutically-cosmetically acceptable vehicle. An illustrative composition comprising from about 2 percent to about 5 percent hydroquinone, from about 0.05 percent to about 0.1 percent retinoic acid and from about 0.05 percent to about 0.1 percent dexamethasone was particularly effective.
Inventors
- 👤 A Kligman
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 21:55
CPC Classifications
A; A61; A61K; A61K8/00; A61K8/18; A61K8/30; A61K8/33; A61K8/36; A61K8/361; A61K8/34; A61K8/347; A61K8/368; A61K8/37; A61K8/40; A61K8/41; A61K8/46; A61K8/463; A61K8/466; A61K8/63; A61K8/67; A61K8/671; A61K8/69; A61K8/72; A61K8/84; A61K8/86; A61Q; A61Q19/00; A61Q19/02
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
22 words
A SKIN DEPIGMENTING COMPOSITION FOR TOPICAL APPLICATION TO THE SKIN COMPRISING A MELANIN INHIBITING AMOUNT OF HYDROQUINONE, RETINOIC ACID AND A CORTICOSTEROID.
Claim 2
Dependent Claim
22 words
A SKIN DEPIGMENTING COMPOSITION FOR TOPICAL APPLICATION TO THE SKIN COMPRISING A MELANIN INHIBITING AMOUNT OF HYDROQUINONE, RETINOIC ACID AND A CORTICOSTEROID.
Claim 3
Dependent Claim
29 words
A composition according to claim 1 comprising a melanin inhibiting amount of hydroquinone, retinoic acid, and a corticosteroid selected from the group consisting of dexamethasone, hydrocortisone, hydrocortisone-17-valerate, and progesterone.
Claim 4
Dependent Claim
45 words
The composition of claim 2 consisting essentially of from about 2 to about 5 weight percent hydroquinone, from about 0.05 to about 0.1 weight percent retinoic acid, and from about 0.05 to about 0.1 weight percent dexamethasone in a pharmaceutically acceptable vehicle for topical application.
Claim 5
Dependent Claim
46 words
A composition according to claim 2 consisting essentially of from about 2 to about 5 weight percent hydroquinone, from about 0.05 to about 0.1 weight percent hydrocortisone-17-valerate, and from about 0.05 to about 0.1 weight percent retinoic acid in a pharmaceutically acceptable vehicle for topical application.
Claim 6
Independent Claim
28 words
A method for inhibiting the production of melanin which comprises topical application of a composition comprising hydroquinone, retinoic acid, and a corticosteroid, in amounts sufficient to cause depigmentation.
Claim 7
Independent Claim
28 words
A method for inhibiting the production of melanin which comprises topical application of a composition comprising hydroquinone, retinoic acid, and a corticosteroid, in amounts sufficient to cause depigmentation.
Claim 8
Dependent Claim
16 words
The method of claim 5 wherein said composition consists essentially of hydroquinone, retinoic acid, and dexamethasone.
Claim 9
Dependent Claim
62 words
A method according to claim 5 which comprises topical application to pigmented skin of a composition comprising from about 2 to about 5 weight percent hydroquinone, from about 0.05 to about 0.1 weight percent retinoic acid, and from about 0.05 to about 0.1 weight percent hydrocortisone-17-valerate in a pharmaceutically acceptable vehicle for Topical application and continuing such application until depigmentation is achieved.
Claim 10
Dependent Claim
54 words
A method according to claim 5 which comprises topical application to pigmented skin of a composition comprising from about 2 to about 5 weight percent hydroquinone, from about 0.05 to about 0.1 weight percent retinoic acid, and from about 0.05 to about 0.1 weight percent dexamethasone in a pharmaceutically acceptable vehicle for topical application.
References Cited (Backward Citations)
US3006939A
Cited
US3060097A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1977-12-23 | 1978-06-24 | 1978-12-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1981-12-23 | 1982-06-24 | 1982-12-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1985-12-23 | 1986-06-24 | 1986-12-24 | $7700.00 | Window Closed / Lapsed |