US5061475A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Composition and method of treatment of arthritis and related diseases with holmium-166 radionuclides
Assignee: CADEMA MEDICAL PRODUCTS Inc A CORP OF
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Filing: 1989-06-28
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Granted: 1991-10-29
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Expires: 2009-06-28
Abstract
Abstract An aggregate suspension containing holmium-166 hydroxide and a carrier (such as a particulate ferric hydroxide) is injected into a patient's anesthetized joint (such as a knee joint or hip joint) for the treatment of inflamed synovial tissues such as present in arthritis, especially rheumatoid arthritis. The aggregate suspension is in a range of particle sizes from 1 to 40 microns. The holmium-166-containing suspension treats the synovial tissues, whereby radiation synovectomy takes place.
Inventors
- 👤 Ephraim Lieberman
- 👤 Maurice E. Bordoni
- 👤 Alfred K. Thornton
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 03:08
CPC Classifications
A; A61; A61K; A61K51/00; A61K51/12; A61K51/1217; A61K2121/00
Claims Analysis
Total Claims: 67
Claim 1
Independent Claim
26 words
A radioactive composition for the treatment of arthritis comprising a suspension containing particles having a minimum size of one micron, said suspension including particles containing holmium-166.
Claim 2
Dependent Claim
26 words
A radioactive composition for the treatment of arthritis comprising a suspension containing particles having a minimum size of one micron, said suspension including particles containing holmium-166.
Claim 3
Dependent Claim
30 words
A radioactive composition for the treatment of arthritis comprising a suspension containing particles having a minimum size of one micron, said suspension including particles containing holmium-166 and a particulate carrier.
Claim 4
Dependent Claim
30 words
A radioactive composition for the treatment of arthritis comprising a suspension containing particles having a minimum size of one micron, said suspension including particles containing holmium-166 and a particulate carrier.
Claim 5
Dependent Claim
14 words
The radioactive composition described in claim 2 wherein said particulate carrier includes ferric hydroxide.
Claim 6
Dependent Claim
14 words
The radioactive composition described in claim 2 wherein said particulate carrier includes aluminum hydroxide.
Claim 7
Dependent Claim
37 words
A radioactive composition for the treatment of rheumatoid arthritis comprising a suspension containing particles having a minimum size of one micron, said suspension including particles containing holmium-166 in an amount effective for the treatment of rheumatoid arthritis.
Claim 8
Dependent Claim
37 words
A radioactive composition for the treatment of rheumatoid arthritis comprising a suspension containing particles having a minimum size of one micron, said suspension including particles containing holmium-166 in an amount effective for the treatment of rheumatoid arthritis.
Claim 9
Dependent Claim
41 words
A radioactive composition for the treatment of rheumatoid arthritis comprising a suspension containing particles having a minimum size of one micron, said suspension including particles containing holmium-166 in an amount effective for the treatment of rheumatoid arthritis and a particulate carrier.
Claim 10
Dependent Claim
41 words
A radioactive composition for the treatment of rheumatoid arthritis comprising a suspension containing particles having a minimum size of one micron, said suspension including particles containing holmium-166 in an amount effective for the treatment of rheumatoid arthritis and a particulate carrier.
Claim 11
Dependent Claim
36 words
A composition for the treatment of inflamed synovial tissues including particles having a minimum size of one micron, the particles containing holmium-166 and a carrier suitable for injection at the site of the inflamed synovial tissues.
Claim 12
Dependent Claim
36 words
A composition for the treatment of inflamed synovial tissues including particles having a minimum size of one micron, the particles containing holmium-166 and a carrier suitable for injection at the site of the inflamed synovial tissues.
Claim 13
Dependent Claim
14 words
The radioactive composition described in claim 7 wherein said carrier includes a metallic hydroxide.
Claim 14
Dependent Claim
31 words
The radioactive composition described in claim 7 wherein said carrier includes a metallic hydroxide selected from the group consisting of bismuth hydroxide, chromium hydroxide, cupric hydroxide, manganese hydroxide, and stannous hydroxide.
Claim 15
Dependent Claim
13 words
The radioactive composition described in claim 7 wherein said carrier includes ferric hydroxide.
Claim 16
Dependent Claim
13 words
The radioactive composition described in claim 7 wherein said carrier includes aluminum hydroxide.
Claim 17
Independent Claim
43 words
A method of conducting radiation synovectomy including the step of injecting a composition into a patient in the vicinity of synovial tissues to be treated, wherein the injected composition contains particles which include holmium-166 said particles having a minimum size of one micron.
Claim 18
Independent Claim
43 words
A method of conducting radiation synovectomy including the step of injecting a composition into a patient in the vicinity of synovial tissues to be treated, wherein the injected composition contains particles which include holmium-166 said particles having a minimum size of one micron.
Claim 19
Dependent Claim
20 words
The method described in claim 12 wherein the injected composition contains a suspension of particles including holmium-166 and a carrier.
Claim 20
Dependent Claim
22 words
The method described in claim 12 wherein the injected composition contains a suspension of particles including holmiun-166 and a metallic hydroxide carrier.
Claim 21
Dependent Claim
29 words
The method described in claim 14 wherein said metallic hydroxide carrier is selected from the group consisting of bismuth hydroxide, chromium hydroxide, cupric hydroxide, manganese hydroxide, and stannous hydroxide.
Claim 22
Dependent Claim
22 words
The method described in claim 12 wherein the injected composition contains a suspension of particles including holmium-166 and a monoclonal antibody carrier.
Claim 23
Independent Claim
120 words
A method for the localized treatment of synovial tissue of a joint, comprising the steps of: preparing an aggregated suspension containing particles, the particles having a minimum size of one micron, including particles containing holmium-166; obtaining a solution of a local anesthetic; placing the holmium-166 containing suspension in a needle assembly; treating the skin surrounding the joint with an antiseptic; instilling the anesthetic solution in the skin and the subcutaneous tissues surrounding the joint; injecting the holmium-166-containing suspension into the joint near the synovial tissues thereof; moving the joint through a flexion-extension arc; and immobilizing the joint in full extension for a predetermined period of time to permit treatment of the synovial tissues, by the holmium-166-containing suspension, to take place.
Claim 24
Independent Claim
120 words
A method for the localized treatment of synovial tissue of a joint, comprising the steps of: preparing an aggregated suspension containing particles, the particles having a minimum size of one micron, including particles containing holmium-166; obtaining a solution of a local anesthetic; placing the holmium-166 containing suspension in a needle assembly; treating the skin surrounding the joint with an antiseptic; instilling the anesthetic solution in the skin and the subcutaneous tissues surrounding the joint; injecting the holmium-166-containing suspension into the joint near the synovial tissues thereof; moving the joint through a flexion-extension arc; and immobilizing the joint in full extension for a predetermined period of time to permit treatment of the synovial tissues, by the holmium-166-containing suspension, to take place.
Claim 25
Independent Claim
39 words
A method for the treatment of synovial tissue of a joint comprising injecting, to the joint, a therapeutically effective quantity of an aggregated suspension containing particles, the particles having a minimum size of one micron, including particles containing holmium-166.
Claim 26
Independent Claim
39 words
A method for the treatment of synovial tissue of a joint comprising injecting, to the joint, a therapeutically effective quantity of an aggregated suspension containing particles, the particles having a minimum size of one micron, including particles containing holmium-166.
Claim 27
Independent Claim
155 words
A method for the localized treatment of synovial tissue of a joint, comprising the steps of: preparing an aggregated suspension containing particles, the particles having a minimum size of one micron, including particles containing holmium-166; obtaining a solution of a local anesthetic; placing the holmium-166-containing suspension in a needle assembly which includes a needle, a needle tract, and a three-way stopcock; treating the skin surrounding the joint with an antiseptic; instilling the anesthetic solution in the skin and the subcutaneous tissues surrounding the joint; injecting the holmium-166 containing suspension into the joint near the synovial tissues thereof; cleansing the needle and needle tract by flushing with the anesthetic solution through the stopcock assembly as the needle is withdrawn from the patient; moving the joint through a flexion-extension arc; and immobilizing the joint in full extension for a predetermined period of time to permit treatment of the synovial tissues by the holium-166-containing suspension to take place.
Claim 28
Independent Claim
155 words
A method for the localized treatment of synovial tissue of a joint, comprising the steps of: preparing an aggregated suspension containing particles, the particles having a minimum size of one micron, including particles containing holmium-166; obtaining a solution of a local anesthetic; placing the holmium-166-containing suspension in a needle assembly which includes a needle, a needle tract, and a three-way stopcock; treating the skin surrounding the joint with an antiseptic; instilling the anesthetic solution in the skin and the subcutaneous tissues surrounding the joint; injecting the holmium-166 containing suspension into the joint near the synovial tissues thereof; cleansing the needle and needle tract by flushing with the anesthetic solution through the stopcock assembly as the needle is withdrawn from the patient; moving the joint through a flexion-extension arc; and immobilizing the joint in full extension for a predetermined period of time to permit treatment of the synovial tissues by the holium-166-containing suspension to take place.
Claim 29
Independent Claim
118 words
A method for the localized treatment of an arthritic joint, comprising the steps of: preparing an aggregated suspension containing particles, the particles having a minimum size of one micron, including particles containing holmium-166; obtaining a solution of a local anesthetic; placing the holmium-166-containing suspension in a needle assembly; treating the skin surrounding the joint with an antiseptic; installing the anesthetic solution in the skin and the subcutaneous tissues surrounding the joint; injecting the holmium 166-containing suspension into the joint near the synovial tissues thereof; moving the joint through a flexion-extension arc; and immobilizing the joint in full extension for a predetermined period of time to permit treatment of the arthritic joint by the holmium-166-containing suspension to take place.
Claim 30
Independent Claim
118 words
A method for the localized treatment of an arthritic joint, comprising the steps of: preparing an aggregated suspension containing particles, the particles having a minimum size of one micron, including particles containing holmium-166; obtaining a solution of a local anesthetic; placing the holmium-166-containing suspension in a needle assembly; treating the skin surrounding the joint with an antiseptic; installing the anesthetic solution in the skin and the subcutaneous tissues surrounding the joint; injecting the holmium 166-containing suspension into the joint near the synovial tissues thereof; moving the joint through a flexion-extension arc; and immobilizing the joint in full extension for a predetermined period of time to permit treatment of the arthritic joint by the holmium-166-containing suspension to take place.
Claim 31
Independent Claim
38 words
A method for the treatment of an arthritic joint comprising injecting, to the joint, a therapeutically effective quantity of an aggregated suspension containing particles, the particles having a minimum particle size of one micron, including particles containing holmium-166.
Claim 32
Independent Claim
38 words
A method for the treatment of an arthritic joint comprising injecting, to the joint, a therapeutically effective quantity of an aggregated suspension containing particles, the particles having a minimum particle size of one micron, including particles containing holmium-166.
Claim 33
Dependent Claim
42 words
A radioactive composition for use in treating inflamed synovial tissues comprising an injectable suspension containing particles having a minimum size of one micron, said suspension including particles containing holmium-166, said composition suitable for injection at the site of the inflamed synovial tissues.
Claim 34
Dependent Claim
42 words
A radioactive composition for use in treating inflamed synovial tissues comprising an injectable suspension containing particles having a minimum size of one micron, said suspension including particles containing holmium-166, said composition suitable for injection at the site of the inflamed synovial tissues.
Claim 35
Dependent Claim
17 words
The radioactive composition described in claim 22, further including a carrier compatible with the tissues undergoing treatment.
Claim 36
Dependent Claim
14 words
The radioactive composition described in claim 22 wherein said carrier is a metallic hydroxide.
Claim 37
Dependent Claim
14 words
The radioactive composition described in claim 22 wherein said carrier is a monoclonal antibody.
Claim 38
Dependent Claim
30 words
A radioactive composition for the treatment of arthritis comprising a particulate aggregate containing particles having a minimum size of one micron, said particulate aggregate including particles of particles containing holmium-166.
Claim 39
Dependent Claim
30 words
A radioactive composition for the treatment of arthritis comprising a particulate aggregate containing particles having a minimum size of one micron, said particulate aggregate including particles of particles containing holmium-166.
Claim 40
Dependent Claim
35 words
A radioactive composition for the treatment of arthritis comprising of a particulate aggregate containing particles having a minimum size of one micron, said particulate aggregate including particles of particles containing holmium-166 and a particulate carrier.
Claim 41
Dependent Claim
35 words
A radioactive composition for the treatment of arthritis comprising of a particulate aggregate containing particles having a minimum size of one micron, said particulate aggregate including particles of particles containing holmium-166 and a particulate carrier.
Claim 42
Dependent Claim
14 words
The radioactive composition described in claim 29 wherein said particulate carrier includes ferric hydroxide.
Claim 43
Dependent Claim
14 words
The radioactive composition described in claim 27 wherein said particulate carrier includes aluminum hydroxide.
Claim 44
Dependent Claim
38 words
A radioactive composition for the treatment of rheumatoid arthritis comprising a particulate aggregate containing particles having a minimum size of one micron, said particulate aggregate including particles containing holmium-166 in an amount effective for the treatment rheumatoid arthritis.
Claim 45
Dependent Claim
38 words
A radioactive composition for the treatment of rheumatoid arthritis comprising a particulate aggregate containing particles having a minimum size of one micron, said particulate aggregate including particles containing holmium-166 in an amount effective for the treatment rheumatoid arthritis.
Claim 46
Dependent Claim
43 words
A radioactive composition for the treatment of rheumatoid arthritis comprising a particulate aggregate containing particles having a minimum size of one micron, said particulate aggregate including particles containing holmium-166 in an amount effective for the treatment of rheumatoid arthritis and a particulate carrier.
Claim 47
Dependent Claim
43 words
A radioactive composition for the treatment of rheumatoid arthritis comprising a particulate aggregate containing particles having a minimum size of one micron, said particulate aggregate including particles containing holmium-166 in an amount effective for the treatment of rheumatoid arthritis and a particulate carrier.
Claim 48
Dependent Claim
35 words
A composition for the treatment of arthritis including particles, the particles having a minimum size of one micron, including particles containing holmium-166 and a particulate carrier suitable for injection at the site of the arthritis.
Claim 49
Dependent Claim
35 words
A composition for the treatment of arthritis including particles, the particles having a minimum size of one micron, including particles containing holmium-166 and a particulate carrier suitable for injection at the site of the arthritis.
Claim 50
Dependent Claim
37 words
A composition for the treatment of rheumatoid arthritis including particles, the particles having a minimum size of one micron, including particles containing holmium-166 and a particulate carrier suitable for injection at the site of the rheumatoid arthritis.
Claim 51
Dependent Claim
37 words
A composition for the treatment of rheumatoid arthritis including particles, the particles having a minimum size of one micron, including particles containing holmium-166 and a particulate carrier suitable for injection at the site of the rheumatoid arthritis.
Claim 52
Dependent Claim
39 words
A composition for the treatment of inflamed synovial tissues including particles, the particles having a minimum size of one micron, including particles containing holmium-166 and a particulate carrier suitable for injection at the site of the inflamed synovial tissues.
Claim 53
Dependent Claim
39 words
A composition for the treatment of inflamed synovial tissues including particles, the particles having a minimum size of one micron, including particles containing holmium-166 and a particulate carrier suitable for injection at the site of the inflamed synovial tissues.
Claim 54
Dependent Claim
14 words
The radioactive composition described in claim 34 wherein said carrier includes a metallic hydroxide.
Claim 55
Dependent Claim
13 words
The radioactive composition described in claim 34 wherein said carrier includes ferric hydroxide.
Claim 56
Dependent Claim
13 words
The radioactive composition described in claim 34 wherein said carrier includes aluminum hydroxide.
Claim 57
Independent Claim
47 words
A method of conducting radiation synovectomy including the step of injecting an aggregate composition containing particles, the particles having a minimum size of one micron into a patient in the vicinity of synovial tissues to be treated, wherein the injected aggregate composition contains particles which include holmium-166.
Claim 58
Independent Claim
47 words
A method of conducting radiation synovectomy including the step of injecting an aggregate composition containing particles, the particles having a minimum size of one micron into a patient in the vicinity of synovial tissues to be treated, wherein the injected aggregate composition contains particles which include holmium-166.
Claim 59
Dependent Claim
21 words
The method described in claim 38 wherein the injected composition contains an aggregate of particles containing holmium-166 and a particulate carrier.
Claim 60
Dependent Claim
23 words
The method described in claim 38 wherein the injected composition contains an aggregate of particles containing holmium-166 and a particulate metallic hydroxide carrier.
Claim 61
Dependent Claim
22 words
The method described in claim 38 wherein the injected composition contains an aggregate of particles containing holmium-166 and a monoclonal antibody carrier.
Claim 62
Dependent Claim
44 words
A radioactive composition for use in treated inflamed synovial tissues comprising an injectable particulate aggregate containing particles having a minimum size of one micron, said particulate aggregate including particles containing holmium-166, said composition suitable for injection at the site of the inflamed synovial tissues.
Claim 63
Dependent Claim
44 words
A radioactive composition for use in treated inflamed synovial tissues comprising an injectable particulate aggregate containing particles having a minimum size of one micron, said particulate aggregate including particles containing holmium-166, said composition suitable for injection at the site of the inflamed synovial tissues.
Claim 64
Dependent Claim
16 words
The radioactive composition described in claim 42 including a carrier compatible with the tissues undergoing treatment.
Claim 65
Dependent Claim
14 words
The radioactive composition described in claim 42 wherein said carrier is a monoclonal antibody.
Claim 66
Dependent Claim
17 words
The radioactive composition described in claim 42 including a particulate carrier compatible with the tissues undergoing treatment.
Claim 67
Dependent Claim
15 words
The radioactive composition described in claim 45 wherein said carrier is a particulate metallic hydroxide.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1994-10-28 | 1995-04-29 | 1995-10-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-10-28 | 1999-04-29 | 1999-10-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-10-28 | 2003-04-29 | 2003-10-29 | $7700.00 | Window Closed / Lapsed |