Patent US5057501A successfully refreshed from Google Patents.
US5057501A
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Methods for treatment of papulosquamous and eczematous diseases
Assignee: DMK Pharmaceuticals Corp
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Filing: 1990-03-13
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Granted: 1991-10-15
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Expires: 2010-03-13
Abstract
Abstract Certain compounds having sesquiterpene structures, when combined with monocarboxylic fatty acids, esters or amides, have efficacy in the treatment of papulosquamous and eczematous diseases. Prime examples of the sesquiterpene compounds are artemisinin and analogs, and prime examples of the monocarboxylic fatty acid compounds are lauric acid, monolaurin and lauryl-N,N-dimethylamide.
Inventors
- 👤 Carl R. Thornfeldt
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 06:22
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/335; A61K31/35; A61K31/70
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
67 words
A method for the treatment of a subject suffering a disease condition selected from papulosquamous and eczematous diseases, said method comprising administering to said subject a therapeutically effective amount of a combination of: (a) a compound containing an oxygenated tricyclic sesquiterpene structure containing an endoperoxide group, and (b) a compound selected from the group consisting of C 5 -C 19 monocarboxylic acids and esters and amides thereof.
Claim 2
Independent Claim
67 words
A method for the treatment of a subject suffering a disease condition selected from papulosquamous and eczematous diseases, said method comprising administering to said subject a therapeutically effective amount of a combination of: (a) a compound containing an oxygenated tricyclic sesquiterpene structure containing an endoperoxide group, and (b) a compound selected from the group consisting of C 5 -C 19 monocarboxylic acids and esters and amides thereof.
Claim 3
Dependent Claim
30 words
A method in accordance with claim 1 in which compound (a) is a member selected from the group consisting of sesquiterpene lactones and alcohols, carbonates, esters, ethers and sulfonates thereof.
Claim 4
Dependent Claim
51 words
A method in accordance with claim 1 in which compound (a) is one having the formula ##STR8## in which R is a member selected from the group consisting of ##STR9## where R' is a member selected from the group consisting of alkyl, ##STR10## in which M is sodium or potassium, ##STR11##
Claim 5
Dependent Claim
54 words
A method in accordance with claim 1 in which compound (a) is one having the formula ##STR12## in which R is a member selected from the group consisting of ##STR13## where R' is a member selected from the group consisting of C 1 -C 4 alkyl, ##STR14## in which M is sodium or ##STR15##
Claim 6
Dependent Claim
27 words
A method in accordance with claim 4 in which R' is a member selected from the group consisting of ##STR16## in which M is sodium or potassium.
Claim 7
Dependent Claim
43 words
A method in accordance with claim 1 in which compound (a) is one having the formula ##STR17## in which R is a member selected from the group consisting of ##STR18## and esters, ethers, carbonates and sulfates of those in which R is ##STR19##
Claim 8
Dependent Claim
32 words
A method in accordance with claim 4 in which R is a member selected from the group consisting of ##STR20## where R' is a member selected from the group consisting of ##STR21##
Claim 9
Dependent Claim
31 words
A method in accordance with claim 1 in which compound (a) is a member selected from the group consisting of artemisinin, dihydroartemisinin, artemether, arteether, artesunate, artelinic acid and dihydroartemisinin propyl carbonate.
Claim 10
Dependent Claim
13 words
A method in accordance with claim 1 in which compound (a) is artesunate.
Claim 11
Dependent Claim
35 words
A method in accordance with claim 1 in which compound (b) is a member selected from the group consisting of C 9 -C 18 monocarboxylic acids, and sucrose esters, glycerol esters, and methyl amides thereof.
Claim 12
Dependent Claim
26 words
A method in accordance with claim 1 in which compound (b) is a member selected from the group consisting of lauric acid, monolaurin, and lauryl dimethylamide.
Claim 13
Dependent Claim
23 words
A method in accordance with claim 1 in which compound (b) is a member selected from the group consisting of monolaurin and lauryl-N,N-dimethylamide.
Claim 14
Dependent Claim
82 words
A method in accordance with claim 1 in which compound (a) is one having the formula ##STR22## in which R is a member selected from the group consisting of ##STR23## where R' is a member selected from the group consisting of C 1 -C 4 alkyl, ##STR24## in which M is sodium or potassium, ##STR25## and compound (b) is a member selected from the group consisting of C 9 -C 18 monocarboxylic acids, and sucrose esters, glycerol esters, and methyl amides thereof.
Claim 15
Dependent Claim
68 words
A method in accordance with claim 1 in which compound (a) is one having the formula ##STR26## in which R is a member selected from the group consisting of ##STR27## where R' is a member selected from the group consisting of CH 3 , C 2 H 5 , ##STR28## and compound (b) is a member selected from the group consisting of lauric acid, monolaurin, and lauryl dimethylamide.
Claim 16
Dependent Claim
46 words
A method in accordance with claim 1 in which compound (a) is a member selected from the group consisting of artemisinin, dihydroartemisinin, artemether, arteether, artesunate, artelinic acid and dihydroartemisinin propyl carbonate; and compound (b) is a member selected from the group consisting of monolaurin and lauryl-N,N-dimethylamide.
Claim 17
Dependent Claim
48 words
A method in accordance with claim 1 in which said disease condition is selected from the group consisting of psoriasis, lichen planus, pityriasis, parapsoriasis, seborrheic dermatitis, atopic dermatitis, contact allergic or irritant dermatitis, dyshidrosis, lichen simplex chronicus, eczema cracquele, and cutaneous T cell lymphoma patch and plaque stages.
Claim 18
Dependent Claim
25 words
A method in accordance with claim 1 in which said disease condition is selected from the group consisting of psoriasis, seborrheic dermatitis, and atopic dermatitis.
Claim 19
Dependent Claim
38 words
A method in accordance with claim 1 comprising administering to said subject a formulation comprising from about 0.01% to about 35% by weight of compound (a), and from about 0.25% to about 35% by weight of compound (b).
Claim 20
Dependent Claim
38 words
A method in accordance with claim 1 comprising administering to said subject a formulation comprising from about 0.025% to about 10% by weight of compound (a), and from about 1% to about 15% by weight of compound (b).
Claim 21
Dependent Claim
30 words
A method in accordance with claim 1 in which said combination further comprises a member selected from the group consisting of glucocorticosteroids, chemotherapeutic agents, retinoids, antibiotics, tars and antibacterial agents.
Claim 22
Dependent Claim
18 words
A method in accordance with claim 1 comprising administering said combination systemically by oral, intramuscular or intravenous administration.
References Cited (Backward Citations)
US3535422A
Cited
US4978676A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-10-14 | 1995-04-15 | 1995-10-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-10-14 | 1999-04-15 | 1999-10-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-10-14 | 2003-04-15 | 2003-10-15 | $7700.00 | Window Closed / Lapsed |