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US5053520A
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Heterobifunctional maleimido containing coupling agents
Assignee: Abbott Laboratories
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Filing: 1989-10-01
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Granted: 1991-10-01
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Expires: 2009-10-01
Abstract
Abstract Novel polyamino acid based coupling agents are disclosed. These reagents are useful for conjugating proteins (e.g. antibodies to enzymes) for use in diagnostic assays.
Inventors
- 👤 Christopher Bieniarz
- 👤 Christopher J. Welch
- 👤 Grady Barnes
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 18:37
CPC Classifications
C; C07; C07K; C07K17/00; C07K17/02; C07K17/06; C07D; C07D207/00; C07D207/46; C12; C12N; C12N11/00; C12N11/02; C12N11/06
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
37 words
A heterobifunctional reagent for linking two proteins comprising: ##STR17## wherein X is amino acid having from three to ten carbon atoms in a straight chain; R is cycloaklyl or alkyl-cycloalkyl; and n is from three to ten.
Claim 2
Dependent Claim
37 words
A heterobifunctional reagent for linking two proteins comprising: ##STR17## wherein X is amino acid having from three to ten carbon atoms in a straight chain; R is cycloaklyl or alkyl-cycloalkyl; and n is from three to ten.
Claim 3
Dependent Claim
9 words
The reagent of claim 1 wherein R is cyclohexylmethyl.
Claim 4
Dependent Claim
12 words
The reagent of claim 1 wherein n is from two to five.
Claim 5
Dependent Claim
9 words
The reagent of claim 3 wherein n is three.
Claim 6
Dependent Claim
17 words
The reagent of claim 1 wherein X is a polyamide formed from repeated units of 6-aminocaproic acid.
Claim 7
Dependent Claim
12 words
The reagent of claim 1 comprising a compound of the formula: ##STR18##
References Cited (Backward Citations)
US4994385A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-09-30 | 1995-04-01 | 1995-10-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-09-30 | 1999-04-01 | 1999-10-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-09-30 | 2003-04-01 | 2003-10-01 | $7700.00 | Window Closed / Lapsed |