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US5053048A
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US
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Thromboresistant coating
Assignee: Cordis Corp
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Filing: 1990-11-08
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Granted: 1991-10-01
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Expires: 2010-11-08
Abstract
Abstract A thromboresistant coating, method for forming same on a medical device, and the medical device thus prepared are provided. The thromboresistant coating is a highly cross-linked three-dimensional matrix copolymerized from an aminosilane component and a silane other than the aminosilane that is cured and dried into a thick matrix having amino groups interspersed therethroughout. The amino groups facilitate attachment of an antithrombogenic agent to the matrix and thus to the medical device. In addition, an antithrombogenic material is secured to the aminosilane copolymeric matrix.
Inventors
- 👤 Leonard Pinchuk
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 05:41
CPC Classifications
A; A61; A61L; A61L33/00; A61L33/0005; A61L33/0011; A61L33/0029; A61L33/06; A61L33/068; Y; Y10; Y10S; Y10S128/00; Y10S128/21
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
150 words
A thromboresistant coating for a medical device having a body fluid-contacting surface for contacting blood, other body fluids and the like, the thromboresistant coating comprising: a three-dimensional copolymeric matrix secured to the body fluid-contacting surface of the medical device, said copolymeric matrix being a copolymer including an aminosilane of the formula: H 2 N-R'-Si(OR) 3 or H 2 N-R'-SiX 3 , wherein R' is a spacer group selected from the group consisting of alkyl groups, aromatic groups and imine-containing groups, wherein OR is an alkoxy group or an hydroxy group and wherein X is a halogen, wherein said copolymeric matrix is a copolymer or graft copolymer of said aminosilane and of a silane other than said aminosilane, and wherein said copolymer matrix was polymerized from a composition that contains substantially only the aminosilane and the silane other than said aminosilane; and an antithrombogenic material secured to said aminosilane copolymeric matrix.
Claim 2
Dependent Claim
150 words
A thromboresistant coating for a medical device having a body fluid-contacting surface for contacting blood, other body fluids and the like, the thromboresistant coating comprising: a three-dimensional copolymeric matrix secured to the body fluid-contacting surface of the medical device, said copolymeric matrix being a copolymer including an aminosilane of the formula: H 2 N-R'-Si(OR) 3 or H 2 N-R'-SiX 3 , wherein R' is a spacer group selected from the group consisting of alkyl groups, aromatic groups and imine-containing groups, wherein OR is an alkoxy group or an hydroxy group and wherein X is a halogen, wherein said copolymeric matrix is a copolymer or graft copolymer of said aminosilane and of a silane other than said aminosilane, and wherein said copolymer matrix was polymerized from a composition that contains substantially only the aminosilane and the silane other than said aminosilane; and an antithrombogenic material secured to said aminosilane copolymeric matrix.
Claim 3
Dependent Claim
86 words
The thromboresistant coating according to claim 1, wherein said other silane has the formula: ##STR2## wherein RO is an alkoxy group or an hydroxy group, wherein X is a halogen, wherein R" is a group selected from the group consisting of alkyl groups, aromatic groups and combinations thereof, wherein n designates the number of silane blocks and is between 1 and about 300,000, and wherein R, together with the terminal 0 of the terminal silane block is an alkoxy group, an hydroxy group or a halogen.
Claim 4
Dependent Claim
65 words
The thromboresistant coating according to claim 1, wherein said other silane is of the formula: R" x -Si(OR) y or R" x -SiX y wherein OR is an alkoxy group or an hydroxy group, wherein X is a halogen, wherein R" is a group that is an alkyl group, an aromatic group or combinations thereof, and wherein the sum of x and y is four.
Claim 5
Dependent Claim
16 words
The thromboresistant coating according to claim 1, wherein said other silane is an acetoxy terminated polysilane.
Claim 6
Dependent Claim
12 words
The thromboresistant coating according to claim 4, wherein said aminosilane is N-(2-aminoalkyl-3-aminoalkyl)trialkoxysilane.
Claim 7
Dependent Claim
22 words
The thromboresistant coating according to claim 5, wherein said antithrombogenic material includes an extender bound thereto and bound to said copolymeric matrix.
Claim 8
Dependent Claim
155 words
A medical device having a thromboresistant coating over a body fluid-contacting surface of the medical device for contacting blood, other body fluids and the like, wherein the thromboresistant coating comprises: a three-dimensional copolymeric matrix secured to the body fluid-contacting surface of the medical device, said copolymeric matrix being a copolymer including an aminosilane of the formula: H 2 N-R'-Si(OR) 3 or H 2 N-R'-SiX 3 , wherein R' is a spacer group selected from the group consisting of alkyl groups, aromatic groups and imine-containing groups, wherein OR is an alkoxy group or an hydroxy group and wherein X is a halogen, wherein said copolymeric matrix is a copolymer or graft copolymer of said aminosilane and of a silane other than said aminosilane, and wherein said copolymer matrix was polymerized from a composition that contains substantially only the aminosilane and the silane other than said aminosilane; and an antithrombogenic material secured to said aminosilane polymeric matrix.
Claim 9
Dependent Claim
155 words
A medical device having a thromboresistant coating over a body fluid-contacting surface of the medical device for contacting blood, other body fluids and the like, wherein the thromboresistant coating comprises: a three-dimensional copolymeric matrix secured to the body fluid-contacting surface of the medical device, said copolymeric matrix being a copolymer including an aminosilane of the formula: H 2 N-R'-Si(OR) 3 or H 2 N-R'-SiX 3 , wherein R' is a spacer group selected from the group consisting of alkyl groups, aromatic groups and imine-containing groups, wherein OR is an alkoxy group or an hydroxy group and wherein X is a halogen, wherein said copolymeric matrix is a copolymer or graft copolymer of said aminosilane and of a silane other than said aminosilane, and wherein said copolymer matrix was polymerized from a composition that contains substantially only the aminosilane and the silane other than said aminosilane; and an antithrombogenic material secured to said aminosilane polymeric matrix.
Claim 10
Dependent Claim
28 words
The medical device according to claim 7, wherein said copolymeric matrix is a graft copolymer of said aminosilane onto a polymer of the silane other than said aminosilane.
Claim 11
Dependent Claim
19 words
The medical device according to claim 8, wherein said antithrombogenic material includes an extender bound to said graft copolymer.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-09-30 | 1995-04-01 | 1995-10-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-09-30 | 1999-04-01 | 1999-10-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-09-30 | 2003-04-01 | 2003-10-01 | $7700.00 | Window Closed / Lapsed |