US5047249A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Compositions and methods for treating skin conditions and promoting wound healing
Assignee: CIRO'S TOUCH Ltd A CORP OF
•
Filing: 1989-03-03
•
Granted: 1991-09-10
•
Expires: 2009-03-03
Abstract
Abstract This invention relates to activated protein-containing compositions comprising reducing agents, oxidizing agents and/or anti-oxidants and methods of use. The therapeutic compositions and methods of the present invention are particularly effective in promoting wound healing, and in inhibiting certain skin disorders, including eczema and seborrhea, sclerodema and acne. The therapeutic compositions and methods of the present invention have also shown enhanced effect as veterinary tools in reducing the debilitation associated with certain skin conditions in mammals including eczematoid dermatitis, chronic dermatitis, equine exuberant granuloma ("proud flesh"), decubitis ulcers, and canine cutaneous granulomas ("lick" granuloma).
Inventors
- 👤 John Rothman
- 👤 Philip A. Band
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 16:37
CPC Classifications
A; A61; A61Q; A61Q5/00; A61Q5/006; A61K; A61K38/00; A61K38/16; A61K38/17; A61K38/1703; A61K38/1709; A61K8/00; A61K8/18; A61K8/19; A61K8/22; A61K8/30; A61K8/64; A61K8/645; A61K8/65; A61Q19/00
Claims Analysis
Total Claims: 39
Claim 1
Independent Claim
122 words
A method for treating abnormal or damaged conditions of the epithelium, including skin, and ungual tissue comprising applying to the affected area a composition comprising: a). about 0.01 to about 12% by weight of a protein containing sufficient cysteinyl groups to covalently bind said protein to said tissue; b). about 0.1 to about 15% by weight of a reducing agent capable of reducing cystine to cysteine in said protein; c). about 0.001 to about 4.0% by weight of an oxidizing agent capable of oxidizing cysteine to cystine; and d). about 81.0% to about 99.889% by weight of at least one component selected from the group consisting of water, acids, bases, buffering agents, emulsifying agents, thickeners, solvents, preservatives, coloring agents and perfuming agents.
Claim 2
Independent Claim
122 words
A method for treating abnormal or damaged conditions of the epithelium, including skin, and ungual tissue comprising applying to the affected area a composition comprising: a). about 0.01 to about 12% by weight of a protein containing sufficient cysteinyl groups to covalently bind said protein to said tissue; b). about 0.1 to about 15% by weight of a reducing agent capable of reducing cystine to cysteine in said protein; c). about 0.001 to about 4.0% by weight of an oxidizing agent capable of oxidizing cysteine to cystine; and d). about 81.0% to about 99.889% by weight of at least one component selected from the group consisting of water, acids, bases, buffering agents, emulsifying agents, thickeners, solvents, preservatives, coloring agents and perfuming agents.
Claim 3
Dependent Claim
13 words
The method according to claim 1 wherein said protein is a keratin protein.
Claim 4
Dependent Claim
16 words
The method according to claim 1 wherein said reducing agent is a salt of thioglycollic acid.
Claim 5
Dependent Claim
13 words
The method according to claim 3 wherein said reducing agent is ammonium thioglycollate.
Claim 6
Dependent Claim
22 words
The method according to claim 2 wherein said oxidizing agent is selected from the group consisting of sodium perborate and hydrogen peroxide.
Claim 7
Dependent Claim
21 words
The method according to claim 5 wherein said oxidizing agent comprises about 0.001 to about 1.5% by weight of said composition.
Claim 8
Dependent Claim
13 words
The method according to claim 6 wherein said oxidizing agent is hydrogen peroxide.
Claim 9
Dependent Claim
26 words
The method according to claim 1 wherein said protein is a keratin protein, said reducing agent is ammonium thioglycollate and said oxidizing agent is hydrogen peroxide.
Claim 10
Dependent Claim
11 words
The method according to claim 1 wherein said condition is dandruff.
Claim 11
Dependent Claim
11 words
The method according to claim 1 wherein said condition is sebborhea.
Claim 12
Dependent Claim
13 words
The method according to claim 1 wherein said condition is canine cutaneous granuloma.
Claim 13
Dependent Claim
13 words
The method according to claim 1 wherein said condition is equine exuberant granuloma.
Claim 14
Independent Claim
104 words
A method for treating abnormal or damaged conditions of the epithelium including skin, and ungual tissue comprising applying to the affected area a composition comprising: a). about 0.01 to about 12% by weight of a protein containing sufficient cysteinyl groups to covalently bind said protein to said tissue; b). about 0.1 to about 15% by weight of a reducing agent capable of reducing cystine to cysteine in said protein; and c). about 81.0% to about 99.889% by weight of at least one component selected from the group consisting of water, acids, bases buffering agents, emulsifying agents, thickeners, solvents, preservatives, coloring agents and perfuming agents.
Claim 15
Independent Claim
104 words
A method for treating abnormal or damaged conditions of the epithelium including skin, and ungual tissue comprising applying to the affected area a composition comprising: a). about 0.01 to about 12% by weight of a protein containing sufficient cysteinyl groups to covalently bind said protein to said tissue; b). about 0.1 to about 15% by weight of a reducing agent capable of reducing cystine to cysteine in said protein; and c). about 81.0% to about 99.889% by weight of at least one component selected from the group consisting of water, acids, bases buffering agents, emulsifying agents, thickeners, solvents, preservatives, coloring agents and perfuming agents.
Claim 16
Dependent Claim
13 words
The method according to claim 13 wherein said protein is a keratin protein.
Claim 17
Dependent Claim
13 words
The method according to claim 13 wherein said reducing agent is ammonium thioglycollate.
Claim 18
Dependent Claim
20 words
The method according to claim 13 wherein said protein is a keratin protein and said reducing agent is ammonium thioglycollate.
Claim 19
Dependent Claim
11 words
The method according to claim 13 wherein said condition is dandruff.
Claim 20
Dependent Claim
11 words
The method according to claim 13 wherein said condition is sebborhea.
Claim 21
Dependent Claim
13 words
The method according to claim 13 wherein said condition is canine cutaneous granuloma.
Claim 22
Dependent Claim
13 words
The method according to claim 13 wherein said condition is equine exuberant granuloma.
Claim 23
Dependent Claim
90 words
A composition for treating acne comprising: (a) about 0.01 to about 12% by weight of a protein containing sufficient cysteinyl groups to covalently bind to the skin or scalp; (b) about 0.1 to about 15% by weight of a reducing agent capable of reducing cystine to cysteine in said protein; (c) at least about 73% by weight of at least one component selected from the group consisting of water, bases, acids, buffering agents, emulsifying agents, thickeners, coloring agents and perfuming agents; and (d) an effective amount of an anti-acne agent.
Claim 24
Dependent Claim
90 words
A composition for treating acne comprising: (a) about 0.01 to about 12% by weight of a protein containing sufficient cysteinyl groups to covalently bind to the skin or scalp; (b) about 0.1 to about 15% by weight of a reducing agent capable of reducing cystine to cysteine in said protein; (c) at least about 73% by weight of at least one component selected from the group consisting of water, bases, acids, buffering agents, emulsifying agents, thickeners, coloring agents and perfuming agents; and (d) an effective amount of an anti-acne agent.
Claim 25
Dependent Claim
21 words
The composition according to claim 21 wherein said anti-acne agent is selected from the group consisting of benzoyl peroxide and tetracycline.
Claim 26
Dependent Claim
11 words
The composition according to claim 21 further comprising an oxidizing agent.
Claim 27
Dependent Claim
11 words
The composition according to claim 21 further comprising a volatile antioxidant.
Claim 28
Dependent Claim
108 words
A composition for treating wounds and damaged conditions of the epithelium, including skin comprising: (a) about 0.01 to about 12% by weight of a protein containing sufficient cysteinyl groups to covalently bind to a wounded area or the skin selected from the group consisting or ribonuclease T1, human serum albumin, and fibrinogen and its derivatives; (b) about 0.1% to about 15% by weight of a reducing agent capable of reducing cystine groups to cysteine groups; and (c) about 73% to about 99.98% by weight of at least one component selected from the group consisting of water, bases, acids, buffering agents, emulsifying agents, thickeners, coloring agents and perfuming agents.
Claim 29
Dependent Claim
108 words
A composition for treating wounds and damaged conditions of the epithelium, including skin comprising: (a) about 0.01 to about 12% by weight of a protein containing sufficient cysteinyl groups to covalently bind to a wounded area or the skin selected from the group consisting or ribonuclease T1, human serum albumin, and fibrinogen and its derivatives; (b) about 0.1% to about 15% by weight of a reducing agent capable of reducing cystine groups to cysteine groups; and (c) about 73% to about 99.98% by weight of at least one component selected from the group consisting of water, bases, acids, buffering agents, emulsifying agents, thickeners, coloring agents and perfuming agents.
Claim 30
Independent Claim
100 words
A method for diminishing the effects of acne scars in the skin comprising applying to the scarred area a composition comprising: a). about 0.01 to about 12% by weight of a protein containing sufficient cysteinyl groups to covalently bind said protein to the skin; b). about 0.1 to about 15% by weight of a reducing agent capable of reducing cystine to cysteine in said protein; and c). about 81.0% to about 99.889% by weight of at least one component selected from the group consisting of water, acids, bases, buffering agents, emulsifying agents, thickeners, solvents, preservatives, coloring agents and perfuming agents.
Claim 31
Independent Claim
100 words
A method for diminishing the effects of acne scars in the skin comprising applying to the scarred area a composition comprising: a). about 0.01 to about 12% by weight of a protein containing sufficient cysteinyl groups to covalently bind said protein to the skin; b). about 0.1 to about 15% by weight of a reducing agent capable of reducing cystine to cysteine in said protein; and c). about 81.0% to about 99.889% by weight of at least one component selected from the group consisting of water, acids, bases, buffering agents, emulsifying agents, thickeners, solvents, preservatives, coloring agents and perfuming agents.
Claim 32
Dependent Claim
13 words
The method according to claim 26 wherein said protein is a keratin protein.
Claim 33
Dependent Claim
13 words
The method according to claim 27 wherein said reducing agent is ammonium thioglycollate.
Claim 34
Dependent Claim
20 words
The method according to claim 28 wherein said protein is a keratin protein and said reducing agent is ammonium thioglycollate.
Claim 35
Dependent Claim
31 words
The method according to claim 29 wherein said composition further comprises about 0.001 to about 4.0% by weight of an oxidizing agent capable of oxidizing cysteine to cystine in said protein.
Claim 36
Dependent Claim
14 words
The method according to claim 13 wherein said composition further includes a volatile antioxidant.
Claim 37
Dependent Claim
24 words
The method according to claim 31 wherein said composition further includes an effective amount of an oxidizing agent capable of oxidizing cysteine to cystine.
Claim 38
Dependent Claim
36 words
The method according to claim 1 wherein said condition is selected from the group consisting of wounds, sebborhea, psoriasis, dandruff, acne, scars, callouses, corns, burns, rashes, dermatitis, equine exuberant granuloma, decubitis ulcers, and canine cutaneous granulomas.
Claim 39
Dependent Claim
37 words
The method according to claim 13 where in said condition is selected from the group consisting of wounds, sebborhea, psoriasis, dandruff, acne, scars, callouses, corns, burns, rashes, dermatitis, equine exuberant granuloma, decubitis ulcers, and canine cutaneous granulomas.
References Cited (Backward Citations)
US2434688A
Cited
US2413983A
Cited
US2474339A
Cited
US2540494A
Cited
US2631965A
Cited
US2719814A
Cited
US3514515A
Cited
US4195095A
Cited
US3683939A
Cited
US3837349A
Cited
US3842848A
Cited
US3954974A
Cited
US3961634A
Cited
US3957065A
Cited
US4158704A
Cited
US4390525A
Cited
JPS5716810A
Cited
US4459284A
Cited
US4450097A
Cited
US4427651A
Cited
US4426376A
Cited
FR2522657A1
Cited
US4438102A
Cited
US4530828A
Cited
US4600028A
Cited
GB2160419A
Cited
US4711780A
Cited
US4605555A
Cited
US4818520A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-09-09 | 1995-03-11 | 1995-09-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-09-09 | 1999-03-11 | 1999-09-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-09-09 | 2003-03-11 | 2003-09-10 | $7700.00 | Window Closed / Lapsed |