US4605555A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Composition and method for treating keratosic disorder of skin and mucosa
Assignee: Sunstar Inc
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Filing: 1984-09-20
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Granted: 1986-08-12
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Expires: 2004-09-20
Abstract
Abstract A pharmaceutical composition for treating keratosic disorders of skin and mucosa, particularly, lichen planus and leukoplakia, by topical or local administration which comprises an effective amount of human interferon, a trihydric or more higher polyhydric sugar alcohol, an organic acid buffer and, optionally, an anionic surfactant and albumin, and a conventional pharmaceutical carrier or diluent. A method for treating a human subject suffering from keratosic disorders of skin and mucosa by using this composition is also provided.
Inventors
- 👤 Mitsunobu Sato
- 👤 Yasuhiro Katsuragi
- 👤 Yasuo Sakano
- 👤 Kunio Sugihara
- 👤 Kenji Aimoto
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 09:55
CPC Classifications
A; A61; A61K; A61K47/00; A61K47/06; A61K47/20; A61K38/00; A61K38/16; A61K38/17; A61K38/19; A61K38/21; A61K47/08; A61K47/10; A61K47/26; A61K9/00; A61K9/0012; A61K9/0014
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
61 words
A method for treating a human subject suffering from lichen planus or leukoplakia which comprises externally applying a pharmaceutical composition comprising an effective amount of human interferon, 15 to 70% by weight of a trihydric of higher polyhydric sugar alcohol, an organic acid buffer and a conventional pharmaceutical carrier or diluent, the pH of the composition being about 3 to 6.
Claim 2
Independent Claim
61 words
A method for treating a human subject suffering from lichen planus or leukoplakia which comprises externally applying a pharmaceutical composition comprising an effective amount of human interferon, 15 to 70% by weight of a trihydric of higher polyhydric sugar alcohol, an organic acid buffer and a conventional pharmaceutical carrier or diluent, the pH of the composition being about 3 to 6.
Claim 3
Dependent Claim
28 words
A method according to claim 1, wherein the composition is applied in such an amount that 10 to 10 8 IU of interferon is applied per single dosage.
Claim 4
Dependent Claim
33 words
A method according to claim 1, wherein the polyhydric sugar alcohol in the composition is a member selected from the group consisting of glycerin, erythritol, arabitol, xylitol, sorbitol, mannitol and a mixture thereof.
Claim 5
Dependent Claim
50 words
A method according to claim 1, wherein the organic acid buffer in the composition is a member selected from the group consisting of citrate buffer, succinate buffer, fumarate buffer, gluconate buffer, oxalate buffer, lactate buffer and acetate buffer and is formulated in an amount of 0.01 to 0.2 mole/kg composition.
Claim 6
Dependent Claim
14 words
A method according to claim 1, wherein the composition further includes an anionic surfactant.
Claim 7
Dependent Claim
99 words
A method according to claim 5, wherein the anionic surfactant is a member selected from the group consisting of sodium alkyl sulfate the alkyl group of which has 8 to 18 carbon atoms; sodium polyoxyethylene alkyl ether sulfate the average number of mole of ethylene oxide added of which is 2 to 4 and the alkyl group of which has 8 to 18 carbon atoms; sodium alkyl sulfosuccinate the alkyl group of which has 8 to 18 carbon atoms; and a mixture thereof and is formulated in an amount of 0.008 to 4% by weight based on the composition.
Claim 8
Dependent Claim
25 words
A method according to claim 1, wherein the composition further includes albumin in an amount of 0.01 to 1% by weight based on the composition.
Claim 9
Dependent Claim
23 words
A method according to claim 1, wherein the composition is in the form of a solid and contains as a binder carboxymethyl cellulose.
Claim 10
Dependent Claim
20 words
A method according to claim 1, wherein the composition is in the form suitable for application in the oral cavity.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-08-11 | 1990-02-10 | 1990-08-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-08-11 | 1994-02-10 | 1994-08-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-08-11 | 1998-02-10 | 1998-08-12 | $7700.00 | Window Closed / Lapsed |