Patent US5043152A successfully refreshed from Google Patents.
US5043152A
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Novel iodinated non-ionic triiodobenzene compounds and contrast media containing them
Assignee: Guerbet SA
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Filing: 1990-02-16
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Granted: 1991-08-27
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Expires: 2010-02-16
Abstract
Abstract The invention relates to novel non-ionic compounds of formula <IMAGE> These compounds can be used as contrast media.
Inventors
- 👤 Michel Schaefer
- 👤 Maryse Dugast-Zrihen
- 👤 Michel Guillemot
- 👤 Didier Doucet
- 👤 Dominique Meyer
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 18:36
CPC Classifications
C; C07; C07C; C07C237/00; C07C237/28; C07C237/46; A; A61; A61K; A61K49/00; A61K49/04; A61K49/0433
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
155 words
A compound of the formula: ##STR27## in which R 1 is selected from a group of the formula ##STR28## in which R 5 is selected from C 1 -C 4 alkyl, C 1 -C 4 hydroxyalkyl and C 1 -C 4 polyhydroxyalkyl, and R 6 is selected from hydrogen, C 1 -C 4 alkyl, C 1 -C 4 hydroxy alkyl and C 1 -C 4 polyhydroxyalkyl, and a group of the formula ##STR29## in which R 7 is selected from C 1 -C 4 hydroxyalkyl and C 1 -C 4 polyhydroxyalkyl, and R 8 is selected from hydrogen and C 1 -C 4 alkyl, R 2 is selected from C 1 -C 4 hydroxyalkyl and C 1 -C 4 polyhydroxyalkyl, R 3 is selected from hydrogen and C 1 -C 4 alkyl, and R 4 is selected from hydrogen, C 1 -C 4 alkyl, C 1 -C 4 hydroxyalkyl and C 1 -C 4 polyhydroxyalkyl.
Claim 2
Dependent Claim
155 words
A compound of the formula: ##STR27## in which R 1 is selected from a group of the formula ##STR28## in which R 5 is selected from C 1 -C 4 alkyl, C 1 -C 4 hydroxyalkyl and C 1 -C 4 polyhydroxyalkyl, and R 6 is selected from hydrogen, C 1 -C 4 alkyl, C 1 -C 4 hydroxy alkyl and C 1 -C 4 polyhydroxyalkyl, and a group of the formula ##STR29## in which R 7 is selected from C 1 -C 4 hydroxyalkyl and C 1 -C 4 polyhydroxyalkyl, and R 8 is selected from hydrogen and C 1 -C 4 alkyl, R 2 is selected from C 1 -C 4 hydroxyalkyl and C 1 -C 4 polyhydroxyalkyl, R 3 is selected from hydrogen and C 1 -C 4 alkyl, and R 4 is selected from hydrogen, C 1 -C 4 alkyl, C 1 -C 4 hydroxyalkyl and C 1 -C 4 polyhydroxyalkyl.
Claim 3
Dependent Claim
27 words
A compound according to claim 1, having the formula: ##STR30## in which R 2 , R 3 and R 4 have the meanings given in claim 1.
Claim 4
Dependent Claim
9 words
A compound according to claim 1 which is 5-[3-hydroxy-2-(hydroxymethyl)-N-(2,3-dihydroxypropyl)propionamido]-N',N"-bis-(2-hydroxyethyl)-2,4,6-triiodoisophthalamide.
Claim 5
Dependent Claim
10 words
A compound according to claim 1 which is 5-glycolamido-3-[3-hydroxy-2-(hydroxymethyl)-N-(2,3-dihydroxypropyl)propionamido]-2,4,6-triiodo-N-hydroxyethyl benzamide.
Claim 6
Dependent Claim
10 words
A compound according to claim 1 which is 3,5-bis-(3-hydroxy-2-hydroxymethyl-propionamido-2,4,6-triiodo-N-(2,3-dihydroxypropyl) benzamide.
Claim 7
Dependent Claim
9 words
A compound according to claim 1 which is 5-[3-hydroxy-2-(hydroxymethyl)-N-(2-hydroxyethyl)-propionamido]-N-(2-hydroxyethyl)-N'-(2,3-dihydroxypropyl)-2,4,6-triiodo-isophthalamide.
Claim 8
Dependent Claim
10 words
A compound according to claim 1 which is 5-[3-hydroxy-2-(hydroxymethyl)-propionamido]-N', N"-dimethyl]-N',N"-bis-(2,3-dihydroxypropyl)-2,4,6-triiodoisophtalamide.
Claim 9
Dependent Claim
9 words
A compound according to claim 1 which is 5-[3-hydroxy-2(hydroxymethyl)-N-(2,3-dihydroxypropyl)-propionamido]-N',N"-dimethyl-N',N"-bis(2-hydroxyethyl)-2,4,6-triiodoisophtalamide.
Claim 10
Dependent Claim
32 words
A contrast medium comprising an effective amount of at least one compound according to claim 1, in admixture with a pharmacologically acceptable excipient, said amount being effective to provide contrast during radiography.
Claim 11
Dependent Claim
14 words
A contrast medium according to claim 9, comprising an aqueous solution of the compound(s).
Claim 12
Dependent Claim
155 words
A compound of the formula: ##STR31## in which R 1 is selected from a group of the formula ##STR32## in which R 5 is selected from C 1 -C 4 alkyl, C 1 -C 4 hydroxyalkyl and C 1 -C 4 polyhydroxyalkyl, and R 6 is selected from hydrogen, C 1 -C 4 alkyl, C 1 -C 4 hydroxyalkyl and C 1 -C 4 polyhydroxyalkyl; and a group of the formula ##STR33## in which R 7 is selected from C 1 -C 4 hydroxyalkyl and C 1 -C 4 polyhydroxyalkyl, and R 8 is selected from hydrogen and C 1 -C 4 alkyl, R 2 is selected from hydrogen, C 1 -C 4 hydroxyalkyl and C 1 -C 4 polyhydroxyalkyl, R 3 is selected from hydrogen and C 1 -C 4 alkyl, and R 4 is selected from hydrogen, C 1 -C 4 alkyl, C 1 -C 4 hydroxyalkyl and C 1 -C 4 polyhydroxyalkyl.
Claim 13
Dependent Claim
155 words
A compound of the formula: ##STR31## in which R 1 is selected from a group of the formula ##STR32## in which R 5 is selected from C 1 -C 4 alkyl, C 1 -C 4 hydroxyalkyl and C 1 -C 4 polyhydroxyalkyl, and R 6 is selected from hydrogen, C 1 -C 4 alkyl, C 1 -C 4 hydroxyalkyl and C 1 -C 4 polyhydroxyalkyl; and a group of the formula ##STR33## in which R 7 is selected from C 1 -C 4 hydroxyalkyl and C 1 -C 4 polyhydroxyalkyl, and R 8 is selected from hydrogen and C 1 -C 4 alkyl, R 2 is selected from hydrogen, C 1 -C 4 hydroxyalkyl and C 1 -C 4 polyhydroxyalkyl, R 3 is selected from hydrogen and C 1 -C 4 alkyl, and R 4 is selected from hydrogen, C 1 -C 4 alkyl, C 1 -C 4 hydroxyalkyl and C 1 -C 4 polyhydroxyalkyl.
Claim 14
Dependent Claim
32 words
A contrast media comprising an effective amount of at least one compound according to claim 11, in admixture with a pharmacologically acceptable excipient, said amount being effective to provide contrast during radiography.
References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-08-26 | 1995-02-25 | 1995-08-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-08-26 | 1999-02-25 | 1999-08-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-08-26 | 2003-02-25 | 2003-08-27 | $7700.00 | Window Closed / Lapsed |