N-(2,4,6-triiodobenzoyl)-sugar amines
Abstract
Abstract THIS INVENTION RELATES TO NOVEL X-RAY CONTRAST AGENTS PARTICULARLY FOR USE IN THE CEREBROSPINAL CAVITIES, COMPRISING NON-IONIC ALKANOLS CARRYING AT LEAST ONE N-BONDED SECONDARY OR TETIARY AMIDE GROUP AND HAVING AT LEAST TWO HYDROXYL GROUPS AND AT LEAST ONE IODINE ATOM IN THE MOLECULE. PARTICULARLY USEFUL COMPOUNDS INCLUDE THE N-HY DROXYALKYL GROUPS, TRI- AND TETRA-IODOBENZENE CARRYING CARBAMOYL, ACYLAMINO AND/OR ACYLAMINOMETHYL SUBSTITUENTS AND HAVING AT LEAST TWO HYDROXYL GROUPS IN THE MOLECULE AND AT LEAST ONE N-HYDROXYALKYL GROUP. PARTICULARLY PREFERRED COMPOUNDS COMPRISE 2,4,6-TRIIODOBENZAMIDES WHICH MAY BE 3- AND/OR 5-SUBSTITUTED WITH A VARIETY OF GROUPS. THE COMPOUNDS ALL SHOW MARKEDLY LOW TOXICITIES AND A NUMBER SHOW VERY HIGH LEVELS OF WATER SOLUBILITY.
Inventors
- 👤 Torsten H O Almen
- 👤 Johan Haavaldsen
- 👤 Vegard Nordal
Bibliographic Details
Claims Analysis
Total Claims: 0References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1975-10-31 | 1976-05-01 | 1976-10-31 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1979-10-31 | 1980-05-01 | 1980-10-31 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1983-10-31 | 1984-05-01 | 1984-10-31 | $7700.00 | Window Closed / Lapsed |