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US5037381A Expired / Lapsed US ⏱️ 0.0 years remaining

Electrically assisted transdermal transport device and method for renewing the device

Assignee: Vyteris Inc
•
Filing: 1990-07-27
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Granted: 1991-08-06
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Expires: 2010-07-27
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Abstract

Abstract A device for electrically assisted transport of molecules into the skin has a renewable power source and a means for electrically assisted transport of molecules in solution through the skin of an animal. The device has an anode (25) and a battery electrolyte (24) in fluid communication in a disposable part (12) of the means for electrically assisted transport of molecules in solution. The device has an air cathode (14) on a reusable part (11) of the means for electrically assisted transport so that when the reusable (11) and disposable (12) parts join, the battery electrolyte (24) and the air cathode (14) are in fluid communication. The power source is thereby renewed and electrically connected to the means for electrically assisted transport. A method for renewing and replenishing a power source for the device for electrically assisted transport of molecules in solution provides means for electrically assisted transport having a reusable part (11) and a disposable part (12). The method includes providing the reusable part (11) with an air cathode (14) and an anode contact on a support (13) and providing the disposable part (12) having an anode (25) in fluid communication with a battery electrolyte (24) on a carrier (21). The method renews the power source by joining the support (13) and the carrier (21). The battery electrolyte (24), the air cathode (14) and the anode (25) are thus joined in fluid communication and the anode (25) with the anode contact are electrically connected. <IMAGE>

Inventors

  • 👤 C. Randolph Bock
  • 👤 Burton H. Sage, Jr.

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-26 18:43
CPC Classifications
A; A61; A61N; A61N1/00; A61N1/18; A61N1/20; A61N1/30; A61N1/303

Claims Analysis

Total Claims: 23
Claim 1
Independent Claim 112 words
A renewable power source as a portion of a device for electrically assisted transport of molecules into the skin comprising: a means for electrically assisted transport of molecules in solution through the skin of an animal; an anode and a battery electrolyte in fluid communication in a disposable part the means for electrically assisted transport of molecules in solution; an air cathode on a reusable part of the means for electrically assisted transport so that when the reusable and disposable parts join, the battery electrolyte and the air cathode are in fluid communication thus renewing the power source and the power source is electrically connected to the means for electrically assisted transport.
Claim 2
Dependent Claim 112 words
A renewable power source as a portion of a device for electrically assisted transport of molecules into the skin comprising: a means for electrically assisted transport of molecules in solution through the skin of an animal; an anode and a battery electrolyte in fluid communication in a disposable part the means for electrically assisted transport of molecules in solution; an air cathode on a reusable part of the means for electrically assisted transport so that when the reusable and disposable parts join, the battery electrolyte and the air cathode are in fluid communication thus renewing the power source and the power source is electrically connected to the means for electrically assisted transport.
Claim 3
Independent Claim 198 words
A device for electrically assisted transport of molecules through the skin of an animal comprising: a reusable part including a control in circuit for regulating the rate of electrically assisted transport and a support for attachment to the disposable part; an air cathode associated with the support and connected in circuit with the control; an anode contact associated with the support and connected in circuit but otherwise electrically isolated from the air cathode; a disposable part having a carrier shaped to conjugate with the support; an active reservoir system supplied with the molecules in solution, positioned on the carrier in circuit and for contact with the animal skin; an indifferent reservoir system supplied with an ion solution, positioned on the carrier in circuit for contact with the animal skin, and an anode in fluid communication with a battery electrolyte, the anode and battery electrolyte associated with the disposable part and arranged on the carrier so that upon conjugation of the carrier and support the battery electrolyte and the air cathode are in fluid communication to renew a power source, the anode and the anode contact engage to place the power source in circuit for supplying power to control.
Claim 4
Independent Claim 198 words
A device for electrically assisted transport of molecules through the skin of an animal comprising: a reusable part including a control in circuit for regulating the rate of electrically assisted transport and a support for attachment to the disposable part; an air cathode associated with the support and connected in circuit with the control; an anode contact associated with the support and connected in circuit but otherwise electrically isolated from the air cathode; a disposable part having a carrier shaped to conjugate with the support; an active reservoir system supplied with the molecules in solution, positioned on the carrier in circuit and for contact with the animal skin; an indifferent reservoir system supplied with an ion solution, positioned on the carrier in circuit for contact with the animal skin, and an anode in fluid communication with a battery electrolyte, the anode and battery electrolyte associated with the disposable part and arranged on the carrier so that upon conjugation of the carrier and support the battery electrolyte and the air cathode are in fluid communication to renew a power source, the anode and the anode contact engage to place the power source in circuit for supplying power to control.
Claim 5
Dependent Claim 43 words
The device of claim 2 wherein the support and the carrier are each generally planar and one of which has recesses to hold the anode, the active and indifferent reservoir systems and the battery electrolyte when the carrier and the support are conjugate.
Claim 6
Dependent Claim 17 words
The device of claim 3 wherein the indifferent reservoir system contains the ion solution in a matrix.
Claim 7
Dependent Claim 18 words
The device of claim 4 wherein the ion solution includes a buffered saline above about 0.1 molar concentration.
Claim 8
Dependent Claim 26 words
The device of claim 4 wherein the battery electrolyte includes a saline solution above about 0.1 molar concentration with a pH of about 9 or above.
Claim 9
Dependent Claim 16 words
The device of claim 2 wherein the air cathode includes activated carbon on a conductive layer.
Claim 10
Dependent Claim 24 words
The device of claim 7 wherein the battery electrolyte is in a sandwich between the activated carbon of the air cathode and the anode.
Claim 11
Dependent Claim 22 words
The device of claim 2 wherein the active reservoir system contains an aqueous solution of the molecules in solution in a matrix.
Claim 12
Dependent Claim 14 words
The device of claim 2 wherein the ion solution is contained in a matrix.
Claim 13
Dependent Claim 11 words
The device of claim 10 wherein the matrix is a gel.
Claim 14
Dependent Claim 12 words
The device of claim 10 wherein the matrix is a porous polymer.
Claim 15
Dependent Claim 15 words
The device of claim 2 wherein the molecules in solution is contained in a matrix.
Claim 16
Dependent Claim 11 words
The device of claim 13 wherein the matrix is a gel.
Claim 17
Dependent Claim 12 words
The device of claim 13 wherein the matrix is a porous polymer.
Claim 18
Dependent Claim 54 words
The device of claim 2 wherein the active reservoir system and indifferent reservoir system are spaced apart from one another in circuit and against the animal skin so the power source supplies energy through the control and an electric field is established through the animal skin between the active and indifferent electrically assisted systems.
Claim 19
Dependent Claim 27 words
The device of claim 2 wherein the carrier has a separatable power source section so that the consumable portion of the power source can be independently renewed.
Claim 20
Independent Claim 112 words
A method for renewing and replenishing a power source for a device for electrically assisted transport of molecules in solution including the following steps: providing means for electrically assisted transport having a reusable part and a disposable part; providing the reusable part with an air cathode and an anode contact on a support; providing the disposable part having an anode in fluid communication with a battery electrolyte on a carrier; renewing the power source by joining the support and the carrier, so that the battery electrolyte, the air cathode and the anode are in fluid communication, and electrically connecting the anode with the anode contact by joining the support and the carrier.
Claim 21
Independent Claim 112 words
A method for renewing and replenishing a power source for a device for electrically assisted transport of molecules in solution including the following steps: providing means for electrically assisted transport having a reusable part and a disposable part; providing the reusable part with an air cathode and an anode contact on a support; providing the disposable part having an anode in fluid communication with a battery electrolyte on a carrier; renewing the power source by joining the support and the carrier, so that the battery electrolyte, the air cathode and the anode are in fluid communication, and electrically connecting the anode with the anode contact by joining the support and the carrier.
Claim 22
Independent Claim 147 words
A method of providing a device for electrically assisted transport of molecules in solution having the steps of: placing in a disposable part of the device for electrically assisted transport a battery electrolyte in fluid communication with an anode, an ion solution in an indifferent reservoir system and an aqueous solution of molecules in solution in an active reservoir system; connecting an anode contact, an air cathode and a control in circuit in a reusable part of the electrically assisted device, and joining the disposable and reusable parts so that the air cathode, the anode and the battery electrolyte combine in a power source, the anode engages the anode contact to connect the power source to the control, and the aqueous solution in the active reservoir system and the ion solution in the indifferent reservoir system connect with the control to complete the electrically assisted transport device.
Claim 23
Independent Claim 147 words
A method of providing a device for electrically assisted transport of molecules in solution having the steps of: placing in a disposable part of the device for electrically assisted transport a battery electrolyte in fluid communication with an anode, an ion solution in an indifferent reservoir system and an aqueous solution of molecules in solution in an active reservoir system; connecting an anode contact, an air cathode and a control in circuit in a reusable part of the electrically assisted device, and joining the disposable and reusable parts so that the air cathode, the anode and the battery electrolyte combine in a power source, the anode engages the anode contact to connect the power source to the control, and the aqueous solution in the active reservoir system and the ion solution in the indifferent reservoir system connect with the control to complete the electrically assisted transport device.

References Cited (Backward Citations)

US4640689A Cited
US4693946A Cited
US4756980A Cited
US4842577A Cited
US4731049A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1994-08-05 1995-02-04 1995-08-06 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1998-08-05 1999-02-04 1999-08-06 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 2002-08-05 2003-02-04 2003-08-06 $7700.00 Window Closed / Lapsed

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